Detailed view for Bm1_00545

Basic information

TDR Targets ID: 239249
Brugia malayi, T-complex protein 1, zeta subunit
Source Database / ID:  GenBank

pI: 7.6333 | Length (AA): 540 | MW (Da): 59178 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00118   TCP-1/cpn60 chaperonin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0044267   cellular protein metabolic process  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 532 4b2t (Z) 4 525 64.00 0 1 1.61753 0.03
208 374 1ass (A) 1 152 36.00 0 1 0.699459 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127428)

Species Accession Gene Product
Arabidopsis thaliana AT3G02530   TCP-1/cpn60 chaperonin family protein
Arabidopsis thaliana AT5G16070   TCP-1/cpn60 chaperonin family protein
Babesia bovis BBOV_IV000230   T-complex protein 1 zeta subunit
Brugia malayi Bm1_00545   T-complex protein 1, zeta subunit
Candida albicans CaO19.3126   similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Candida albicans CaO19.10638   similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Caenorhabditis elegans CELE_F01F1.8   Protein CCT-6, isoform B
Cryptosporidium hominis Chro.70466   chaperonin
Cryptosporidium parvum cgd7_4220   TCP-1 chaperonin
Dictyostelium discoideum DDB_G0277493   chaperonin containing TCP1 zeta subunit
Drosophila melanogaster Dmel_CG8231   T-cp1zeta
Echinococcus granulosus EgrG_000143600   T complex protein 1 subunit zeta
Entamoeba histolytica EHI_178980   hypothetical protein
Entamoeba histolytica EHI_125800   chaperonin-containing TCP-1, zeta subunit, putative
Echinococcus multilocularis EmuJ_000143600   T complex protein 1 subunit zeta
Echinococcus multilocularis EmuJ_000140900   T complex protein 1 subunit zeta
Giardia lamblia GL50803_10231   TCP-1 chaperonin subunit zeta
Homo sapiens ENSG00000146731   chaperonin containing TCP1, subunit 6A (zeta 1)
Homo sapiens ENSG00000132141   chaperonin containing TCP1, subunit 6B (zeta 2)
Leishmania braziliensis LbrM.13.1520   chaperonin TCP20, putative
Leishmania donovani LdBPK_131400.1   chaperonin TCP20, putative
Leishmania infantum LinJ.13.1400   chaperonin TCP20, putative
Leishmania major LmjF.13.1660   chaperonin TCP20, putative
Leishmania mexicana LmxM.13.1660   chaperonin TCP20, putative
Loa Loa (eye worm) LOAG_01700   T-complex protein 1
Mus musculus ENSMUSG00000020698   chaperonin containing Tcp1, subunit 6b (zeta)
Mus musculus 12466   chaperonin containing Tcp1, subunit 6a (zeta)
Neospora caninum NCLIV_011140   GL18351, related
Oryza sativa 4337802   Os05g0147400
Plasmodium berghei PBANKA_0107300   T-complex protein 1 subunit zeta, putative
Plasmodium falciparum PF3D7_0608700   T-complex protein 1 subunit zeta
Plasmodium knowlesi PKNH_1141500   T-complex protein 1 subunit zeta, putative
Plasmodium vivax PVX_113595   T-complex protein 1 subunit zeta, putative
Plasmodium yoelii PY02258   putative chaperonin
Saccharomyces cerevisiae YDR188W   Cct6p
Schistosoma japonicum Sjp_0095780   ko:K09498 T-complex protein 1 subunit zeta, putative
Schistosoma mansoni Smp_004990   chaperonin containing t-complex protein 1 zeta subunit tcpz
Schmidtea mediterranea mk4.000511.03   GH13725p
Schmidtea mediterranea mk4.002582.01   T-complex protein 1 subunit zeta
Trypanosoma brucei gambiense Tbg972.11.3610   T-complex protein 1, zeta subunit, putative
Trypanosoma brucei Tb927.11.3240   T-complex protein 1, zeta subunit, putative
Trypanosoma congolense TcIL3000.11.3010   T-complex protein 1, zeta subunit, putative
Trypanosoma congolense TcIL3000_0_41470   T-complex protein 1, zeta subunit, putative
Trypanosoma cruzi TcCLB.509583.10   chaperonin TCP20, putative
Toxoplasma gondii TGME49_318410   TCP-1 chaperonin, putative
Theileria parva TP02_0937   chaperonin 60 kDa, putative
Trichomonas vaginalis TVAG_303600   chaperonin containing t-complex protein 1, zeta subunit, tcpz, putative

Essentiality

Bm1_00545 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.0750 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0750 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.0750 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.0750 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F01F1.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F01F1.8 Caenorhabditis elegans larval arrest wormbase
CELE_F01F1.8 Caenorhabditis elegans larval lethal wormbase
CELE_F01F1.8 Caenorhabditis elegans sterile wormbase
YDR188W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0107300 Plasmodium berghei Slow plasmo
TGME49_318410 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaaca fascicularis T-complex protein 1 subunit beta 535 aa 27.7% 517 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00545 (Brugia malayi), T-complex protein 1, zeta subunit
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