Detailed view for Bm1_20435

Basic information

TDR Targets ID: 238373
Brugia malayi, CG6179-PA
Source Database / ID:  GenBank

pI: 8.619 | Length (AA): 321 | MW (Da): 36558 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF15906   Zinc-finger of nitric oxide synthase-interacting protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0061630   GO:ubiquitin protein ligase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 113 4ayc (A) 395 483 20.00 0 0.41 0.36626 -0.82
46 86 4wz3 (B) 37 76 43.00 0.18 0.91 0.671726 -0.52
241 295 4s3o (B) 46 102 13.00 0.21 0.12 0.29774 -0.32
261 291 4orh (C) 417 447 16.00 0.041 0.04 0.280973 -0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129487)

Species Accession Gene Product
Arabidopsis thaliana AT1G61620   zinc Finger RING C3H2C3-type protein
Babesia bovis BBOV_II003220   conserved hypothetical protein
Brugia malayi Bm1_20435   CG6179-PA
Caenorhabditis elegans CELE_R05G6.4   Protein R05G6.4
Dictyostelium discoideum DDB_G0270882   hypothetical protein
Drosophila melanogaster Dmel_CG6179   CG6179 gene product from transcript CG6179-RA
Echinococcus granulosus EgrG_000625000   nitric oxide synthase interacting protein
Echinococcus multilocularis EmuJ_000625300   nitric oxide synthase interacting protein
Echinococcus multilocularis EmuJ_000625000   nitric oxide synthase interacting protein
Homo sapiens ENSG00000142546   nitric oxide synthase interacting protein
Loa Loa (eye worm) LOAG_08646   hypothetical protein
Mus musculus ENSMUSG00000003421   nitric oxide synthase interacting protein
Neospora caninum NCLIV_067510   hypothetical protein, conserved
Oryza sativa 4332437   Os03g0279900
Plasmodium berghei PBANKA_1232800   NOSIP domain-containing protein, putative
Plasmodium falciparum PF3D7_0518000   NOSIP domain-containing protein, putative
Plasmodium knowlesi PKNH_1015200   NOSIP domain-containing protein, putative
Plasmodium yoelii PY01617   hypothetical protein
Schistosoma japonicum Sjp_0303900   Nitric oxide synthase-interacting protein, putative
Schistosoma mansoni Smp_090830   nitric oxide synthase interacting protein
Schmidtea mediterranea mk4.002255.01   Nitric oxide synthase-interacting protein homolog
Schmidtea mediterranea mk4.018825.00   Nitric oxide synthase-interacting protein homolog
Toxoplasma gondii TGME49_278490   Zn-finger, RING domain containing protein
Theileria parva TP04_0271   hypothetical protein, conserved
Trichomonas vaginalis TVAG_322550   conserved hypothetical protein

Essentiality

Bm1_20435 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1232800 Plasmodium berghei Dispensable plasmo
TGME49_278490 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_20435 (Brugia malayi), CG6179-PA
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