pI: 5.5598 |
Length (AA): 725 |
MW (Da): 86166 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 112 | 2fxo (A) | 846 | 958 | 14.00 | 0.42 | 0.01 | 0.374203 | -1.28 |
191 | 286 | 1ux6 (A) | 828 | 917 | 40.00 | 0.3 | 0.03 | 0.142214 | 0.37 |
665 | 723 | 2ct2 (A) | 14 | 74 | 20.00 | 0.21 | 0.82 | 0.429479 | -1.34 |
7 | 196 | 4uos (A) | 1 | 183 | 20.00 | 0.0013 | 0.17 | 0.557589 | -1.34 |
9 | 106 | 3na7 (A) | 26 | 130 | 37.00 | 0.29 | 0.02 | 0.321705 | -0.96 |
10 | 326 | 4h5y (A) | 160 | 454 | 26.00 | 0.32 | 0.37 | 0.42636 | 0.59 |
626 | 693 | 4v3l (C) | 399 | 462 | 19.00 | 0.79 | 0.71 | 0.336901 | -0.75 |
637 | 694 | 2ct2 (A) | 15 | 74 | 21.00 | 0.77 | 0.75 | 0.396933 | -0.95 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | gametocyte, sporozoite, early schizont, late schizont, Oocyst, Sporozoite, Female Gametocyte, Male Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | merozoite, early trophozoite, late trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, late ring, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs. | Otto TD |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128881)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G55070 | LisH/CRA/RING-U-box domain-containing protein |
Babesia bovis | BBOV_III003430 | hypothetical protein |
Brugia malayi | Bm1_02660 | erythroblast macrophage protein EMP |
Candida albicans | CaO19.7365 | weak similarity to FYV10 |
Caenorhabditis elegans | CELE_W09G3.2 | Protein MAEA-1 |
Dictyostelium discoideum | DDB_G0284463 | CT11-RanBPM domain-containing protein |
Drosophila melanogaster | Dmel_CG31357 | CG31357 gene product from transcript CG31357-RA |
Echinococcus granulosus | EgrG_000079900 | erythroblast macrophage protein EMP |
Echinococcus multilocularis | EmuJ_000079900 | erythroblast macrophage protein EMP |
Homo sapiens | ENSG00000090316 | macrophage erythroblast attacher |
Loa Loa (eye worm) | LOAG_07116 | erythroblast macrophage protein EMP |
Mus musculus | ENSMUSG00000079562 | macrophage erythroblast attacher |
Neospora caninum | NCLIV_039880 | hypothetical protein |
Oryza sativa | 4337882 | Os05g0160100 |
Plasmodium berghei | PBANKA_1345500 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1330500 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_1269900 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_082465 | hypothetical protein, conserved |
Plasmodium yoelii | PY06135 | similar to macrophage erythroblast attacher, putative |
Saccharomyces cerevisiae | YIL097W | glucose-induced degradation complex subunit FYV10 |
Schistosoma japonicum | Sjp_0058650 | Macrophage erythroblast attacher, putative |
Schistosoma mansoni | Smp_008470.2 | erythroblast macrophage protein emp |
Schistosoma mansoni | Smp_008470.1 | erythroblast macrophage protein emp |
Toxoplasma gondii | TGME49_265390 | hypothetical protein |
Theileria parva | TP03_0343 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_265390 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.