pI: 8.5752 |
Length (AA): 328 |
MW (Da): 37039 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 376 | 1w3b (A) | 71 | 398 | 17.00 | 0 | 1 | 1.1 | 0.07 |
260 | 375 | 1ihg (A) | 223 | 353 | 17.00 | 0.000028 | 0.95 | 0.55 | -1.4 |
4 | 325 | 1w3b (A) | 85 | 398 | 11.00 | 0.021 | 0.11 | 1.00141 | 0.64 |
63 | 159 | 1i2h (A) | 1035 | 1136 | 34.00 | 0.66 | 0.77 | 0.367732 | 1.04 |
142 | 311 | 3ulq (A) | 117 | 295 | 14.00 | 0 | 1 | 0.685893 | -0.22 |
203 | 270 | 5djs (A) | 3 | 70 | 22.00 | 0 | 0.78 | 0.611917 | -1.24 |
206 | 270 | 1fch (A) | 295 | 359 | 17.00 | 0 | 0.61 | 0.510771 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | VEG Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_129394)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_23330 | TPR Domain containing protein |
Caenorhabditis elegans | CELE_ZK328.7 | Protein ZK328.7, isoform B |
Echinococcus granulosus | EgrG_000952700 | tetratricopeptide repeat protein 21b |
Echinococcus multilocularis | EmuJ_000952700 | titin |
Homo sapiens | ENSG00000123607 | tetratricopeptide repeat domain 21B |
Homo sapiens | ENSG00000168026 | tetratricopeptide repeat domain 21A |
Leishmania braziliensis | LbrM.04.0600 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_040540.1 | TPR repeat/Tetratricopeptide repeat, putative |
Leishmania infantum | LinJ.04.0540 | hypothetical protein, conserved |
Leishmania major | LmjF.04.0550 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.04.0550 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04046 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04047 | hypothetical protein |
Mus musculus | ENSMUSG00000032514 | tetratricopeptide repeat domain 21A |
Mus musculus | ENSMUSG00000034848 | tetratricopeptide repeat domain 21B |
Neospora caninum | NCLIV_017520 | TPR Domain containing protein, putative |
Onchocerca volvulus | OVOC9174 | Tetratricopeptide repeat protein 21 homolog |
Schistosoma japonicum | Sjp_0118160 | Tetratricopeptide repeat protein 21B, putative |
Schistosoma japonicum | Sjp_0089470 | Tetratricopeptide repeat protein 21B, putative |
Schistosoma japonicum | Sjp_0089460 | Tetratricopeptide repeat protein 21B, putative |
Schistosoma mansoni | Smp_179920 | hypothetical protein |
Schmidtea mediterranea | mk4.004137.06 | |
Schmidtea mediterranea | mk4.004137.05 | Tetratricopeptide repeat protein 21 homolog |
Schmidtea mediterranea | mk4.004137.02 | |
Trypanosoma brucei gambiense | Tbg972.9.4220 | tetratricopeptide repeat protein, predicted |
Trypanosoma brucei | Tb927.9.7720 | predicted tetratricopeptide repeat protein |
Trypanosoma congolense | TcIL3000_9_2650 | predicted tetratricopeptide repeat protein |
Trypanosoma cruzi | TcCLB.504033.180 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508199.90 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_242360 | tetratricopeptide repeat-containing protein |
Toxoplasma gondii | TGME49_242350 | tetratricopeptide repeat-containing protein |
Trichomonas vaginalis | TVAG_491240 | TPR repeat-containing protein ZK328.7, putative |
Trichomonas vaginalis | TVAG_006830 | TPR repeat-containing protein ZK328.7, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.5670 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.5670 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.5670 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.5670 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_242350 this record | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_242360 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.