Detailed view for Tb927.6.1380

Basic information

TDR Targets ID: 16247
Trypanosoma brucei, cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.3238 | Length (AA): 204 | MW (Da): 21938 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_148842)

Species Accession Gene Product
Leishmania braziliensis LbrM.30.0030   cyclophilin 9, putative
Leishmania donovani LdBPK_300020.1   cyclophilin, putative
Leishmania infantum LinJ.30.0020   cyclophilin 9, putative
Leishmania major LmjF.30.0020   cyclophilin 9, putative
Leishmania mexicana LmxM.29.0020   cyclophilin, putative
Trypanosoma brucei gambiense Tbg972.6.1040   cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.6.1320   cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.6.1400   cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.6.1380   cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.6.1360   cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma congolense TcIL3000_0_54640   cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma cruzi TcCLB.505807.10   cyclophilin, putative
Trypanosoma cruzi TcCLB.509033.30   cyclophilin, putative

Essentiality

Tb927.6.1380 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.1320 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.1320 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.1320 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.6.1320 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 171 aa 34.7% 176 aa Compounds References
Rattus norvegicus Cyclophilin A 164 aa 35.1% 168 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

8 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb927.6.1380 (Trypanosoma brucei), cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
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