Detailed view for Bm1_33785

Basic information

TDR Targets ID: 236063
Brugia malayi, Neuronal calcium sensor family protein 1
Source Database / ID:  GenBank

pI: 6.8781 | Length (AA): 191 | MW (Da): 22045 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13405   EF-hand domain
PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 189 1fpw (A) 1 189 60.00 0 1 1.78593 -1.09
5 184 5g08 (A) 5 183 74.00 0 1 1.98281 -2.13
6 189 4guk (A) 6 189 74.00 0 1 1.95275 -1.72
150 181 1k9u (A) 41 72 22.00 0.37 0.03 0.390239 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127392)

Species Accession Gene Product
Arabidopsis thaliana AT5G24270   calcineurin B-like protein 4
Brugia malayi Bm1_33785   Neuronal calcium sensor family protein 1
Candida albicans CaO19.4726   putative calcium binding protein
Candida albicans CaO19.12189   putative calcium binding protein
Caenorhabditis elegans CELE_C44C1.3   Protein NCS-1
Dictyostelium discoideum DDB_G0274781   NCS-1/frequenin-related protein
Dictyostelium discoideum DDB_G0275931   NCS-1/frequenin-related protein
Drosophila melanogaster Dmel_CG7641   Neurocalcin
Drosophila melanogaster Dmel_CG5744   Frequenin 1
Drosophila melanogaster Dmel_CG5907   Frequenin 2
Echinococcus granulosus EgrG_000084800   neurocalcin
Echinococcus granulosus EgrG_000093200   EF HAND 1 calcium binding site
Echinococcus multilocularis EmuJ_000084800   neurocalcin
Echinococcus multilocularis EmuJ_000093200   EF HAND 1, calcium binding site
Homo sapiens ENSG00000107130   neuronal calcium sensor 1
Homo sapiens ENSG00000115756   hippocalcin-like 1
Homo sapiens ENSG00000121905   hippocalcin
Homo sapiens ENSG00000104490   neurocalcin delta
Loa Loa (eye worm) LOAG_07360   hypothetical protein
Mus musculus ENSMUSG00000062661   neuronal calcium sensor 1
Mus musculus ENSMUSG00000028785   hippocalcin
Mus musculus ENSMUSG00000071379   hippocalcin-like 1
Mus musculus ENSMUSG00000051359   neurocalcin delta
Oryza sativa 4329060   Os02g0291000
Saccharomyces cerevisiae YDR373W   Frq1p
Schistosoma japonicum Sjp_0031050   Neurocalcin homolog, putative
Schistosoma mansoni Smp_085650   hippocalcin
Schistosoma mansoni Smp_189970   hippocalcin
Schmidtea mediterranea mk4.001169.00  
Schmidtea mediterranea mk4.006210.00   Neuronal calcium sensor 1
Schmidtea mediterranea mk4.009086.00   Putative hippocalcin
Trichomonas vaginalis TVAG_143220   calcium binding proteins, putative
Trichomonas vaginalis TVAG_122450   calcineurin B, putative
Trichomonas vaginalis TVAG_452070   kchip4.2, putative

Essentiality

Bm1_33785 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YDR373W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 23.0% 152 aa Compounds References
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.2966 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_33785 (Brugia malayi), Neuronal calcium sensor family protein 1
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