Detailed view for Bm1_50080

Basic information

TDR Targets ID: 238254
Brugia malayi, WW domain containing protein
Source Database / ID:  GenBank

pI: 7.5575 | Length (AA): 772 | MW (Da): 89324 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00397   WW domain
PF00632   HECT-domain (ubiquitin-transferase)

Gene Ontology

Mouse over links to read term descriptions.
GO:0061630   GO:ubiquitin protein ligase activity  

GO:0005622   intracellular  
GO:0016881   acid-amino acid ligase activity  
GO:0005515   protein binding  
GO:0004842   ubiquitin-protein ligase activity  
GO:0006511   ubiquitin-dependent protein catabolic process  
GO:0006464   protein modification process  

Metabolic Pathways

Ubiquitin mediated proteolysis (KEGG)
Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 144 2nq3 (A) 20 144 34.00 0 1 0.575903 -0.72
258 298 2kyk (A) 6 39 74.00 0.00000011 0.47 0.594909 0.35
331 371 2l4j (A) 180 220 56.00 0.00000038 0.58 0.739909 -1.29
337 371 1wr7 (A) 8 41 59.00 0 0.75 0.840437 -2.04
377 766 3olm (A) 388 803 45.00 0 1 1.00198 -0.27
423 767 5hps (A) 541 917 66.00 0 1 1.18269 -0.86
662 764 3pt3 (A) 2693 2792 26.00 0 0.61 0.28452 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127296)

Species Accession Gene Product
Brugia malayi Bm1_48500   NEDD4.2
Brugia malayi Bm1_50080   WW domain containing protein
Candida albicans CaO19.3628   similar to S. cerevisiae RSP5 (YER125W) Nedd4 family E3 ubiquitin ligase
Candida albicans CaO19.11111   similar to S. cerevisiae RSP5 (YER125W) Nedd4 family E3 ubiquitin ligase
Caenorhabditis elegans CELE_Y92H12A.2   Protein Y92H12A.2
Caenorhabditis elegans CELE_Y65B4BR.4   Protein WWP-1, isoform A
Drosophila melanogaster Dmel_CG4244   Suppressor of deltex
Drosophila melanogaster Dmel_CG42279   CG42279 gene product from transcript CG42279-RJ
Echinococcus granulosus EgrG_000163200   NEDD4 E3 ubiquitin protein ligase WWP1
Echinococcus granulosus EgrG_000362800   neural cell expressed developmentally
Echinococcus multilocularis EmuJ_000163200   NEDD4 E3 ubiquitin protein ligase WWP1
Echinococcus multilocularis EmuJ_000362800   neural cell expressed, developmentally
Homo sapiens ENSG00000198373   WW domain containing E3 ubiquitin protein ligase 2
Homo sapiens ENSG00000069869   neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Homo sapiens ENSG00000049759   neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Homo sapiens ENSG00000123124   WW domain containing E3 ubiquitin protein ligase 1
Homo sapiens ENSG00000078747   itchy E3 ubiquitin protein ligase
Loa Loa (eye worm) LOAG_00739   hypothetical protein
Loa Loa (eye worm) LOAG_07133   Nedd4-PD
Loa Loa (eye worm) LOAG_07874   ubiquitin protein ligase
Loa Loa (eye worm) LOAG_07875   hypothetical protein
Mus musculus ENSMUSG00000041058   WW domain containing E3 ubiquitin protein ligase 1
Mus musculus ENSMUSG00000027598   itchy, E3 ubiquitin protein ligase
Mus musculus ENSMUSG00000032216   neural precursor cell expressed, developmentally down-regulated 4
Mus musculus ENSMUSG00000024589   neural precursor cell expressed, developmentally down-regulated gene 4-like
Mus musculus ENSMUSG00000031930   WW domain containing E3 ubiquitin protein ligase 2
Saccharomyces cerevisiae YER125W   NEDD4 family E3 ubiquitin-protein ligase
Schistosoma japonicum Sjp_0066710   ko:K05633 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin, putative
Schistosoma japonicum Sjp_0076060   ko:K10591 E3 ubiquitin-protein ligase NEDD4, putative
Schistosoma japonicum Sjp_0083050   E3 ubiquitin-protein ligase NEDD4-like protein, putative
Schistosoma japonicum Sjp_0117650   expressed protein
Schistosoma mansoni Smp_123180   nedd-4-like E3 ubiquitin-protein ligase
Schistosoma mansoni Smp_175650   E3 ubiquitin-protein ligase nedd-4
Schmidtea mediterranea mk4.006191.01   E3 ubiquitin-protein ligase NEDD4-like
Schmidtea mediterranea mk4.006191.03   E3 ubiquitin-protein ligase NEDD4
Schmidtea mediterranea mk4.002458.02   E3 ubiquitin-protein ligase
Schmidtea mediterranea mk4.002458.05  
Schmidtea mediterranea mk4.002458.04   NEDD4-like E3 ubiquitin-protein ligase WWP1
Schmidtea mediterranea mk4.002284.00   E3 ubiquitin-protein ligase
Schmidtea mediterranea mk4.003500.01   E3 ubiquitin-protein ligase
Schmidtea mediterranea mk4.003796.00  
Schmidtea mediterranea mk4.003796.02   E3 ubiquitin-protein ligase
Schmidtea mediterranea mk4.003500.02  
Schmidtea mediterranea mk4.027399.00   E3 ubiquitin-protein ligase NEDD4
Schmidtea mediterranea mk4.002815.04   NEDD4-like E3 ubiquitin-protein ligase WWP1
Schmidtea mediterranea mk4.002815.02   E3 ubiquitin-protein ligase
Schmidtea mediterranea mk4.002569.01   E3 ubiquitin-protein ligase

Essentiality

Bm1_50080 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y65B4BR.4 Caenorhabditis elegans embryonic lethal wormbase
YER125W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0072 0.2639 0.9142
0.0057 0.3491 0.3491
0.005 0.2612 0.9039
0.0058 0.5 0.5
0.0121 1 1
0.0125 0.3893 0.3893
0.0107 0.5 0.5
0.0071 0.2549 1
0.0018 0.5 0.5
0.0109 0.4866 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_50080 (Brugia malayi), WW domain containing protein
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