Detailed view for Bm1_46865

Basic information

TDR Targets ID: 237217
Brugia malayi, Biopterin-dependent aromatic amino acid hydroxylase family protein
Source Database / ID:  GenBank

pI: 6.3653 | Length (AA): 506 | MW (Da): 58519 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00351   Biopterin-dependent aromatic amino acid hydroxylase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016714   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  
GO:0009072   aromatic amino acid family metabolic process  

Metabolic Pathways

Tyrosine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 126 3al0 (C) 6 128 32.00 0.91 0.2 0.0753542 2.84
28 214 3mwb (A) 163 308 20.00 0 0.7 0.197865 0.92
68 498 5den (A) 35 450 42.00 0 1 1.38058 -0.64
163 503 4v06 (A) 148 488 46.00 0 1 1.34121 -1.27
163 452 5j6d (B) 102 391 52.00 0 1 1.05032 -0.35
166 455 5tpg (A) 105 394 48.00 0 1 1.22732 -1.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133353)

Species Accession Gene Product
Brugia malayi Bm1_46865   Biopterin-dependent aromatic amino acid hydroxylase family protein
Caenorhabditis elegans CELE_B0432.5   Protein CAT-2
Drosophila melanogaster Dmel_CG10118   pale
Homo sapiens ENSG00000180176   tyrosine hydroxylase
Loa Loa (eye worm) LOAG_02149   tryptophan hydroxylase 1
Mus musculus ENSMUSG00000000214   tyrosine hydroxylase
Schistosoma japonicum Sjp_0053450   Tyrosine 3-monooxygenase, putative
Schistosoma mansoni Smp_007690   tyrosine 3-monooxygenase
Schmidtea mediterranea mk4.000368.05   Tyrosine 3-monooxygenase
Schmidtea mediterranea mk4.000368.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tyrosine hydroxylase Compounds References
Rattus norvegicus Tyrosine 3-hydroxylase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Tryptophan 5-monooxygenase 1 444 aa 38.4% 438 aa Compounds References
Rattus norvegicus Phenylalanine-4-hydroxylase 453 aa 40.9% 455 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0474 0.571 0.7474
0.0558 0.7711 1
0.0558 0.7711 1
0.0465 0.9589 1
0.0214969 0.418024 0.502675
0.0507 0.6483 1
0.0446 0.3684 0.4546
0.0551 0.6378 0.727
0.0474 0.571 0.7474
0.0206302 0.498289 0.494677
0.0493 0.9911 1
0.0459 0.4901 0.7127
0.0459 0.4901 0.7127
0.0446 0.3759 0.3753
0.0465 0.3624 0.5475
0.0214969 0.418024 0.502675
0.0452 0.4557 0.7286
0.0524 0.5228 0.6005
0.05 0.9588 1
0.0558 0.7711 1
0.0524 0.5228 0.6005

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_46865 (Brugia malayi), Biopterin-dependent aromatic amino acid hydroxylase family protein
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