pI: 11.7366 |
Length (AA): 137 |
MW (Da): 15684 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 135 | 4kzy (Y) | 4 | 128 | 53.00 | 0 | 1 | 1.51791 | 0.22 |
10 | 101 | 1xn9 (A) | 1 | 89 | 28.00 | 0 | 0.75 | 0.995433 | -0.06 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126896)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G04920 | 40S ribosomal protein S24-1 |
Arabidopsis thaliana | AT5G28060 | 40S ribosomal protein S24-2 |
Babesia bovis | BBOV_II003270 | 40S ribosomal protein S24 protein, putative |
Brugia malayi | Bm1_04620 | 40S ribosomal protein S24 |
Candida albicans | CaO19.5466 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS24A (YER074W) and RPS24B (YIL069C) small subunit protein S24 |
Candida albicans | CaO19.12921 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS24A (YER074W) and RPS24B (YIL069C) small subunit protein S24 |
Caenorhabditis elegans | CELE_T07A9.11 | Protein RPS-24 |
Cryptosporidium hominis | Chro.20023 | 40S ribosomal subunit protein S24 |
Cryptosporidium parvum | cgd2_170 | 40s ribosomal protein s24 |
Dictyostelium discoideum | DDB_G0275473 | 40S ribosomal protein S24 |
Drosophila melanogaster | Dmel_CG3751 | Ribosomal protein S24 |
Echinococcus granulosus | EgrG_000925000 | 40S ribosomal protein S24 |
Entamoeba histolytica | EHI_078300 | ribosomal protein S24, putative |
Entamoeba histolytica | EHI_148820 | ribosomal protein S24, putative |
Entamoeba histolytica | EHI_146560 | ribosomal protein S24, putative |
Echinococcus multilocularis | EmuJ_000925000 | 40S ribosomal protein S24 |
Giardia lamblia | GL50803_10367 | Ribosomal protein S24 |
Homo sapiens | ENSG00000138326 | ribosomal protein S24 |
Leishmania braziliensis | LbrM.35.3090 | 40S ribosomal protein S24e |
Leishmania donovani | LdBPK_363020.1 | 40S ribosomal protein S24e |
Leishmania infantum | LinJ.36.3020 | 40S ribosomal protein S24e |
Leishmania infantum | LinJ.36.3010 | 40S ribosomal protein S24e |
Leishmania major | LmjF.36.2870 | 40S ribosomal protein S24e |
Leishmania major | LmjF.36.2860 | 40S ribosomal protein S24e |
Leishmania mexicana | LmxM.36.2870 | 40S ribosomal protein S24e |
Leishmania mexicana | LmxM.36.2860 | 40S ribosomal protein S24e |
Loa Loa (eye worm) | LOAG_10577 | 40S ribosomal protein S24 |
Mus musculus | 225058 | predicted gene 4832 |
Mus musculus | ENSMUSG00000025290 | ribosomal protein S24 |
Mus musculus | 102642752 | 40S ribosomal protein S24-like |
Neospora caninum | NCLIV_052380 | hypothetical protein |
Oryza sativa | 4328797 | Os02g0229000 |
Oryza sativa | 4341282 | Os06g0555400 |
Oryza sativa | 4324671 | Os01g0723200 |
Plasmodium berghei | PBANKA_1234200 | 40S ribosomal protein S24, putative |
Plasmodium falciparum | PF3D7_0519400 | 40S ribosomal protein S24 |
Plasmodium knowlesi | PKNH_1013700 | 40S ribosomal protein S24, putative |
Plasmodium vivax | PVX_080275 | 40S ribosomal protein S24, putative |
Plasmodium yoelii | PY06213 | 40s ribosomal protein s24. [mouse-ear cress |
Saccharomyces cerevisiae | YER074W | ribosomal 40S subunit protein S24A |
Saccharomyces cerevisiae | YIL069C | ribosomal 40S subunit protein S24B |
Schistosoma japonicum | Sjp_0052260 | ko:K02974 small subunit ribosomal protein S24e, putative |
Schistosoma mansoni | Smp_091640 | 40S ribosomal protein S24 |
Schmidtea mediterranea | mk4.000391.01 | 40S ribosomal protein S24 |
Trypanosoma brucei gambiense | Tbg972.10.9010 | 40S ribosomal protein S24E, putative |
Trypanosoma brucei gambiense | Tbg972.10.9000 | 40S ribosomal protein S24E, putative |
Trypanosoma brucei | Tb927.10.7340 | 40S ribosomal protein S24E, putative |
Trypanosoma brucei | Tb927.10.7330 | 40S ribosomal protein S24E, putative |
Trypanosoma congolense | TcIL3000_10_6320 | 40S ribosomal protein S24E, putative |
Trypanosoma congolense | TcIL3000_10_6310 | 40S ribosomal protein S24E, putative |
Trypanosoma cruzi | TcCLB.507681.160 | 40S ribosomal protein S24E, putative |
Trypanosoma cruzi | TcCLB.507681.150 | 40S ribosomal protein S24E, putative |
Toxoplasma gondii | TGME49_215460 | ribosomal protein RPS24 |
Theileria parva | TP04_0266 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_272960 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_371240 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_272980 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_319220 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_272970 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_371250 | 40S ribosomal protein S24, putative |
Trichomonas vaginalis | TVAG_386300 | 40S ribosomal protein S24, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.7330 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7330 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7330 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.7330 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T07A9.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T07A9.11 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T07A9.11 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1234200 | Plasmodium berghei | Essential | plasmo |
TGME49_215460 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.