pI: 7.4379 |
Length (AA): 803 |
MW (Da): 90812 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127585)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G03190 | DNA repair helicase UVH6 |
Babesia bovis | BBOV_IV001300 | DNA excision repair helicase |
Brugia malayi | Bm1_45675 | probable DNA helicase ERCC2/XPD - southern platyfish, putative |
Candida albicans | CaO19_7119 | hypothetical protein |
Candida albicans | CaO19.7119 | DNA helicase component of transcription factor TFIIH, DNA excision repair complexes |
Caenorhabditis elegans | CELE_Y50D7A.2 | Protein Y50D7A.2 |
Cryptosporidium hominis | Chro.70101 | DNA repair protein-related |
Cryptosporidium parvum | cgd7_820 | RAD3DEXDc+HELICc protein |
Dictyostelium discoideum | DDB_G0267414 | transcription factor IIH component |
Drosophila melanogaster | Dmel_CG9433 | Xeroderma pigmentosum D ortholog (H. sapiens) |
Echinococcus granulosus | EgrG_000896400 | DNA repair helicase rad3:xp d |
Entamoeba histolytica | EHI_132410 | DNA repair helicase, putative |
Entamoeba histolytica | EHI_197850 | DNA repair helicase, putative |
Echinococcus multilocularis | EmuJ_000896400 | DNA repair helicase rad3:xp d |
Giardia lamblia | GL50803_4328 | TFIIH basal transcription factor complex helicase subunit |
Homo sapiens | ENSG00000104884 | excision repair cross-complementation group 2 |
Leishmania braziliensis | LbrM.24.2360 | TFIIH basal transcription factor complex helicase subunit, putative,RAD3/XPD protein, putative,DNA excision repair protein, puta |
Leishmania donovani | LdBPK_242370.1 | TFIIH basal transcription factor complex helicase subunit, putative |
Leishmania infantum | LinJ.24.2370 | TFIIH basal transcription factor complex helicase subunit, putative,RAD3/XPD protein, putative,DNA excision repair protein, puta |
Leishmania major | LmjF.24.2280 | TFIIH basal transcription factor complex helicase subunit, putative,RAD3/XPD protein, putative,DNA excision repair protein, puta |
Leishmania mexicana | LmxM.24.2280 | TFIIH basal transcription factor complex helicase subunit, putative,RAD3/XPD protein, putative,DNA excision repair protein, puta |
Loa Loa (eye worm) | LOAG_13428 | TFIIH basal transcription factor complex helicase subunit |
Loa Loa (eye worm) | LOAG_13654 | TFIIH basal transcription factor complex helicase subunit |
Mus musculus | ENSMUSG00000030400 | excision repair cross-complementing rodent repair deficiency, complementation group 2 |
Neospora caninum | NCLIV_059440 | hypothetical protein |
Oryza sativa | 4337788 | Os05g0144800 |
Plasmodium berghei | PBANKA_0834900 | TFIIH basal transcription factor complex helicase XPD subunit, putative |
Plasmodium falciparum | PF3D7_0934100 | TFIIH basal transcription factor complex helicase XPD subunit |
Plasmodium knowlesi | PKNH_0732800 | TFIIH basal transcription factor complex helicase XPD subunit, putative |
Plasmodium vivax | PVX_087010 | TFIIH basal transcription factor complex helicase XPD subunit, putative |
Plasmodium yoelii | PY06097 | hypothetical protein |
Plasmodium yoelii | PY00738 | RAD3-like DNA helicase-related |
Saccharomyces cerevisiae | YER171W | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 |
Schistosoma japonicum | Sjp_0002530 | ko:K01529 excision repair cross-complementing rodent repair deficiency, complementation group 2 [EC:3.6.1.-], putative |
Schistosoma mansoni | Smp_095370 | DNA repair helicase rad3/xp-d |
Schmidtea mediterranea | mk4.010255.00 | TFIIH basal transcription factor complex helicase XPD subunit |
Schmidtea mediterranea | mk4.009546.00 | |
Schmidtea mediterranea | mk4.002491.02 | TFIIH basal transcription factor complex helicase XPD subunit |
Schmidtea mediterranea | mk4.006459.01 | TFIIH basal transcription factor complex helicase XPD subunit |
Trypanosoma brucei gambiense | Tbg972.8.5980 | TFIIH basal transcription factor complex helicase subunit, putative |
Trypanosoma brucei | Tb927.8.5980 | TFIIH basal transcription factor complex helicase subunit, putative |
Trypanosoma congolense | TcIL3000_8_5750 | TFIIH basal transcription factor complex helicase subunit, putative |
Trypanosoma cruzi | TcCLB.511075.30 | TFIIH basal transcription factor complex helicase subunit, putative |
Trypanosoma cruzi | TcCLB.511897.10 | TFIIH basal transcription factor complex helicase subunit, putative |
Toxoplasma gondii | TGME49_216870 | DNA excision repair helicase |
Theileria parva | TP01_0155 | DNA repair protein rad3, putative |
Trichomonas vaginalis | TVAG_023300 | DNA repair helicase rad3/xp-D, putative |
Trichomonas vaginalis | TVAG_442190 | DNA repair helicase rad3/xp-D, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5980 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5980 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5980 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.5980 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y50D7A.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y50D7A.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y50D7A.2 | Caenorhabditis elegans | slow growth | wormbase |
YER171W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0834900 | Plasmodium berghei | Essential | plasmo |
TGME49_216870 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
217 literature references were collected for this gene.