pI: 7.583 |
Length (AA): 483 |
MW (Da): 52515 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
130 | 176 | 5f4z (A) | 314 | 350 | 49.00 | 0.29 | 0.25 | 0.362408 | -0.27 |
372 | 483 | 5e71 (A) | 142 | 240 | 27.00 | 0.0041 | 0.97 | 0.453284 | -0.11 |
389 | 474 | 5bxy (A) | 1 | 87 | 17.00 | 0.0093 | 0.16 | 0.368454 | -0.41 |
398 | 478 | 2as0 (A) | 204 | 296 | 17.00 | 0.014 | 0.19 | 0.227102 | -0.37 |
412 | 441 | 2zie (B) | 236 | 265 | 47.00 | 0.27 | 0.61 | 0.526212 | 0.6 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Ortholog group members (OG5_128028)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G26410 | tRNA modification 11 protein |
Babesia bovis | BBOV_IV002880 | RNA methylase, putative |
Brugia malayi | Bm1_15325 | hypothetical protein |
Candida albicans | CaO19.5987 | potential SAM-dependent RNA methylase similar to S. cerevisiae YOL124C |
Candida albicans | CaO19.13408 | potential SAM-dependent RNA methylase similar to S. cerevisiae YOL124C |
Caenorhabditis elegans | CELE_Y71F9AL.1 | Protein Y71F9AL.1 |
Cryptosporidium hominis | Chro.50400 | hypothetical protein |
Cryptosporidium parvum | cgd5_4420 | MJ0710-like (thump + methylase domains). RNA methylase |
Dictyostelium discoideum | DDB_G0283969 | tRNA guanosine-2'-O-methyltransferase 11 |
Drosophila melanogaster | Dmel_CG1074 | CG1074 gene product from transcript CG1074-RA |
Echinococcus granulosus | EgrG_000926200 | tRNA guanosine 2' O methyltransferase TRM11 |
Entamoeba histolytica | EHI_023130 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000926200 | tRNA guanosine 2' O methyltransferase TRM11 |
Giardia lamblia | GL50803_13525 | RNA methylase, putative |
Homo sapiens | ENSG00000066651 | tRNA methyltransferase 11 homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.05.1010 | methyltransferase-like protein |
Leishmania donovani | LdBPK_051010.1 | methyltransferase-like protein |
Leishmania infantum | LinJ.05.1010 | methyltransferase-like protein |
Leishmania major | LmjF.05.1010 | methyltransferase-like protein |
Leishmania mexicana | LmxM.05.1010 | methyltransferase-like protein |
Loa Loa (eye worm) | LOAG_07725 | hypothetical protein |
Mus musculus | ENSMUSG00000019792 | tRNA methyltransferase 11 |
Neospora caninum | NCLIV_068140 | Methyltransferase-like protein, related |
Oryza sativa | 4329664 | Os02g0556400 |
Plasmodium berghei | PBANKA_1356200 | tRNA guanosine-2'-O-methyltransferase, putative |
Plasmodium falciparum | PF3D7_1343200 | tRNA guanosine-2'-O-methyltransferase, putative |
Plasmodium knowlesi | PKNH_1258200 | tRNA guanosine-2'-O-methyltransferase, putative |
Plasmodium vivax | PVX_083055 | hypothetical protein, conserved |
Plasmodium yoelii | PY05490 | hypothetical protein |
Saccharomyces cerevisiae | YOL124C | Trm11p |
Schistosoma japonicum | Sjp_0020400 | ko:K00599 TRMT11, C6orf75; tRNA methyltransferase 11 homolog [EC:2.1.1.-], putative |
Schistosoma mansoni | Smp_077670 | hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.5.500 | methyltransferase, putative |
Trypanosoma brucei | Tb11.v5.0219 | methyltransferase, putative |
Trypanosoma brucei | Tb927.5.490 | methyltransferase, putative |
Trypanosoma congolense | TcIL3000_5_110 | methyltransferase, putative |
Trypanosoma cruzi | TcCLB.509885.60 | methyltransferase, putative |
Trypanosoma cruzi | TcCLB.508397.60 | methyltransferase, putative |
Toxoplasma gondii | TGME49_277860 | hypothetical protein |
Theileria parva | TP01_0635 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_299110 | S.cerevisiae chromosome XV reading frame orf yol124c, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.490 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.490 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.490 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.490 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1356200 | Plasmodium berghei | Slow | plasmo |
TGME49_277860 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.