Detailed view for PF3D7_1147800

Basic information

TDR Targets ID: 1951
Plasmodium falciparum, membrane associated erythrocyte binding-like protein
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.3008 | Length (AA): 2055 | MW (Da): 243213 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02430   Apical membrane antigen 1
PF11556   Erythrocyte binding antigen 175

Gene Ontology

Mouse over links to read term descriptions.
GO:0020007   apical complex  
GO:0008150   biological_process  
GO:0016020   membrane  
GO:0005488   binding  
GO:0009405   pathogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 21 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
796 998 1z40 (A) 203 432 26.00 0 0.92 0.06 1.03
1103 1385 1c1g (A) 2 281 16.00 0.00000027 0.04 0.27 -0.13
221 441 4uv6 (A) 144 397 28.00 0.0061 1 0.151043 1.08
505 608 1yn3 (A) 157 254 15.00 0.004 0.24 0.203808 -0.71
796 998 3zwz (A) 203 432 28.00 0.0017 1 0.271283 0.69
796 998 4r1a (A) 203 432 33.00 0.014 0.93 0.176283 0.77
898 1262 1f5n (A) 194 583 15.00 0.89 0.02 0.177116 0.49
1020 1238 4gnk (E) 936 1180 17.00 0.88 0.12 0.327069 -1.02
1064 1314 4hse (A) 246 528 29.00 0.22 0.04 0.150641 0.57
1103 1242 4wik (A) 448 594 24.00 0.54 0.02 0.289627 -0.73
1405 1695 3hjl (A) 5 323 27.00 0.037 1 0.321106 0.22
1441 1512 4o9b (A) 263 334 29.00 0.88 0.14 0.586536 -2.76
1524 1754 4tql (A) 10 238 37.00 0 1 0.570909 -1.07
1595 1781 4uos (A) 1 183 32.00 0.0000027 0.98 0.685498 -2.35
1638 1695 1lq7 (A) 2 66 55.00 0.047 0.77 0.671724 -1.65
1654 1791 3hhm (B) 430 575 24.00 0.44 0.52 0.424653 -1.44
1667 1787 2dq3 (A) 8 137 32.00 0.97 1 0.153381 -0.23
1899 1981 2rji (A) 1 84 48.00 0.000000000022 1 0.805889 -2.24
509 608 1yn3 (A) 161 254 16.00 0.16 0.29 0.232329 -0.84
876 1095 4tql (A) 9 231 10.00 0.046 0.02 0.239765 -0.79
1020 1238 4gnk (E) 936 1180 17.00 0.8 0.1 0.31527 -0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile sporozoite, Sporozoite, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile early trophozoite, Ring, Female Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, gametocyte, late trophozoite, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_126854)

