pI: 6.3261 |
Length (AA): 722 |
MW (Da): 80632 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 96 | 2dmh (A) | 1 | 89 | 34.00 | 0.67 | 0.52 | 0.432939 | 0.18 |
9 | 145 | 3pyc (A) | 10 | 140 | 22.00 | 0 | 1 | 0.457051 | -0.6 |
13 | 146 | 3jzy (A) | 1542 | 1662 | 23.00 | 0 | 0.54 | 0.401896 | -0.61 |
157 | 257 | 1y2i (A) | 3 | 105 | 22.00 | 0 | 0.93 | 0.426189 | -0.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130428)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_00685 | C2 domain containing protein |
Caenorhabditis elegans | CELE_F52H2.7 | Protein F52H2.7 |
Dictyostelium discoideum | DDB_G0269546 | C2 calcium-dependent membrane targeting domain-containing protein |
Drosophila melanogaster | Dmel_CG6454 | CG6454 gene product from transcript CG6454-RC |
Echinococcus granulosus | EgrG_000799100 | C2 calcium dependent membrane targeting |
Echinococcus multilocularis | EmuJ_000799100 | C2 calcium dependent membrane targeting |
Homo sapiens | ENSG00000111731 | C2 calcium-dependent domain containing 5 |
Leishmania braziliensis | LbrM.13.0580 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_130650.1 | C2 domain containing protein, putative |
Leishmania infantum | LinJ.13.0650 | hypothetical protein, conserved |
Leishmania major | LmjF.13.0760 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.13.0760 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_06395 | C2 domain-containing protein |
Mus musculus | ENSMUSG00000030279 | C2 calcium-dependent domain containing 5 |
Onchocerca volvulus | OVOC5589 |
|
Plasmodium berghei | PBANKA_0305200 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0208100 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0413000 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_003855 | hypothetical protein, conserved |
Plasmodium yoelii | PY06292 | fulmal1 |
Plasmodium yoelii | PY03495 | hypothetical protein |
Schistosoma japonicum | Sjp_0044000 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0131600 | similar to Uncharacterized protein KIAA0528 homolog, putative |
Schistosoma japonicum | Sjp_0314790 | similar to Uncharacterized protein KIAA0528 homolog, putative |
Schistosoma mansoni | Smp_133590 | hypothetical protein |
Schmidtea mediterranea | mk4.020079.02 | |
Schmidtea mediterranea | mk4.028373.00 | |
Schmidtea mediterranea | mk4.018587.00 | |
Schmidtea mediterranea | mk4.008967.01 | |
Schmidtea mediterranea | mk4.025011.01 | |
Schmidtea mediterranea | mk4.018071.01 | |
Trypanosoma brucei gambiense | Tbg972.11.4750 | hypothetical protein, conserved,predicted C2 domain protein |
Trypanosoma brucei | Tb927.11.4160 | predicted C2 domain protein |
Trypanosoma congolense | TcIL3000.11.4200 | predicted C2 domain protein |
Trypanosoma cruzi | TcCLB.506737.40 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511855.50 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.1630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.1630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.1630 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.1630 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F52H2.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.