pI: 7.2997 |
Length (AA): 925 |
MW (Da): 99929 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128028)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G26410 | tRNA modification 11 protein |
Babesia bovis | BBOV_IV002880 | RNA methylase, putative |
Brugia malayi | Bm1_15325 | hypothetical protein |
Candida albicans | CaO19.5987 | potential SAM-dependent RNA methylase similar to S. cerevisiae YOL124C |
Candida albicans | CaO19.13408 | potential SAM-dependent RNA methylase similar to S. cerevisiae YOL124C |
Caenorhabditis elegans | CELE_Y71F9AL.1 | Protein Y71F9AL.1 |
Cryptosporidium hominis | Chro.50400 | hypothetical protein |
Cryptosporidium parvum | cgd5_4420 | MJ0710-like (thump + methylase domains). RNA methylase |
Dictyostelium discoideum | DDB_G0283969 | tRNA guanosine-2'-O-methyltransferase 11 |
Drosophila melanogaster | Dmel_CG1074 | CG1074 gene product from transcript CG1074-RA |
Echinococcus granulosus | EgrG_000926200 | tRNA guanosine 2' O methyltransferase TRM11 |
Entamoeba histolytica | EHI_023130 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000926200 | tRNA guanosine 2' O methyltransferase TRM11 |
Giardia lamblia | GL50803_13525 | RNA methylase, putative |
Homo sapiens | ENSG00000066651 | tRNA methyltransferase 11 homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.05.1010 | methyltransferase-like protein |
Leishmania donovani | LdBPK_051010.1 | methyltransferase-like protein |
Leishmania infantum | LinJ.05.1010 | methyltransferase-like protein |
Leishmania major | LmjF.05.1010 | methyltransferase-like protein |
Leishmania mexicana | LmxM.05.1010 | methyltransferase-like protein |
Loa Loa (eye worm) | LOAG_07725 | hypothetical protein |
Mus musculus | ENSMUSG00000019792 | tRNA methyltransferase 11 |
Neospora caninum | NCLIV_068140 | Methyltransferase-like protein, related |
Oryza sativa | 4329664 | Os02g0556400 |
Plasmodium berghei | PBANKA_1356200 | tRNA guanosine-2'-O-methyltransferase, putative |
Plasmodium falciparum | PF3D7_1343200 | tRNA guanosine-2'-O-methyltransferase, putative |
Plasmodium knowlesi | PKNH_1258200 | tRNA guanosine-2'-O-methyltransferase, putative |
Plasmodium vivax | PVX_083055 | hypothetical protein, conserved |
Plasmodium yoelii | PY05490 | hypothetical protein |
Saccharomyces cerevisiae | YOL124C | Trm11p |
Schistosoma japonicum | Sjp_0020400 | ko:K00599 TRMT11, C6orf75; tRNA methyltransferase 11 homolog [EC:2.1.1.-], putative |
Schistosoma mansoni | Smp_077670 | hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.5.500 | methyltransferase, putative |
Trypanosoma brucei | Tb11.v5.0219 | methyltransferase, putative |
Trypanosoma brucei | Tb927.5.490 | methyltransferase, putative |
Trypanosoma congolense | TcIL3000_5_110 | methyltransferase, putative |
Trypanosoma cruzi | TcCLB.509885.60 | methyltransferase, putative |
Trypanosoma cruzi | TcCLB.508397.60 | methyltransferase, putative |
Toxoplasma gondii | TGME49_277860 | hypothetical protein |
Theileria parva | TP01_0635 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_299110 | S.cerevisiae chromosome XV reading frame orf yol124c, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.490 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.490 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.490 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.490 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1356200 | Plasmodium berghei | Slow | plasmo |
TGME49_277860 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.