Detailed view for PF3D7_1416900

Basic information

TDR Targets ID: 2500
Plasmodium falciparum, prefoldin subunit 2, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.809 | Length (AA): 147 | MW (Da): 16653 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01920   Prefoldin subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0016272   prefoldin complex  
GO:0051082   unfolded protein binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 117 1fxk (A) 5 109 11.00 0 0.57 0.92 -0.66
2 115 4uos (A) 37 149 25.00 0.84 0.84 1.17121 -1.11
21 117 2zdi (A) 14 110 19.00 0.00000097 0.79 0.989364 -1.12
21 103 2zdi (A) 17 106 39.00 0.0024 0.63 0.839326 -0.11
24 110 3aei (A) 8 94 20.00 0.0053 0.94 0.947337 -1.13
79 143 3qh9 (A) 14 78 8.00 0.71 0 0.633677 -1.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, gametocyte, sporozoite, early ring, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 48 hs, Sporozoite. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128303)

Species Accession Gene Product
Arabidopsis thaliana AT3G22480   putative prefoldin subunit 2
Babesia bovis BBOV_II001170   KE2 family protein, putative
Brugia malayi Bm1_14985   KE2 family protein
Candida albicans CaO19.2305   similar to S. cerevisiae GIM4 (YEL003W) prefoldin subunit 2, component of Gim protein complex involved in tubulin folding
Candida albicans CaO19.9841   similar to S. cerevisiae GIM4 (YEL003W) prefoldin subunit 2, component of Gim protein complex involved in tubulin folding
Caenorhabditis elegans CELE_H20J04.5   Protein PFD-2
Cryptosporidium hominis Chro.70511   hypothetical protein
Cryptosporidium parvum cgd7_4630   hypothetical protein
Dictyostelium discoideum DDB_G0267594   prefoldin beta-like domain containing protein
Drosophila melanogaster Dmel_CG6302   lethal (3) 01239
Echinococcus granulosus EgrG_000722800   prefoldin subunit 2
Entamoeba histolytica EHI_113900   prefoldin subunit 2, putative
Echinococcus multilocularis EmuJ_000722800   prefoldin subunit 2
Giardia lamblia GL50803_11713   Prefoldin subunit 2
Homo sapiens ENSG00000143256   prefoldin subunit 2
Leishmania braziliensis LbrM.09.0750   prefoldin subunit 2, putative
Leishmania donovani LdBPK_090720.1   prefoldin subunit 2, putative
Leishmania infantum LinJ.09.0720   prefoldin subunit 2, putative
Leishmania major LmjF.09.0670   prefoldin subunit 2, putative
Leishmania mexicana LmxM.09.0670   prefoldin subunit 2, putative
Loa Loa (eye worm) LOAG_03812   KE2 family protein
Mus musculus 18637   prefoldin 2
Neospora caninum NCLIV_000520   hypothetical protein, conserved
Oryza sativa 4352232   Os12g0485800
Oryza sativa 4350745   Os11g0568500
Plasmodium berghei PBANKA_1025800   prefoldin subunit 2, putative
Plasmodium falciparum PF3D7_1416900   prefoldin subunit 2, putative
Plasmodium knowlesi PKNH_1341200   prefoldin subunit 2, putative
Plasmodium vivax PVX_085605   prefoldin subunit 2, putative
Plasmodium yoelii PY05659   probable prefoldin subunit 2
Saccharomyces cerevisiae YEL003W   Gim4p
Schistosoma japonicum Sjp_0012120   ko:K09549 prefoldin subunit 2, putative
Schistosoma mansoni Smp_030290   prefoldin subunit 2
Schmidtea mediterranea mk4.003861.00  
Schmidtea mediterranea mk4.005213.01  
Trypanosoma brucei gambiense Tbg972.11.14140   prefoldin subunit 2, putative
Trypanosoma brucei Tb927.11.12680   prefoldin subunit 2, putative
Trypanosoma cruzi TcCLB.511483.40   prefoldin subunit 2, putative
Trypanosoma cruzi TcCLB.508777.180   prefoldin subunit 2, putative
Toxoplasma gondii TGME49_293580   prefoldin subunit protein
Theileria parva TP04_0469   hypothetical protein, conserved
Trichomonas vaginalis TVAG_084710   prefoldin subunit, putative

Essentiality

PF3D7_1416900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.4520 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.4520 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_H20J04.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_H20J04.5 Caenorhabditis elegans larval arrest wormbase
CELE_H20J04.5 Caenorhabditis elegans larval lethal wormbase
CELE_H20J04.5 Caenorhabditis elegans sterile wormbase
TGME49_293580 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1416900 (Plasmodium falciparum), prefoldin subunit 2, putative
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