Species Accession Gene Product
Arabidopsis thaliana AT4G36520   chaperone DnaJ-domain containing protein
Babesia bovis BBOV_I002740   200 kDa antigen p200
Brugia malayi Bm1_05690   Low-density lipoprotein receptor domain class A containing protein
Brugia malayi Bm1_14520   Immunoglobulin I-set domain containing protein
Brugia malayi Bm1_32990   Apical junction molecule protein 1
Brugia malayi Bm1_17345   Low-density lipoprotein receptor domain class A containing protein
Candida albicans CaO19.14055   lysine/glutamic acid-rich protein
Candida albicans CaO19.6763   lysine/glutamic acid-rich protein
Caenorhabditis elegans CELE_H39E23.3   Protein H39E23.3
Caenorhabditis elegans CELE_F49E2.5   Protein F49E2.5, isoform E
Caenorhabditis elegans CELE_C25A11.4   Protein AJM-1, isoform E
Cryptosporidium parvum cgd4_770   Low complexity protein with large Glu repeat
Dictyostelium discoideum DDB_G0270864   hypothetical protein
Dictyostelium discoideum DDB_G0285911   LIM-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG31551   CG31551 gene product from transcript CG31551-RA
Drosophila melanogaster Dmel_CG2839   CG2839 gene product from transcript CG2839-RA
Entamoeba histolytica EHI_059670   Rab family GTPase
Entamoeba histolytica EHI_050660   hypothetical protein, conserved
Entamoeba histolytica EHI_124620   hypothetical protein
Giardia lamblia GL50803_24122   Spindle pole protein, putative
Homo sapiens ENSG00000159450   trichohyalin
Homo sapiens ENSG00000100285   neurofilament, heavy polypeptide
Leishmania braziliensis LbrM.27.0260   kinetoplast-associated protein-like protein
Leishmania braziliensis LbrM.28.2410   glycoprotein 96-92, putative
Leishmania braziliensis LbrM.27.0250   kinetoplast-associated protein-like protein
Leishmania donovani LdBPK_282370.1   glycoprotein 96-92, putative
Leishmania infantum LinJ.28.2370   glycoprotein 96-92, putative
Leishmania infantum LinJ.27.0250   kinetoplast-associated protein-like protein
Leishmania major LmjF.27.0240   kinetoplast-associated protein-like protein
Loa Loa (eye worm) LOAG_06076   hypothetical protein
Loa Loa (eye worm) LOAG_01250   immunoglobulin I-set domain-containing protein
Loa Loa (eye worm) LOAG_15228   hypothetical protein
Loa Loa (eye worm) LOAG_06077   hypothetical protein
Loa Loa (eye worm) LOAG_10697   hypothetical protein
Loa Loa (eye worm) LOAG_05014   hypothetical protein
Loa Loa (eye worm) LOAG_10695   hypothetical protein
Mus musculus ENSMUSG00000052415   trichohyalin
Mus musculus ENSMUSG00000020396   neurofilament, heavy polypeptide
Neospora caninum NCLIV_015050   Proteophosphoglycan ppg4, related
Neospora caninum NCLIV_007540   hypothetical protein, conserved
Neospora caninum NCLIV_057110   IQ calmodulin-binding motif domain-containing protein, putative
Oryza sativa 4339717   Os05g0579900
Oryza sativa 4326602   Os01g0634300
Plasmodium berghei PBANKA_0901300   membrane associated erythrocyte binding-like protein
Plasmodium falciparum PF3D7_1147800   membrane associated erythrocyte binding-like protein
Plasmodium falciparum PF3D7_0504700   centrosomal protein CEP120, putative
Plasmodium knowlesi PKNH_0945700   membrane associated erythrocyte binding-like protein, putative
Plasmodium vivax PVX_097685   merozoite surface protein 3
Plasmodium vivax PVX_097690   merozoite surface protein 3
Plasmodium vivax PVX_097710   merozoite surface protein 3
Plasmodium vivax PVX_092975   merozoite adhesive erythrocytic binding protein
Plasmodium vivax PVX_097700   merozoite surface protein 3
Plasmodium vivax PVX_002510   Nucleosomal binding protein 1, putative
Plasmodium yoelii PY05977   erythrocyte binding protein
Schmidtea mediterranea mk4.000282.00  
Trypanosoma brucei gambiense Tbg972.7.8700   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.8.7560   kinetoplast-associated protein, putative
Trypanosoma brucei gambiense Tbg972.4.5305   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.7260   kinetoplast-associated protein, putative
Trypanosoma brucei Tb927.4.5120   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.7400   Basal body protein
Trypanosoma congolense TcIL3000_7_6020   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_8_7490   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_8_7380   kinetoplast-associated protein, putative
Trypanosoma cruzi TcCLB.510593.49   kinetoplast DNA-associated protein, putative
Trypanosoma cruzi TcCLB.510609.60   Basal body protein
Trypanosoma cruzi TcCLB.507969.10   vesicular transport-associated repeat protein, putative
Trypanosoma cruzi TcCLB.506303.80   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506811.160   R27-2 protein, putative
Trypanosoma cruzi TcCLB.507895.124   hypothetical protein, conserved
Toxoplasma gondii TGME49_309160   IgA-specific metalloendopeptidase
Toxoplasma gondii TGME49_313900   non-specific serine/threonine protein kinase
Treponema pallidum TP0769   outer membrane protein (tmpB)
Theileria parva TP01_0576   hypothetical protein, conserved
Trichomonas vaginalis TVAG_413070   trichohyalin, putative
Trichomonas vaginalis TVAG_295230   hypothetical protein
Trichomonas vaginalis TVAG_168130   axoneme-associated protein mst101, putative
Trichomonas vaginalis TVAG_459620   conserved hypothetical protein
Trichomonas vaginalis TVAG_141490   Moesin, putative
Trichomonas vaginalis TVAG_399600   conserved hypothetical protein
Trichomonas vaginalis TVAG_028600   conserved hypothetical protein
Trichomonas vaginalis TVAG_354150   trichohyalin, putative
Trichomonas vaginalis TVAG_221970   trichohyalin, putative
Trichomonas vaginalis TVAG_368240   axoneme-associated protein mst101, putative
Trichomonas vaginalis TVAG_144410   trichohyalin, putative
Trichomonas vaginalis TVAG_210560   trichohyalin, putative
Trichomonas vaginalis TVAG_298320   trichohyalin, putative
Trichomonas vaginalis TVAG_398490   trichohyalin, putative
Trichomonas vaginalis TVAG_295240   hypothetical protein
Trichomonas vaginalis TVAG_005450   conserved hypothetical protein

Essentiality

PF3D7_1147800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.5120 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.5120 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.5120 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.5120 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7260 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7260 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.7260 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.7260 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.7400 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.7400 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.7400 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.7400 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C25A11.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C25A11.4 Caenorhabditis elegans slow growth wormbase
CELE_F49E2.5 Caenorhabditis elegans larval lethal wormbase
TGME49_313900 Toxoplasma gondii Essentiality uncertain sidik
TGME49_309160 Toxoplasma gondii Essentiality uncertain sidik
TGME49_313900 Toxoplasma gondii Probably non-essential sidik
TGME49_309160 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1147800 (Plasmodium falciparum), membrane associated erythrocyte binding-like protein
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