Detailed view for Bm1_53305

Basic information

TDR Targets ID: 244682
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 4.6558 | Length (AA): 106 | MW (Da): 12070 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128837)

Species Accession Gene Product
Brugia malayi Bm1_19030   Amylo-alpha-1,6-glucosidase family protein
Brugia malayi Bm1_53305   hypothetical protein
Candida albicans CaO19.8363   similar to S. cerevisiae GDB1 (YPR184W) glycogen debranching enzyme
Candida albicans CaO19.744   similar to S. cerevisiae GDB1 (YPR184W) glycogen debranching enzyme
Caenorhabditis elegans CELE_R06A4.8   Protein AGL-1
Cryptosporidium hominis Chro.60114   glycine-rich protein 2 (GRP2)
Cryptosporidium parvum cgd6_880   Gdb1p; glycogen debranching enzyme
Dictyostelium discoideum DDB_G0287569   glycogen debranching enzyme
Drosophila melanogaster Dmel_CG9485   CG9485 gene product from transcript CG9485-RF
Echinococcus granulosus EgrG_000644500   glycogen debranching enzyme
Entamoeba histolytica EHI_098360   glycogen debranching enzyme, putative
Echinococcus multilocularis EmuJ_000644500   glycogen debranching enzyme
Giardia lamblia GL50803_10885   4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase
Homo sapiens ENSG00000162688   amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Loa Loa (eye worm) LOAG_11769   amylo-alpha-1,6-glucosidase
Loa Loa (eye worm) LOAG_07652   hypothetical protein
Mus musculus ENSMUSG00000033400   amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Neospora caninum NCLIV_046100   glycogen debranching enzyme, putative
Saccharomyces cerevisiae YPR184W   bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase
Schistosoma japonicum Sjp_0097780   ko:K00705 4-alpha-glucanotransferase [EC2.4.1.25], putative
Schistosoma japonicum Sjp_0209490   Glycogen debranching enzyme, putative
Schistosoma japonicum Sjp_0209480   Glycogen debranching enzyme, putative
Schistosoma japonicum Sjp_0209500   Glycogen debranching enzyme, putative
Schistosoma mansoni Smp_007650   hypothetical protein
Schistosoma mansoni Smp_007640   hypothetical protein
Schmidtea mediterranea mk4.006507.01   Glycogen debranching enzyme
Schmidtea mediterranea mk4.006507.00   Glycogen debranching enzyme
Toxoplasma gondii TGME49_226910   Amylo-alpha-1,6-glucosidase
Trichomonas vaginalis TVAG_143490   glycogen debranching enzyme, putative
Trichomonas vaginalis TVAG_330630   glycogen debranching enzyme, putative

Essentiality

Bm1_53305 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R06A4.8 Caenorhabditis elegans embryonic lethal wormbase
TGME49_226910 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Oryctolagus cuniculus Glycogen debranching enzyme Compounds References
Homo sapiens amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_53305 (Brugia malayi), hypothetical protein
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