Detailed view for TGME49_217050

Basic information

TDR Targets ID: 263830
Toxoplasma gondii, ADA2-A transcriptional co-activator SAGA component
Source Database / ID:  ToxoDB 

pI: 6.6108 | Length (AA): 1203 | MW (Da): 126320 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00249   Myb-like DNA-binding domain
PF00569   Zinc finger, ZZ type

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0003677   DNA binding  
GO:0045449   regulation of transcription  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
426 477 1guu (A) 43 89 26.00 0.00000059 0.39 0.42 -1.84
824 920 2aqe (A) 1 90 32.00 0 0.83 0.48 -0.64
587 644 1x41 (A) 8 59 50.00 0 0.74 0.574113 -1.2
589 638 1x41 (A) 10 54 53.00 0.0000022 0.98 0.709463 -1.58
968 1076 2cuj (A) 3 100 32.00 0.00028 0.99 0.391507 0
996 1078 2elj (A) 2 85 22.00 0 0.81 0.390894 -0.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Hehl AB Fritz HM Sibley/Greg
Show/Hide expression data references
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_127420)

Species Accession Gene Product
Arabidopsis thaliana AT3G07740   transcriptional adapter ADA2a
Arabidopsis thaliana AT4G16420   transcriptional adapter ADA2b
Babesia bovis BBOV_IV001060   conserved hypothetical protein
Babesia bovis BBOV_IV011130   ADA2-like protein, putative
Candida albicans CaO19.2331   transcription factor
Candida albicans CaO19.9867   transcription factor
Cryptosporidium hominis Chro.40107   ADA2-like protein
Cryptosporidium parvum cgd4_880   ADA2 ortholog with a ZZ finger, SANT domain and a SWIRM domain
Dictyostelium discoideum DDB_G0280079   SWIRM domain-containing protein
Drosophila melanogaster Dmel_CG43663   transcriptional Adaptor 2a
Drosophila melanogaster Dmel_CG9638   transcriptional Adaptor 2b
Echinococcus granulosus EgrG_000859000   Transcriptional adapter 2B
Echinococcus granulosus EgrG_000243100   transcriptional adapter 2 beta
Entamoeba histolytica EHI_142140   transcriptional adaptor ADA2, putative
Echinococcus multilocularis EmuJ_000243100   transcriptional adapter 2 beta
Echinococcus multilocularis EmuJ_000859000   Transcriptional adapter 2B
Homo sapiens ENSG00000276234   transcriptional adaptor 2A
Homo sapiens ENSG00000173011   transcriptional adaptor 2B
Mus musculus ENSMUSG00000029196   transcriptional adaptor 2B
Mus musculus ENSMUSG00000018651   transcriptional adaptor 2A
Neospora caninum NCLIV_059260   hypothetical protein
Oryza sativa 4334126   Os03g0750800
Plasmodium berghei PBANKA_1213000   transcriptional coactivator ADA2, putative
Plasmodium falciparum PF3D7_1014600   transcriptional coactivator ADA2
Plasmodium knowlesi PKNH_0814700   transcriptional coactivator ADA2, putative
Plasmodium vivax PVX_094945   transcriptional coactivator ADA2, putative
Plasmodium yoelii PY03808   ADA2-like protein
Saccharomyces cerevisiae YDR448W   Ada2p
Schistosoma japonicum Sjp_0028600   ko:K00653 histone acetyltransferase [EC2.3.1.48], putative
Schistosoma mansoni Smp_004040   transcriptional adaptor 2 (ada2)-related
Schmidtea mediterranea mk4.000259.05   Transcriptional adapter 2-beta
Toxoplasma gondii TGME49_217050   ADA2-A transcriptional co-activator SAGA component
Theileria parva TP01_0779   transcriptional adapter 2 protein, putative
Theileria parva TP01_0128   hypothetical protein
Trichomonas vaginalis TVAG_383990   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_004230   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_107380   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_140100   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_486940   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_127940   transcriptional adaptor, putative
Trichomonas vaginalis TVAG_164270   transcriptional adaptor, putative

Essentiality

TGME49_217050 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1213000 Plasmodium berghei Essential plasmo
TGME49_217050 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TGME49_217050 (Toxoplasma gondii), ADA2-A transcriptional co-activator SAGA component
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