Detailed view for PF3D7_1031200

Basic information

TDR Targets ID: 1380
Plasmodium falciparum, MORN repeat-containing protein 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.9436 | Length (AA): 364 | MW (Da): 41450 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02493   MORN repeat

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
139 293 3bga (A) 33 197 32.00 0.66 0.15 0.325124 1.7
139 293 3bga (A) 33 197 32.00 0.68 0.3 0.333024 1.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, merozoite, late schizont, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early ring, early schizont, early trophozoite, late ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, sporozoite, late trophozoite, Ring, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst. Otto TD Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128972)

Species Accession Gene Product
Babesia bovis BBOV_IV001320   phosphatidylinositol-4-phosphate 5-kinase, putative
Cryptosporidium hominis Chro.60298   phosphatidylinositol-4-phosphate 5-kinase, 11335-7537
Cryptosporidium parvum cgd6_2570   MORN domain repeat containing protein
Dictyostelium discoideum DDB_G0276561   hypothetical protein
Giardia lamblia GL50803_7261   Phosphatidylinositol-4-phosphate 5-kinase, putative
Homo sapiens ENSG00000169402   radial spoke head 10 homolog B2 (Chlamydomonas)
Homo sapiens ENSG00000155026   radial spoke head 10 homolog B (Chlamydomonas)
Leishmania braziliensis LbrM.30.3350   hypothetical protein, conserved
Leishmania donovani LdBPK_303360.1   MORN repeat-containing protein 1
Leishmania infantum LinJ.30.3360   hypothetical protein, conserved
Leishmania major LmjF.30.3310   hypothetical protein, conserved
Leishmania mexicana LmxM.29.3310   hypothetical protein, conserved
Mus musculus ENSMUSG00000075569   radial spoke head 10 homolog B (Chlamydomonas)
Neospora caninum NCLIV_054520   hypothetical protein
Plasmodium berghei PBANKA_0515200   MORN repeat-containing protein 1, putative
Plasmodium falciparum PF3D7_1031200   MORN repeat-containing protein 1
Plasmodium knowlesi PKNH_0615900   MORN repeat-containing protein 1, putative
Plasmodium vivax PVX_111165   MORN repeat-containing protein 1, putative
Plasmodium yoelii PY05981   MORN repeat, putative
Schistosoma japonicum Sjp_0301120   IPR003409,MORN motif,domain-containing
Schistosoma japonicum Sjp_0012290   Phosphatidylinositol-4-phosphate 5-kinase 6, putative
Schistosoma mansoni Smp_129740   hypothetical protein
Schmidtea mediterranea mk4.001178.02  
Trypanosoma brucei gambiense Tbg972.6.4490   CMRP,flagellar component
Trypanosoma brucei Tb927.6.4670   MORN repeat-containing protein 1
Trypanosoma congolense TcIL3000_6_4110   MORN repeat-containing protein 1
Trypanosoma cruzi TcCLB.511729.60   MORN repeat-containing protein 1
Toxoplasma gondii TGME49_310440   membrane occupation and recognition nexus protein MORN1
Theileria parva TP01_0158   hypothetical protein, conserved
Trichomonas vaginalis TVAG_100020   morn protein, putative

Essentiality

PF3D7_1031200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4670 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4670 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4670 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.4670 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0515200 Plasmodium berghei Dispensable plasmo
TGME49_310440 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1031200 (Plasmodium falciparum), MORN repeat-containing protein 1
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