Detailed view for Bm1_29510

Basic information

TDR Targets ID: 237073
Brugia malayi, phosphorylase B kinase beta regulatory chain
Source Database / ID:  GenBank

pI: 8.0051 | Length (AA): 641 | MW (Da): 73970 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00723   Glycosyl hydrolases family 15

Gene Ontology

Mouse over links to read term descriptions.
GO:0005516   calmodulin binding  
GO:0003824   catalytic activity  
GO:0005977   glycogen metabolic process  

Metabolic Pathways

Calcium signaling pathway (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
64 457 2vn4 (A) 34 439 13.00 0 0.52 0.562565 0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133461)

Species Accession Gene Product
Brugia malayi Bm1_29510   phosphorylase B kinase beta regulatory chain
Caenorhabditis elegans CELE_Y67D8A.2   Protein Y67D8A.2, isoform C
Drosophila melanogaster Dmel_CG8475   CG8475 gene product from transcript CG8475-RC
Echinococcus granulosus EgrG_000205300   phosphorylase b kinase regulatory
Echinococcus multilocularis EmuJ_000205300   phosphorylase b kinase regulatory
Homo sapiens ENSG00000102893   phosphorylase kinase, beta
Loa Loa (eye worm) LOAG_11446   hypothetical protein
Mus musculus ENSMUSG00000036879   phosphorylase kinase beta
Onchocerca volvulus OVOC5647   Phosphorylase b kinase regulatory subunit beta homolog
Schistosoma japonicum Sjp_0206700   Probable phosphorylase b kinase regulatory subunit beta, putative
Schistosoma japonicum Sjp_0206710   Phosphorylase b kinase regulatory subunit beta, putative
Schistosoma japonicum Sjp_0311020   Probable phosphorylase b kinase regulatory subunit beta, putative
Schistosoma mansoni Smp_161680   phosphorylase B kinase beta kpbb
Schmidtea mediterranea mk4.002535.09  
Schmidtea mediterranea mk4.002359.01   Phosphorylase b kinase regulatory subunit beta

Essentiality

Bm1_29510 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y67D8A.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphorylase kinase, beta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0576 0.3083 0.3165
0.0367 0.6291 0.6415
0.0712 0.2792 0.2792
0.0617 0.3569 0.361
0.0319 0.6319 0.6379
0.0712 0.2792 0.2792
0.0662 0.4757 0.4922
0.0339 0.6334 0.6399
0.0663 0.2529 0.2529
0.0662 0.4757 0.4922
0.0684 0.3748 0.3817
0.0634 0.2515 0.3206
0.0712 0.333 0.333

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_29510 (Brugia malayi), phosphorylase B kinase beta regulatory chain
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