Detailed view for Bm1_45300

Basic information

TDR Targets ID: 244688
Brugia malayi, SAP domain containing protein
Source Database / ID:  GenBank

pI: 10.4855 | Length (AA): 249 | MW (Da): 27434 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02037   SAP domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 49 2do1 (A) 3 50 33.00 0.0056 1 0.738571 -1.21
2 45 1zrj (A) 0 42 41.00 0.024 1 0.822507 -1.41
6 40 1jeq (A) 573 607 34.00 0 1 0.668062 -1.13
75 248 1t11 (A) 113 325 28.00 0.77 0.27 0.654395 1.42
190 243 5hmo (A) 814 863 26.00 0.19 0.01 0.419667 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129159)

Species Accession Gene Product
Arabidopsis thaliana AT5G02770   hypothetical protein
Babesia bovis BBOV_I003290   hypothetical protein
Brugia malayi Bm1_45300   SAP domain containing protein
Candida albicans CaO19.7830   suppressor of the transcriptional defect of Hpr1
Candida albicans CaO19.200   suppressor of the transcriptional defect of Hpr1
Caenorhabditis elegans CELE_Y53G8AR.6   Protein Y53G8AR.6
Cryptosporidium hominis Chro.30173   hypothetical protein
Cryptosporidium parvum cgd3_1430   hypothetical protein
Dictyostelium discoideum DDB_G0279663   SAP DNA-binding domain-containing protein
Dictyostelium discoideum DDB_G0277405   SAP DNA-binding domain-containing protein
Drosophila melanogaster Dmel_CG8149   CG8149 gene product from transcript CG8149-RA
Echinococcus granulosus EgrG_000294500   SAP domain containing ribonucleoprotein
Echinococcus multilocularis EmuJ_000294500   SAP domain containing ribonucleoprotein
Homo sapiens ENSG00000205323   SAP domain containing ribonucleoprotein
Loa Loa (eye worm) LOAG_06284   hypothetical protein
Mus musculus ENSMUSG00000078427   SAP domain containing ribonucleoprotein
Neospora caninum NCLIV_022050   mitochondrial carrier domain-containing protein, putative
Oryza sativa 4332457   Os03g0283300
Onchocerca volvulus OVOC8429  
Plasmodium berghei PBANKA_0813500   SAP domain-containing protein, putative
Plasmodium falciparum PF3D7_0912500   SAP domain-containing protein, putative
Plasmodium knowlesi PKNH_0710400   SAP domain-containing protein, putative
Plasmodium vivax PVX_099060   hypothetical protein, conserved
Plasmodium yoelii PY07463   hypothetical protein
Saccharomyces cerevisiae YER063W   Tho1p
Schistosoma japonicum Sjp_0039100   IPR003034,DNA-binding SAP,domain-containing
Schistosoma mansoni Smp_078090.2   hypothetical protein
Schistosoma mansoni Smp_191380   hypothetical protein
Schmidtea mediterranea mk4.000933.12   CIP29 protein
Toxoplasma gondii TGME49_202870   SAP domain-containing protein
Theileria parva TP03_0177   hypothetical protein
Theileria parva TP03_0178   hypothetical protein

Essentiality

Bm1_45300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y53G8AR.6 Caenorhabditis elegans embryonic lethal wormbase
TGME49_202870 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_45300 (Brugia malayi), SAP domain containing protein
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