Detailed view for Tb927.11.10730

Basic information

TDR Targets ID: 19119
Trypanosoma brucei, SWI/SNF-related helicase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0549 | Length (AA): 1211 | MW (Da): 139633 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00176   SNF2 family N-terminal domain
PF00271   Helicase conserved C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0007126   meiosis  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  
GO:0004386   helicase activity  
GO:0003677   DNA binding  
GO:0003676   nucleic acid binding  
GO:0006338   chromatin remodeling  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127568)

Species Accession Gene Product
Arabidopsis thaliana AT3G12810   photoperiod-independent early flowering 1 protein
Babesia bovis BBOV_IV011770   snf2-related chromatin remodeling factor SRCAP
Brugia malayi Bm1_20790   SNF2 family N-terminal domain containing protein
Candida albicans CaO19.1871   putative RNA helicase
Candida albicans CaO19.9427   putative RNA helicase
Caenorhabditis elegans CELE_Y111B2A.22   Protein SSL-1, isoform C
Cryptosporidium hominis Chro.80359   hypothetical protein
Cryptosporidium parvum cgd8_3080   Swr1p like SWI/SNF2 family ATpase with a HSA domain at the N-terminus probably involved in chromatin remodelling
Dictyostelium discoideum DDB_G0267638   CHR group protein
Drosophila melanogaster Dmel_CG9696   domino
Echinococcus granulosus EgrG_000211600   helicase
Echinococcus multilocularis EmuJ_000211600   helicase
Homo sapiens ENSG00000183495   E1A binding protein p400
Homo sapiens ENSG00000080603   Snf2-related CREBBP activator protein
Leishmania braziliensis LbrM.35.5440   helicase, putative
Leishmania donovani LdBPK_365420.1   SWI/SNF-related helicase, putative
Leishmania infantum LinJ.36.5420   helicase, putative
Leishmania major LmjF.36.5190   helicase, putative
Leishmania mexicana LmxM.36.5190   helicase, putative
Loa Loa (eye worm) LOAG_00640   SNF2 family domain-containing protein
Mus musculus ENSMUSG00000029505   E1A binding protein p400
Mus musculus ENSMUSG00000053877   Snf2-related CREBBP activator protein
Neospora caninum NCLIV_019390   SNF2 family N-terminal domain-containing protein, putative
Onchocerca volvulus OVOC7803  
Plasmodium berghei PBANKA_0710800   Snf2-related CBP activator, putative
Plasmodium falciparum PF3D7_0820000   Snf2-related CBP activator, putative
Plasmodium knowlesi PKNH_1313800   Snf2-related CBP activator, putative
Plasmodium vivax PVX_089365   helicase, putative
Plasmodium yoelii PY01180   DOMINO B-related
Saccharomyces cerevisiae YDR334W   Swr1p
Schistosoma japonicum Sjp_0034870   Helicase SRCAP, putative
Schistosoma japonicum Sjp_0100800   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0034860   expressed protein
Schistosoma japonicum Sjp_0130440   Helicase ssl-1, putative
Schistosoma mansoni Smp_128890.2   helicase
Schistosoma mansoni Smp_128890.1   helicase
Schmidtea mediterranea mk4.001748.01   Putative helicase
Schmidtea mediterranea mk4.000094.15   Helicase domino
Schmidtea mediterranea mk4.000094.14  
Trypanosoma brucei gambiense Tbg972.11.12020   SNF2 DNA repair protein, putative,ATP-dependent helicase, putative,SNF2 family helicase, putative
Trypanosoma brucei Tb927.11.10730   SWI/SNF-related helicase, putative
Trypanosoma congolense TcIL3000.11.11390   SWI/SNF-related helicase, putative
Trypanosoma cruzi TcCLB.506155.70   SWI/SNF-related helicase, putative
Toxoplasma gondii TGME49_280800   SWI2/SNF2 SRCAP/Ino80
Theileria parva TP01_1132   ATP-dependent helicase, putative

Essentiality

Tb927.11.10730 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.2500 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.2500 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.2500 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.2500 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y111B2A.22 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y111B2A.22 Caenorhabditis elegans larval arrest wormbase
CELE_Y111B2A.22 Caenorhabditis elegans slow growth wormbase
PBANKA_0710800 Plasmodium berghei Essential plasmo
TGME49_280800 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.10730 (Trypanosoma brucei), SWI/SNF-related helicase, putative
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