Detailed view for TGME49_215460

Basic information

TDR Targets ID: 262040
Toxoplasma gondii, ribosomal protein RPS24
Source Database / ID:  ToxoDB 

pI: 11.6693 | Length (AA): 267 | MW (Da): 30375 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01282   Ribosomal protein S24e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0000166   nucleotide binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 52 1r2u (A) 36 87 15.00 0.000000043 0.04 0.52 -0.26
9 110 1xn9 (A) 3 101 26.00 0 0.99 1.09 -0.11
32 172 1it9 (H) 95 218 31.00 0.74 0.24 0.47949 1.53
137 232 2v94 (A) 0 93 23.00 0 0.99 0.726451 -0.64
137 264 4kzy (Y) 3 128 48.00 0 1 1.0313 0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. Gregory Hehl AB Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile ME49 Oocyst. Fritz HM
Show/Hide expression data references
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_126896)

Species Accession Gene Product
Arabidopsis thaliana AT3G04920   40S ribosomal protein S24-1
Arabidopsis thaliana AT5G28060   40S ribosomal protein S24-2
Babesia bovis BBOV_II003270   40S ribosomal protein S24 protein, putative
Brugia malayi Bm1_04620   40S ribosomal protein S24
Candida albicans CaO19.5466   likely cytosolic ribosomal protein similar to S. cerevisiae RPS24A (YER074W) and RPS24B (YIL069C) small subunit protein S24
Candida albicans CaO19.12921   likely cytosolic ribosomal protein similar to S. cerevisiae RPS24A (YER074W) and RPS24B (YIL069C) small subunit protein S24
Caenorhabditis elegans CELE_T07A9.11   Protein RPS-24
Cryptosporidium hominis Chro.20023   40S ribosomal subunit protein S24
Cryptosporidium parvum cgd2_170   40s ribosomal protein s24
Dictyostelium discoideum DDB_G0275473   40S ribosomal protein S24
Drosophila melanogaster Dmel_CG3751   Ribosomal protein S24
Echinococcus granulosus EgrG_000925000   40S ribosomal protein S24
Entamoeba histolytica EHI_078300   ribosomal protein S24, putative
Entamoeba histolytica EHI_148820   ribosomal protein S24, putative
Entamoeba histolytica EHI_146560   ribosomal protein S24, putative
Echinococcus multilocularis EmuJ_000925000   40S ribosomal protein S24
Giardia lamblia GL50803_10367   Ribosomal protein S24
Homo sapiens ENSG00000138326   ribosomal protein S24
Leishmania braziliensis LbrM.35.3090   40S ribosomal protein S24e
Leishmania donovani LdBPK_363020.1   40S ribosomal protein S24e
Leishmania infantum LinJ.36.3020   40S ribosomal protein S24e
Leishmania infantum LinJ.36.3010   40S ribosomal protein S24e
Leishmania major LmjF.36.2870   40S ribosomal protein S24e
Leishmania major LmjF.36.2860   40S ribosomal protein S24e
Leishmania mexicana LmxM.36.2870   40S ribosomal protein S24e
Leishmania mexicana LmxM.36.2860   40S ribosomal protein S24e
Loa Loa (eye worm) LOAG_10577   40S ribosomal protein S24
Mus musculus 225058   predicted gene 4832
Mus musculus ENSMUSG00000025290   ribosomal protein S24
Mus musculus 102642752   40S ribosomal protein S24-like
Neospora caninum NCLIV_052380   hypothetical protein
Oryza sativa 4328797   Os02g0229000
Oryza sativa 4341282   Os06g0555400
Oryza sativa 4324671   Os01g0723200
Plasmodium berghei PBANKA_1234200   40S ribosomal protein S24, putative
Plasmodium falciparum PF3D7_0519400   40S ribosomal protein S24
Plasmodium knowlesi PKNH_1013700   40S ribosomal protein S24, putative
Plasmodium vivax PVX_080275   40S ribosomal protein S24, putative
Plasmodium yoelii PY06213   40s ribosomal protein s24. [mouse-ear cress
Saccharomyces cerevisiae YER074W   ribosomal 40S subunit protein S24A
Saccharomyces cerevisiae YIL069C   ribosomal 40S subunit protein S24B
Schistosoma japonicum Sjp_0052260   ko:K02974 small subunit ribosomal protein S24e, putative
Schistosoma mansoni Smp_091640   40S ribosomal protein S24
Schmidtea mediterranea mk4.000391.01   40S ribosomal protein S24
Trypanosoma brucei gambiense Tbg972.10.9010   40S ribosomal protein S24E, putative
Trypanosoma brucei gambiense Tbg972.10.9000   40S ribosomal protein S24E, putative
Trypanosoma brucei Tb927.10.7340   40S ribosomal protein S24E, putative
Trypanosoma brucei Tb927.10.7330   40S ribosomal protein S24E, putative
Trypanosoma congolense TcIL3000_10_6320   40S ribosomal protein S24E, putative
Trypanosoma congolense TcIL3000_10_6310   40S ribosomal protein S24E, putative
Trypanosoma cruzi TcCLB.507681.160   40S ribosomal protein S24E, putative
Trypanosoma cruzi TcCLB.507681.150   40S ribosomal protein S24E, putative
Toxoplasma gondii TGME49_215460   ribosomal protein RPS24
Theileria parva TP04_0266   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_272960   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_371240   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_272980   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_319220   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_272970   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_371250   40S ribosomal protein S24, putative
Trichomonas vaginalis TVAG_386300   40S ribosomal protein S24, putative

Essentiality

TGME49_215460 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7330 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.7330 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.7330 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.7330 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T07A9.11 Caenorhabditis elegans larval arrest wormbase
CELE_T07A9.11 Caenorhabditis elegans slow growth wormbase
CELE_T07A9.11 Caenorhabditis elegans sterile wormbase
PBANKA_1234200 Plasmodium berghei Essential plasmo
TGME49_215460 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TGME49_215460 (Toxoplasma gondii), ribosomal protein RPS24
Title for this comment
Comment