pI: 5.3809 |
Length (AA): 449 |
MW (Da): 51123 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 437 | 5ihe (A) | 180 | 611 | 17.00 | 0 | 1 | 1.00327 | 0.85 |
20 | 440 | 3e0j (A) | 24 | 452 | 31.00 | 0 | 1 | 1.20264 | 0 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127874)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G42120 | DNA polymerase delta subunit 2 |
Babesia bovis | BBOV_III004800 | DNA polymerase alpha subunit B family protein |
Brugia malayi | Bm1_25190 | pold2-prov protein |
Candida albicans | CaO19.3960 | similar to DNA polymerase delta small subunit. |
Candida albicans | CaO19.11442 | similar to DNA polymerase delta small subunit. |
Caenorhabditis elegans | CELE_F12F6.7 | Protein F12F6.7 |
Cryptosporidium hominis | Chro.80190 | hypothetical protein |
Cryptosporidium parvum | cgd8_1620 | DNA polymerase delta2, inactive calcineurin like phosphatase subunit |
Dictyostelium discoideum | DDB_G0281641 | DNA polymerase delta subunit 2 |
Drosophila melanogaster | Dmel_CG12018 | CG12018 gene product from transcript CG12018-RA |
Echinococcus granulosus | EgrG_000520300 | dna polymerase subunit delta |
Entamoeba histolytica | EHI_141410 | DNA polymerase epsilon subunit B domain-containing protein |
Echinococcus multilocularis | EmuJ_000520300 | dna polymerase subunit delta dna polymerase delta subunit |
Giardia lamblia | GL50803_10775 | Hypothetical protein |
Homo sapiens | ENSG00000106628 | polymerase (DNA directed), delta 2, accessory subunit |
Leishmania braziliensis | LbrM.25.2060 | DNA polymerase delta subunit 2, putative |
Leishmania donovani | LdBPK_251450.1 | DNA polymerase delta subunit 2, putative |
Leishmania infantum | LinJ.25.1450 | DNA polymerase delta subunit 2, putative |
Leishmania major | LmjF.25.1410 | DNA polymerase delta subunit 2, putative |
Leishmania mexicana | LmxM.25.1410 | DNA polymerase delta subunit 2, putative |
Loa Loa (eye worm) | LOAG_12274 | pold2-prov protein |
Mus musculus | ENSMUSG00000020471 | polymerase (DNA directed), delta 2, regulatory subunit |
Neospora caninum | NCLIV_033420 | hypothetical protein |
Oryza sativa | 4331489 | Os03g0128500 |
Onchocerca volvulus | OVOC12896 | Putative DNA polymerase delta small subunit |
Onchocerca volvulus | OVOC7945 | Putative DNA polymerase delta small subunit |
Onchocerca volvulus | OVOC7932 | Putative DNA polymerase delta small subunit |
Onchocerca volvulus | OVOC12943 | Putative DNA polymerase delta small subunit |
Plasmodium berghei | PBANKA_0406300 | DNA polymerase delta small subunit, putative |
Plasmodium falciparum | PF3D7_0308000 | DNA polymerase delta small subunit, putative |
Plasmodium knowlesi | PKNH_0834700 | DNA polymerase delta small subunit, putative |
Plasmodium vivax | PVX_119520 | DNA polymerase delta small subunit, putative |
Plasmodium yoelii | PY01936 | hypothetical protein |
Saccharomyces cerevisiae | YJR006W | Pol31p |
Schistosoma japonicum | Sjp_0026840 | hypothetical protein |
Schistosoma japonicum | Sjp_0026860 | ko:K02328 DNA polymerase delta subunit 2, putative |
Schistosoma mansoni | Smp_076660 | DNA polymerase delta small subunit |
Schmidtea mediterranea | mk4.002099.01 | |
Trypanosoma brucei gambiense | Tbg972.3.860 | DNA polymerase delta subunit 2, putative |
Trypanosoma brucei | Tb927.3.1130 | DNA polymerase delta subunit 2, putative |
Trypanosoma congolense | TcIL3000_3_360 | DNA polymerase delta subunit 2, putative |
Trypanosoma cruzi | TcCLB.503879.10 | DNA polymerase delta subunit 2, putative |
Trypanosoma cruzi | TcCLB.509455.70 | DNA polymerase delta subunit 2, putative |
Toxoplasma gondii | TGME49_233820 | DNA polymerase epsilon subunit B protein |
Theileria parva | TP02_0469 | DNA polymerase delta small subunit, putative |
Trichomonas vaginalis | TVAG_292850 | DNA polymerase delta small subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.1130 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.1130 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.1130 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.1130 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F12F6.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F12F6.7 | Caenorhabditis elegans | slow growth | wormbase |
YJR006W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_233820 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.