Detailed view for Bm1_47550

Basic information

TDR Targets ID: 241408
Brugia malayi, C2 domain containing protein
Source Database / ID:  GenBank

pI: 10.4543 | Length (AA): 371 | MW (Da): 44000 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF06398   Integral peroxisomal membrane peroxin

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 143 2ep6 (A) 89 217 47.00 0.0000062 1 0.911909 -0.06
28 138 2nsq (A) 25 150 32.00 0 1 0.628291 -0.53
28 122 2bwq (A) 747 853 35.00 0.00014 0.52 0.407265 0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127860)

Species Accession Gene Product
Arabidopsis thaliana AT4G11610   C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
Arabidopsis thaliana AT5G48060   C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
Arabidopsis thaliana AT3G03680   C2 and plant phosphoribosyltransferase domain-containing protein
Arabidopsis thaliana AT1G51570   calcium-dependent lipid-binding (CaLB domain) plant phosphoribosyltransferase family protein
Arabidopsis thaliana AT1G04150   C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
Arabidopsis thaliana AT5G06850   FT-interacting protein 1
Arabidopsis thaliana AT1G22610   C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
Arabidopsis thaliana AT3G61300   C2 calcium/lipid-binding and phosphoribosyltransferase C-terminal domain-containing protein
Arabidopsis thaliana AT1G74720   putative transmembrane protein QUIRKY
Arabidopsis thaliana AT4G20080   calcium-dependent lipid-binding domain-containing plant phosphoribosyltransferase-like protein
Arabidopsis thaliana AT4G00700   C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
Arabidopsis thaliana AT5G17980   C2 calcium/lipid-binding and phosphoribosyltransferase C-terminal domain-containing protein
Arabidopsis thaliana AT3G57880   C2 domain-containing plant phosphoribosyltransferase-like protein
Arabidopsis thaliana AT5G12970   calcium-dependent lipid-binding domain-containing plant phosphoribosyltransferase-like protein
Brugia malayi Bm1_47550   C2 domain containing protein
Caenorhabditis elegans CELE_D2092.1   Protein D2092.1, isoform A
Drosophila melanogaster Dmel_CG15078   Multiple C2 domain and transmembrane region protein
Echinococcus granulosus EgrG_001002200   multiple C2 and transmembrane domain containing protein
Echinococcus granulosus EgrG_001002000   multiple C2 and transmembrane domain containing protein
Echinococcus multilocularis EmuJ_001002000   multiple C2 and transmembrane domain containing protein
Echinococcus multilocularis EmuJ_001002200   multiple C2 and transmembrane domain containing protein
Homo sapiens ENSG00000175471   multiple C2 domains, transmembrane 1
Homo sapiens ENSG00000140563   multiple C2 domains, transmembrane 2
Loa Loa (eye worm) LOAG_05813   hypothetical protein
Mus musculus ENSMUSG00000032776   multiple C2 domains, transmembrane 2
Mus musculus 78771   multiple C2 domains, transmembrane 1
Oryza sativa 4336135   Os04g0472900
Oryza sativa 4330234   Os02g0663900
Oryza sativa 4342481   Os07g0165100
Oryza sativa 4338582   Os05g0370600
Oryza sativa 4337448   Os04g0683800
Oryza sativa 4337508   Os04g0691800
Oryza sativa 4331135   Os02g0816000
Oryza sativa 4341529   Os06g0614000
Oryza sativa 4327662   Os01g0587300
Oryza sativa 9270377   Os12g0187575
Oryza sativa 4338873   Os05g0429700
Oryza sativa 4343239   Os07g0483500
Schistosoma japonicum Sjp_0092260   IPR000008,C2 calcium-dependent membrane targeting;IPR008973,C2 calcium/lipid-binding region, CaLB,domain-containing
Schistosoma japonicum Sjp_0132830   expressed protein
Schistosoma mansoni Smp_130920   mctp-related
Trichomonas vaginalis TVAG_485570   synaptotagmin, putative
Trichomonas vaginalis TVAG_054530   ion channel nompc, putative
Trichomonas vaginalis TVAG_038690   synaptotagmin 1,2, putative
Trichomonas vaginalis TVAG_605770   conserved hypothetical protein

Essentiality

Bm1_47550 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_D2092.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0109 0.4866 1
0.0125 0.3893 0.3893
0.0107 0.5 0.5
0.0071 0.2549 1
0.0018 0.5 0.5
0.0121 1 1
0.0057 0.3491 0.3491
0.0072 0.2639 0.9142
0.005 0.2612 0.9039
0.0058 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_47550 (Brugia malayi), C2 domain containing protein
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