Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | programmed cell death protein 6 | 0.0016 | 0.2966 | 0.2966 |
Brugia malayi | Probable myosin regulatory light chain | 0.0016 | 0.2966 | 1 |
Schistosoma mansoni | myosin regulatory light chain | 0.0016 | 0.2966 | 1 |
Schistosoma mansoni | myosin light chain | 0.0016 | 0.2966 | 1 |
Loa Loa (eye worm) | myosin Light Chain family member | 0.0016 | 0.2966 | 1 |
Plasmodium vivax | myosin A tail domain interacting protein MTIP, putative | 0.0016 | 0.2966 | 0.5 |
Giardia lamblia | Calmodulin | 0.0016 | 0.2966 | 0.5 |
Echinococcus granulosus | calcyphosin protein | 0.0016 | 0.2966 | 0.2966 |
Plasmodium falciparum | centrin-4 | 0.0016 | 0.2966 | 0.5 |
Loa Loa (eye worm) | myosin regulatory light chain 1 | 0.0016 | 0.2966 | 1 |
Echinococcus granulosus | Calcium binding protein | 0.0016 | 0.2966 | 0.2966 |
Toxoplasma gondii | calmodulin CAM2 | 0.0016 | 0.2966 | 0.5 |
Echinococcus multilocularis | Calcium binding protein | 0.0016 | 0.2966 | 0.2966 |
Onchocerca volvulus | Myosin regulatory light chain 2 homolog | 0.0016 | 0.2966 | 1 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0016 | 0.2966 | 1 |
Brugia malayi | Myosin regulatory light chain 1 | 0.0016 | 0.2966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2966 | 1 |
Schistosoma mansoni | myosin regulatory light chain | 0.0016 | 0.2966 | 1 |
Schistosoma mansoni | calmodulin-related | 0.0016 | 0.2966 | 1 |
Onchocerca volvulus | 0.0016 | 0.2966 | 1 | |
Toxoplasma gondii | calmodulin, putative | 0.0016 | 0.2966 | 0.5 |
Echinococcus granulosus | programmed cell death protein 6 | 0.0016 | 0.2966 | 0.2966 |
Brugia malayi | Neuronal calcium sensor family protein 1 | 0.0016 | 0.2966 | 1 |
Toxoplasma gondii | EF hand domain-containing protein | 0.0016 | 0.2966 | 0.5 |
Toxoplasma gondii | centrin family protein | 0.0016 | 0.2966 | 0.5 |
Toxoplasma gondii | calcium binding protein precursor, putative | 0.0016 | 0.2966 | 0.5 |
Onchocerca volvulus | 0.0016 | 0.2966 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2966 | 1 |
Giardia lamblia | Programmed cell death protein-like protein | 0.0016 | 0.2966 | 0.5 |
Echinococcus multilocularis | Myosin regulatory light chain | 0.0016 | 0.2966 | 0.2966 |
Brugia malayi | RasGEF domain containing protein | 0.0016 | 0.2966 | 1 |
Echinococcus multilocularis | calcyphosin protein | 0.0016 | 0.2966 | 0.2966 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2966 | 1 |
Echinococcus granulosus | Myosin regulatory light chain | 0.0016 | 0.2966 | 0.2966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.