pI: 5.2432 |
Length (AA): 164 |
MW (Da): 18806 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 149 | 2vgl (S) | 1 | 142 | 39.00 | 0 | 1 | 1.48174 | -1.33 |
1 | 154 | 4p6z (S) | 1 | 147 | 32.00 | 0 | 1 | 1.44322 | -1.34 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128281)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G50860 | Clathrin adaptor complex small chain family protein |
Brugia malayi | Bm1_07400 | adaptin or adaptin-related protein protein 8 |
Candida albicans | CaO19.8023 | similar to S. cerevisiae APS3 (YJL024C) sigma3-like subunit of the clathrin-associated protein AP-3 complex |
Candida albicans | CaO19.393 | similar to S. cerevisiae APS3 (YJL024C) sigma3-like subunit of the clathrin-associated protein AP-3 complex |
Caenorhabditis elegans | CELE_Y48G8AL.14 | Protein APS-3 |
Dictyostelium discoideum | DDB_G0275405 | sigma adaptin |
Drosophila melanogaster | Dmel_CG3029 | orange |
Echinococcus granulosus | EgrG_001173750 | AP 3 complex subunit sigma 2 |
Echinococcus granulosus | EgrG_001113700 | AP 3 complex subunit sigma 2 |
Entamoeba histolytica | EHI_103550 | clathrin adaptor complex, small chain, putative |
Echinococcus multilocularis | EmuJ_001173750 | AP 3 complex subunit sigma 2 |
Echinococcus multilocularis | EmuJ_001113700 | AP 3 complex subunit sigma 2 |
Homo sapiens | 1176 | adaptor-related protein complex 3, sigma 1 subunit |
Homo sapiens | ENSG00000157823 | adaptor-related protein complex 3, sigma 2 subunit |
Leishmania braziliensis | LbrM.24.1320 | adaptor complex AP-3 small subunit, putative |
Leishmania donovani | LdBPK_241610.1 | adaptor complex AP-3 small subunit, putative |
Leishmania infantum | LinJ.24.1610 | adaptor complex AP-3 small subunit, putative |
Leishmania major | LmjF.24.1540 | adaptor complex AP-3 small subunit, putative |
Leishmania mexicana | LmxM.24.1540 | adaptor complex AP-3 small subunit, putative |
Loa Loa (eye worm) | LOAG_08409 | adaptin |
Mus musculus | ENSMUSG00000024480 | adaptor-related protein complex 3, sigma 1 subunit |
Mus musculus | ENSMUSG00000063801 | adaptor-related protein complex 3, sigma 2 subunit |
Neospora caninum | NCLIV_052120 | adaptor-related protein complex 3, sigma 2 subunit, putative |
Oryza sativa | 4332139 | Os03g0228400 |
Oryza sativa | 9270690 | Os01g0353600 |
Plasmodium berghei | PBANKA_1463400 | AP-3 complex subunit sigma, putative |
Plasmodium falciparum | PF3D7_1250500 | AP-3 complex subunit sigma, putative |
Plasmodium knowlesi | PKNH_1470500 | AP-3 complex subunit sigma, putative |
Plasmodium vivax | PVX_101420 | AP-3 complex subunit sigma, putative |
Saccharomyces cerevisiae | YJL024C | Aps3p |
Schistosoma japonicum | Sjp_0005740 | AP-3 complex subunit sigma-1, putative |
Schistosoma mansoni | Smp_034400 | adaptor-related protein complex |
Schmidtea mediterranea | mk4.001766.00 | |
Schmidtea mediterranea | mk4.004366.00 | |
Trypanosoma brucei gambiense | Tbg972.8.6860 | clathrin assembly sigma-adaptin protein 3, putative |
Trypanosoma brucei | Tb927.8.6680 | clathrin assembly sigma-adaptin protein 3, putative |
Trypanosoma congolense | TcIL3000_8_6560 | clathrin assembly sigma-adaptin protein 3, putative |
Trypanosoma cruzi | TcCLB.506399.10 | sigma-adaptin 3, putative |
Trypanosoma cruzi | TcCLB.507989.20 | sigma-adaptin 3, putative |
Trypanosoma cruzi | TcCLB.509243.50 | sigma-adaptin 3, putative |
Trypanosoma cruzi | TcCLB.510063.10 | sigma-adaptin 3, putative |
Toxoplasma gondii | TGME49_215130 | adaptor-related protein complex 3, sigma 2 subunit |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6680 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6680 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6680 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.6680 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y48G8AL.14 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y48G8AL.14 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y48G8AL.14 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1463400 | Plasmodium berghei | Slow | plasmo |
TGME49_215130 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | AP-2 complex subunit sigma | 142 aa | 39.2% | 148 aa | Compounds | References |
1 literature reference was collected for this gene.