pI: 9.4779 |
Length (AA): 2382 |
MW (Da): 275949 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 432 | 5wtk (A) | 749 | 1329 | 29.00 | 0.0000063 | 1 | 0.0210639 | 2.19 |
1416 | 1467 | 2elk (A) | 11 | 58 | 46.00 | 0.0011 | 1 | 0.54593 | -0.57 |
1416 | 1465 | 1x41 (A) | 10 | 54 | 47.00 | 0.0025 | 0.87 | 0.560091 | -1.05 |
2043 | 2153 | 3ult (A) | 6 | 113 | 30.00 | 0.001 | 0.05 | 0.628699 | -3.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | 16 hs Trophozoite. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | 4 hs Ring, Erthyrocytic stages, Female gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Ookinete, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Gametocyte, 22 hs Schizont. | Otto TD |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Ortholog group members (OG5_127420)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G07740 | transcriptional adapter ADA2a |
Arabidopsis thaliana | AT4G16420 | transcriptional adapter ADA2b |
Babesia bovis | BBOV_IV001060 | conserved hypothetical protein |
Babesia bovis | BBOV_IV011130 | ADA2-like protein, putative |
Candida albicans | CaO19.2331 | transcription factor |
Candida albicans | CaO19.9867 | transcription factor |
Cryptosporidium hominis | Chro.40107 | ADA2-like protein |
Cryptosporidium parvum | cgd4_880 | ADA2 ortholog with a ZZ finger, SANT domain and a SWIRM domain |
Dictyostelium discoideum | DDB_G0280079 | SWIRM domain-containing protein |
Drosophila melanogaster | Dmel_CG43663 | transcriptional Adaptor 2a |
Drosophila melanogaster | Dmel_CG9638 | transcriptional Adaptor 2b |
Echinococcus granulosus | EgrG_000859000 | Transcriptional adapter 2B |
Echinococcus granulosus | EgrG_000243100 | transcriptional adapter 2 beta |
Entamoeba histolytica | EHI_142140 | transcriptional adaptor ADA2, putative |
Echinococcus multilocularis | EmuJ_000243100 | transcriptional adapter 2 beta |
Echinococcus multilocularis | EmuJ_000859000 | Transcriptional adapter 2B |
Homo sapiens | ENSG00000276234 | transcriptional adaptor 2A |
Homo sapiens | ENSG00000173011 | transcriptional adaptor 2B |
Mus musculus | ENSMUSG00000029196 | transcriptional adaptor 2B |
Mus musculus | ENSMUSG00000018651 | transcriptional adaptor 2A |
Neospora caninum | NCLIV_059260 | hypothetical protein |
Oryza sativa | 4334126 | Os03g0750800 |
Plasmodium berghei | PBANKA_1213000 | transcriptional coactivator ADA2, putative |
Plasmodium falciparum | PF3D7_1014600 | transcriptional coactivator ADA2 |
Plasmodium knowlesi | PKNH_0814700 | transcriptional coactivator ADA2, putative |
Plasmodium vivax | PVX_094945 | transcriptional coactivator ADA2, putative |
Plasmodium yoelii | PY03808 | ADA2-like protein |
Saccharomyces cerevisiae | YDR448W | Ada2p |
Schistosoma japonicum | Sjp_0028600 | ko:K00653 histone acetyltransferase [EC2.3.1.48], putative |
Schistosoma mansoni | Smp_004040 | transcriptional adaptor 2 (ada2)-related |
Schmidtea mediterranea | mk4.000259.05 | Transcriptional adapter 2-beta |
Toxoplasma gondii | TGME49_217050 | ADA2-A transcriptional co-activator SAGA component |
Theileria parva | TP01_0779 | transcriptional adapter 2 protein, putative |
Theileria parva | TP01_0128 | hypothetical protein |
Trichomonas vaginalis | TVAG_383990 | transcriptional adaptor, putative |
Trichomonas vaginalis | TVAG_004230 | transcriptional adaptor, putative |
Trichomonas vaginalis | TVAG_107380 | transcriptional adaptor, putative |
Trichomonas vaginalis | TVAG_140100 | transcriptional adaptor, putative |
Trichomonas vaginalis | TVAG_486940 | transcriptional adaptor, putative |
Trichomonas vaginalis | TVAG_127940 | transcriptional adaptor, putative |
Trichomonas vaginalis | TVAG_164270 | transcriptional adaptor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1213000 this record | Plasmodium berghei | Essential | plasmo |
TGME49_217050 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.