pI: 6.4854 |
Length (AA): 515 |
MW (Da): 54701 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126728)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G26570 | 1 |
Babesia bovis | BBOV_II005570 | phosphate transporter, putative |
Brugia malayi | Bm1_35205 | Phosphate transporter family protein |
Candida albicans | CaO19.4599 | probable Na+/Pi symporter |
Candida albicans | CaO19.12068 | probable Na+/Pi symporter |
Caenorhabditis elegans | CELE_F09G2.3 | Protein PITR-5 |
Caenorhabditis elegans | CELE_C48A7.2 | Protein PITR-1 |
Caenorhabditis elegans | CELE_B0222.3 | Protein PITR-3 |
Caenorhabditis elegans | CELE_B0222.2 | Protein PITR-2 |
Chlamydia trachomatis | CT_692 | phosphate permease |
Drosophila melanogaster | Dmel_CG42575 | CG42575 gene product from transcript CG42575-RA |
Escherichia coli | b3493 | phosphate transporter, low-affinity |
Escherichia coli | b2987 | phosphate transporter |
Echinococcus granulosus | EgrG_000971100 | sodium dependent phosphate transporter 1 |
Echinococcus granulosus | EgrG_000971400 | sodium dependent phosphate transporter 2 |
Echinococcus multilocularis | EmuJ_000971400 | sodium dependent phosphate transporter 2 |
Echinococcus multilocularis | EmuJ_000971100 | sodium dependent phosphate transporter 1 |
Homo sapiens | ENSG00000168575 | solute carrier family 20 (phosphate transporter), member 2 |
Homo sapiens | ENSG00000144136 | solute carrier family 20 (phosphate transporter), member 1 |
Leishmania braziliensis | LbrM.28.3250 | phosphate-repressible phosphate permease |
Leishmania braziliensis | LbrM.10.0030 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania braziliensis | LbrM.10.1450 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania braziliensis | LbrM.20.4120 | phosphate-repressible phosphate permease |
Leishmania donovani | LdBPK_200040.1 | phosphate-repressible phosphate permease |
Leishmania donovani | LdBPK_030480.1 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania donovani | LdBPK_101440.1 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania infantum | LinJ.20.0040 | phosphate-repressible phosphate permease |
Leishmania infantum | LinJ.10.1440 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania infantum | LinJ.03.0480 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania infantum | LinJ.10.0010 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania major | LmjF.03.0500 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania major | LmjF.10.1300 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania major | LmjF.10.0030 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania mexicana | LmxM.03.0500 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania mexicana | LmxM.20.0031 | phosphate-repressible phosphate permease |
Leishmania mexicana | LmxM.10.1300 | phosphate-Repressible Phosphate Permease-like protein |
Leishmania mexicana | LmxM.10.0030 | phosphate-Repressible Phosphate Permease-like protein |
Loa Loa (eye worm) | LOAG_11239 | phosphate transporter |
Loa Loa (eye worm) | LOAG_08110 | solute carrier family 20 |
Loa Loa (eye worm) | LOAG_06338 | phosphate transporter |
Loa Loa (eye worm) | LOAG_11120 | phosphate permease |
Loa Loa (eye worm) | LOAG_11240 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11763 | hypothetical protein |
Mycobacterium leprae | ML2260c | PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA |
Mus musculus | ENSMUSG00000027397 | solute carrier family 20, member 1 |
Mus musculus | ENSMUSG00000037656 | solute carrier family 20, member 2 |
Mycobacterium tuberculosis | Rv0545c | Probable low-affinity inorganic phosphate transporter integral membrane protein PitA |
Mycobacterium tuberculosis | Rv2281 | Putative phosphate-transport permease PitB |
Mycobacterium ulcerans | MUL_2694 | phosphate-transport permease PitB |
Neospora caninum | NCLIV_016480 | hypothetical protein |
Oryza sativa | 4329844 | Os02g0593500 |
Onchocerca volvulus | OVOC7210 |
|
Onchocerca volvulus | OVOC7211 |
|
Plasmodium berghei | PBANKA_1354300 | sodium-dependent phosphate transporter, putative |
Plasmodium falciparum | PF3D7_1340900 | sodium-dependent phosphate transporter |
Plasmodium knowlesi | PKNH_1260500 | sodium-dependent phosphate transporter, putative |
Plasmodium vivax | PVX_082960 | sodium-dependent phosphate transporter, putative |
Plasmodium yoelii | PY01393 | solute carrier family 20, member 1-related |
Saccharomyces cerevisiae | YBR296C | Pho89p |
Schistosoma mansoni | Smp_094660 | phosphate transporter |
Schmidtea mediterranea | mk4.047682.01 | |
Schmidtea mediterranea | mk4.043315.01 | |
Schmidtea mediterranea | mk4.008985.00 | |
Trypanosoma brucei gambiense | Tbg972.1.50 | phosphate-repressible phosphate permease, putative |
Trypanosoma brucei gambiense | Tbg972.1.70 | phosphate-repressible phosphate permease, putative |
Trypanosoma brucei | Tb927.1.600 | phosphate-repressible phosphate permease, putative |
Trypanosoma brucei | Tb927.1.580 | phosphate-repressible phosphate permease, putative |
Trypanosoma congolense | TcIL3000_0_52300 | phosphate-repressible phosphate permease, putative |
Trypanosoma congolense | TcIL3000_1_150 | phosphate-repressible phosphate permease, putative |
Trypanosoma cruzi | TcCLB.505999.10 | phosphate-repressible phosphate permease, putative |
Trypanosoma cruzi | TcCLB.511417.90 | phosphate-repressible phosphate permease, putative |
Trypanosoma cruzi | TcCLB.505999.20 | phosphate-repressible phosphate permease, putative |
Trypanosoma cruzi | TcCLB.511417.80 | phosphate-repressible phosphate permease, putative |
Toxoplasma gondii | TGME49_240210 | phosphate transporter family protein, putative |
Theileria parva | TP02_0500 | phosphate transporter, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.600 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.600 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.600 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.1.600 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.1.580 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.580 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.580 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.580 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2987 | Escherichia coli | non-essential | goodall |
b3493 | Escherichia coli | non-essential | goodall |
CELE_C48A7.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_240210 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
1 literature reference was collected for this gene.