Detailed view for LmjF.31.0790

Basic information

TDR Targets ID: 24411
Leishmania major, c2 domain protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.6538 | Length (AA): 288 | MW (Da): 31371 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 131 1gmi (A) 5 136 16.00 0 0.36 0.47 -0.62
1 121 3jzy (A) 1540 1658 24.00 0 0.53 0.623239 -0.6
2 121 1djx (A) 629 752 25.00 0 0.66 0.667767 -0.6
2 125 2zkm (X) 678 799 20.00 0 0.85 0.535656 -0.2
170 222 5ctd (A) 2 42 49.00 0.97 0.1 0.319228 0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129108)

Species Accession Gene Product
Arabidopsis thaliana AT4G34150   calcium-dependent lipid-binding domain-containing protein
Dictyostelium discoideum DDB_G0294603   C2 domain-containing protein
Dictyostelium discoideum DDB_G0278101   C2 domain-containing protein
Dictyostelium discoideum DDB_G0272734   hypothetical protein
Dictyostelium discoideum DDB_G0290755   C2 domain-containing protein
Dictyostelium discoideum DDB_G0279935   hypothetical protein
Dictyostelium discoideum DDB_G0290753   C2 domain-containing protein
Dictyostelium discoideum DDB_G0272752   C2 domain-containing protein
Entamoeba histolytica EHI_118130   C2 domain containing protein
Entamoeba histolytica EHI_059860   C2 domain containing protein
Entamoeba histolytica EHI_015290   C2 domain protein, putative
Leishmania braziliensis LbrM.31.0850   hypothetical protein, conserved
Leishmania braziliensis LbrM.31.0970   c2 domain protein, putative
Leishmania donovani LdBPK_310710.1   C2 domain containing protein, putative
Leishmania donovani LdBPK_310820.1   c2 domain protein, putative
Leishmania infantum LinJ.31.0820   c2 domain protein, putative
Leishmania infantum LinJ.31.0710   hypothetical protein, conserved
Leishmania major LmjF.31.0790   c2 domain protein, putative
Leishmania major LmjF.31.0680   hypothetical protein, conserved
Leishmania mexicana LmxM.30.0680   hypothetical protein, conserved
Leishmania mexicana LmxM.30.0790   c2 domain protein, putative
Neospora caninum NCLIV_065990   C2 domain-containing protein, putative
Neospora caninum NCLIV_022080   hypothetical protein
Oryza sativa 4337436   Os04g0682100
Trypanosoma brucei gambiense Tbg972.8.8470   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.8150   C2 domain containing protein, putative
Trypanosoma congolense TcIL3000_0_20280   C2 domain containing protein, putative
Trypanosoma congolense TcIL3000_4_3610   C2 domain containing protein, putative
Trypanosoma congolense TcIL3000_8_8300   C2 domain containing protein, putative
Trypanosoma cruzi TcCLB.460747.30   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509895.60   hypothetical protein, conserved
Toxoplasma gondii TGME49_249870   hypothetical protein
Toxoplasma gondii TGME49_202830   Elicitor-responsive protein, putative
Trichomonas vaginalis TVAG_193820   Circumsporozoite protein precursor, putative
Trichomonas vaginalis TVAG_000170   conserved hypothetical protein
Trichomonas vaginalis TVAG_444780   Proline-rich protein, putative
Trichomonas vaginalis TVAG_215950   synaptotagmin, putative
Trichomonas vaginalis TVAG_002900   conserved hypothetical protein
Trichomonas vaginalis TVAG_347440   annexin VII, putative
Trichomonas vaginalis TVAG_145560   conserved hypothetical protein
Trichomonas vaginalis TVAG_041990   conserved hypothetical protein
Trichomonas vaginalis TVAG_063200   conserved hypothetical protein
Trichomonas vaginalis TVAG_456580   splicing factor 3A subunit, putative
Trichomonas vaginalis TVAG_292610   conserved hypothetical protein
Trichomonas vaginalis TVAG_024730   conserved hypothetical protein

Essentiality

LmjF.31.0790 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.8150 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.8150 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.8150 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.8150 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_202830 Toxoplasma gondii Probably non-essential sidik
TGME49_249870 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0121 1 1
0.0057 0.3491 0.5
0.0072 0.2639 1
0.005 0.2612 0.5
0.0058 0.5 0.5
0.0109 0.4866 0.5
0.0107 0.5 0.5
0.0125 0.3893 0.3893
0.0071 0.2549 1
0.0018 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.31.0790 (Leishmania major), c2 domain protein, putative
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