Detailed view for PF3D7_1423200

Basic information

TDR Targets ID: 2554
Plasmodium falciparum, peptidyl-prolyl cis-trans isomerase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.5174 | Length (AA): 446 | MW (Da): 52663 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0016018   cyclosporin A binding  
GO:0005575   cellular_component  
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 174 2hq6 (A) 8 171 45.00 0 1 1.07 -1.6
9 188 1zkc (A) 276 452 36.00 0 1 0.98 -1.45
16 169 2fu0 (A) 9 158 41.00 0 1 1 -1.66
8 180 3bkp (A) 17 202 48.00 0 1 1.03599 -1.29
16 169 2fu0 (A) 9 158 41.00 0 1 0.943891 -1.15
254 427 4uos (A) 2 180 18.00 0.0012 0.03 0.720235 -1.88
9 188 1zkc (A) 276 452 36.00 0 1 0.934137 -1.05
11 179 3bkp (A) 20 201 50.00 0 1 1.05501 -1.3
217 331 1na0 (A) 10 124 7.00 0.33 0 0.492693 -2.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile early trophozoite, Ring, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, sporozoite, early ring, early schizont, late trophozoite, Oocyst, Sporozoite, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, gametocyte, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs. Otto TD
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_129157)

Species Accession Gene Product
Arabidopsis thaliana AT4G33060   cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein
Babesia bovis BBOV_II006340   peptidyl-prolyl cis-trans isomerase, cyclophilin-type family protein
Brugia malayi Bm1_29125   cyclophilin-type peptidyl-prolyl cis-trans isomerase-16, Bmcyp-16
Caenorhabditis elegans CELE_Y17G7B.9   Protein CYN-16
Dictyostelium discoideum DDB_G0268358   cyclophilin-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG10907   CG10907 gene product from transcript CG10907-RA
Echinococcus granulosus EgrG_000684950   peptidyl prolyl cis trans isomerase CWC27
Echinococcus multilocularis EmuJ_000684950   peptidyl prolyl cis trans isomerase CWC27
Homo sapiens ENSG00000153015   CWC27 spliceosome-associated protein homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_11869   hypothetical protein
Loa Loa (eye worm) LOAG_09606   cyclophilin-type peptidyl-prolyl cis-trans isomerase-16
Mus musculus ENSMUSG00000021715   CWC27 spliceosome-associated protein homolog (S. cerevisiae)
Neospora caninum NCLIV_017250   Peptidylprolyl isomerase (Cyclophilin)-like 2, related
Oryza sativa 4324199   Os01g0582400
Plasmodium berghei PBANKA_1020200   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium falciparum PF3D7_1423200   peptidyl-prolyl cis-trans isomerase
Plasmodium knowlesi PKNH_1334800   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium vivax PVX_085320   cyclophilin, putative
Plasmodium yoelii PY00017   peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative
Saccharomyces cerevisiae YPL064C   putative peptidylprolyl isomerase CWC27
Schistosoma japonicum Sjp_0084620   ko:K01802 peptidylprolyl isomerase [EC5.2.1.8], putative
Schistosoma mansoni Smp_084080   peptidyl-prolyl cis-trans isomerase (cyclophilin)
Schmidtea mediterranea mk4.014986.00   Peptidyl-prolyl cis-trans isomerase CWC27 homolog
Schmidtea mediterranea mk4.004419.06   Peptidyl-prolyl cis-trans isomerase CWC27 homolog
Toxoplasma gondii TGME49_241830   peptidyl-prolyl cis-trans isomerase
Theileria parva TP02_0598   cyclophilin, putative

Essentiality

PF3D7_1423200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1020200 Plasmodium berghei Dispensable plasmo
TGME49_241830 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1423200 (Plasmodium falciparum), peptidyl-prolyl cis-trans isomerase
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