pI: 6.2972 |
Length (AA): 681 |
MW (Da): 76667 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
52 | 99 | 1nay (A) | 107 | 154 | 10.00 | 0.79 | 0 | 0.260985 | -1.1 |
321 | 647 | 4mew (A) | 164 | 481 | 31.00 | 0 | 1 | 0.868676 | -0.61 |
377 | 644 | 4i5j (A) | 179 | 441 | 36.00 | 0 | 1 | 0.861039 | -1.01 |
403 | 644 | 4mew (A) | 241 | 478 | 43.00 | 0 | 1 | 0.91076 | -0.73 |
543 | 680 | 2hps (A) | 7 | 138 | 12.00 | 0 | 0.04 | 0.259143 | -0.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127605)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G28900 | probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma |
Arabidopsis thaliana | AT1G03960 | calcium-binding EF-hand-containing protein |
Arabidopsis thaliana | AT5G28850 | serine/threonine protein phosphatase 2A regulatory subunit B''beta |
Arabidopsis thaliana | AT5G44090 | serine/threonine protein phosphatase 2A regulatory subunit B''alpha |
Arabidopsis thaliana | AT1G54450 | calcium-binding EF-hand-containing protein |
Brugia malayi | Bm1_36600 | EF hand family protein |
Brugia malayi | Bm1_11800 | protein phosphatase 2A |
Caenorhabditis elegans | CELE_C06G1.5 | Protein C06G1.5, isoform A |
Cryptosporidium hominis | Chro.70554 | CG4733-PA |
Cryptosporidium parvum | cgd7_4970 | protein phosphatase 2A regulatory subunit (contains a conserved version of EF hands) |
Dictyostelium discoideum | DDB_G0279813 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4733 | CG4733 gene product from transcript CG4733-RD |
Echinococcus granulosus | EgrG_000875600 | serine:threonine protein phosphatase 2A |
Echinococcus multilocularis | EmuJ_000875600 | serine:threonine protein phosphatase 2A |
Giardia lamblia | GL50803_17538 | Phosphoprotein phosphatase 2A regulatory subunit |
Giardia lamblia | GL50803_9894 | Protein phosphatase 2A regulatory subunit, putative |
Homo sapiens | ENSG00000073711 | protein phosphatase 2, regulatory subunit B'', alpha |
Homo sapiens | 102725016 | serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like |
Homo sapiens | 102724991 | serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like |
Homo sapiens | ENSG00000167393 | protein phosphatase 2, regulatory subunit B'', beta |
Leishmania braziliensis | LbrM.34.3120 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.17.0650 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_170730.1 | EF-hand domain pair, putative |
Leishmania donovani | LdBPK_353260.1 | EF-hand domain pair, putative |
Leishmania infantum | LinJ.35.3260 | hypothetical protein, conserved |
Leishmania infantum | LinJ.17.0730 | hypothetical protein, conserved |
Leishmania major | LmjF.35.3210 | hypothetical protein, conserved |
Leishmania major | LmjF.17.0750 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.17.0750 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.34.3210 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05562 | protein phosphatase 2A |
Loa Loa (eye worm) | LOAG_10207 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10206 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08349 | hypothetical protein |
Mus musculus | ENSMUSG00000043154 | protein phosphatase 2, regulatory subunit B'', alpha |
Mus musculus | ENSMUSG00000093803 | protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta |
Neospora caninum | NCLIV_038240 | hypothetical protein |
Oryza sativa | 4328580 | Os02g0191700 |
Oryza sativa | 4348893 | Os10g0476600 |
Plasmodium berghei | PBANKA_1132700 | phosphatase 2A regulatory subunit-related protein, putative |
Plasmodium falciparum | PF3D7_1356400 | phosphatase 2A regulatory subunit-related protein, putative |
Plasmodium knowlesi | PKNH_1115100 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_114800 | hypothetical protein, conserved |
Plasmodium yoelii | PY01608 | Arabidopsis thaliana At5g28850/F7P1_30 |
Schistosoma japonicum | Sjp_0312740 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta, putative |
Schistosoma japonicum | Sjp_0133710 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha, putative |
Schistosoma japonicum | Sjp_0089540 | ko:K01090 protein phosphatase [EC3.1.3.16], putative |
Schistosoma mansoni | Smp_089930 | phosphatase 2a regulatory subunit-related |
Schmidtea mediterranea | mk4.000908.01 | Phosphatase 2a regulatory subunit-related |
Schmidtea mediterranea | mk4.012041.00 | |
Schmidtea mediterranea | mk4.012041.04 | |
Schmidtea mediterranea | mk4.017609.00 | |
Trypanosoma brucei gambiense | Tbg972.7.7950 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.9.7530 | hypothetical protein, conserved |
Trypanosoma brucei | Tb11.v5.0895 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.6810 | EF-hand domain pair, putative |
Trypanosoma brucei | Tb927.9.12340 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000_9_5120 | EF-hand domain pair, putative |
Trypanosoma cruzi | TcCLB.510741.30 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510661.240 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510057.4 | EF-hand domain pair, putative |
Trypanosoma cruzi | TcCLB.503967.4 | EF-hand domain pair, putative |
Trypanosoma cruzi | TcCLB.508909.170 | EF-hand domain pair, putative |
Toxoplasma gondii | TGME49_200400 | hypothetical protein |
Trichomonas vaginalis | TVAG_070200 | serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.3350 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.3350 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.3350 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.3350 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.7.6810 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.6810 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.6810 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.6810 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1132700 | Plasmodium berghei | Essential | plasmo |
TGME49_200400 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.