pI: 6.879 |
Length (AA): 635 |
MW (Da): 72919 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 575 | 3rc3 (A) | 72 | 681 | 46.00 | 0 | 1 | 1.51759 | -0.98 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128486)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G39840 | putative ATP-dependent RNA helicase |
Arabidopsis thaliana | AT4G14790 | ATP-dependent RNA helicase |
Babesia bovis | BBOV_IV011410 | ATP-dependent RNA helicase, putative |
Brugia malayi | Bm1_18110 | Helicase conserved C-terminal domain containing protein |
Candida albicans | CaO19.11994 | similar to putative RNA helicase |
Candida albicans | CaO19.4519 | similar to putative RNA helicase |
Caenorhabditis elegans | CELE_C08F8.2 | Protein C08F8.2, isoform C |
Dictyostelium discoideum | DDB_G0278937 | hypothetical protein |
Drosophila melanogaster | Dmel_CG9791 | CG9791 gene product from transcript CG9791-RC |
Homo sapiens | ENSG00000156502 | suppressor of var1, 3-like 1 (S. cerevisiae) |
Leishmania braziliensis | LbrM.20.2180 | RNA helicase, putative,mitochondrial, putative |
Leishmania donovani | LdBPK_342450.1 | ATP-dependent RNA and DNA helicase, mitochondrial, putative |
Leishmania infantum | LinJ.34.2450 | RNA helicase, putative,mitochondrial, putative |
Leishmania major | LmjF.34.2620 | RNA helicase, putative,mitochondrial, putative |
Leishmania mexicana | LmxM.33.2620 | RNA helicase, putative,mitochondrial, putative |
Loa Loa (eye worm) | LOAG_02037 | hypothetical protein |
Mus musculus | ENSMUSG00000020079 | suppressor of var1, 3-like 1 (S. cerevisiae) |
Neospora caninum | NCLIV_032500 | hypothetical protein |
Oryza sativa | 4336047 | Os04g0459800 |
Oryza sativa | 4334089 | Os03g0746500 |
Plasmodium berghei | PBANKA_1122600 | ATP-dependent RNA helicase SUV3, putative |
Plasmodium falciparum | PF3D7_0623700 | ATP-dependent RNA helicase SUV3, putative |
Plasmodium knowlesi | PKNH_1126500 | ATP-dependent RNA helicase SUV3, putative |
Plasmodium vivax | PVX_114300 | ATP-dependent DEAD box helicase, putative |
Plasmodium yoelii | PY04199 | Helicase conserved C-terminal domain, putative |
Saccharomyces cerevisiae | YPL029W | Suv3p |
Trypanosoma brucei gambiense | Tbg972.4.1910 | RNA helicase, putative,mitochondrial, putative |
Trypanosoma brucei | Tb927.4.1990 | ATP-dependent RNA and DNA helicase, mitochondrial, putative |
Trypanosoma congolense | TcIL3000_4_1730 | ATP-dependent RNA and DNA helicase, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.510877.70 | ATP-dependent RNA and DNA helicase, mitochondrial, putative |
Toxoplasma gondii | TGME49_232530 | hypothetical protein |
Theileria parva | TP01_1165 | ATP-dependent DEAD box helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1990 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1990 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.1990 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C08F8.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C08F8.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C08F8.2 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1122600 | Plasmodium berghei | Essential | plasmo |
TGME49_232530 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | suppressor of var1, 3-like 1 (S. cerevisiae) | Compounds | References |