pI: 4.8218 |
Length (AA): 898 |
MW (Da): 97379 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 12 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 281 | 1aui (A) | 51 | 340 | 39.00 | 0 | 1 | 1.47 | -1.96 |
2 | 283 | 1s70 (A) | 24 | 304 | 43.00 | 0 | 1 | 1.59 | -1.9 |
8 | 295 | 1s95 (A) | 205 | 498 | 36.00 | 0 | 1 | 1.5 | -1.73 |
195 | 390 | 5t58 (N) | 11 | 215 | 11.00 | 0 | 0 | 0.267063 | -0.29 |
571 | 898 | 5b8i (A) | 34 | 361 | 36.00 | 0.00000000011 | 1 | 0.726056 | -0.75 |
572 | 869 | 1aui (A) | 18 | 326 | 39.00 | 0 | 1 | 0.844649 | -1.23 |
585 | 898 | 3fga (C) | 2 | 309 | 54.00 | 0 | 1 | 1.01147 | -1 |
585 | 773 | 2z72 (A) | 28 | 229 | 29.00 | 0.0092 | 0.94 | 0.256268 | 0.99 |
595 | 741 | 4iyp (C) | 9 | 153 | 59.00 | 0 | 1 | 0.599497 | -0.25 |
611 | 885 | 1s70 (A) | 30 | 306 | 44.00 | 0 | 1 | 0.900036 | -1.18 |
631 | 763 | 4j6o (A) | 173 | 331 | 35.00 | 0.0068 | 0.64 | 0.218907 | 0.44 |
635 | 825 | 1g5b (A) | 10 | 201 | 20.00 | 0 | 0.27 | 0.119495 | 0.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Oocyst, ME49 Bradyzoite. | Fritz HM Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Sibley/Greg | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_129276)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G50370 | phytochrome-associated serine/threonine protein phosphatase 1 |
Arabidopsis thaliana | AT3G19980 | phytochrome-associated serine/threonine protein phosphatase 3 |
Brugia malayi | Bm1_03950 | Serine/threonine protein phosphatase C34C12.3 in chromosomeIII |
Candida albicans | CaO19.12667 | calcineurin-like phosphoesterase similar to S. cerevisiae SIT4 (YDL047W) type 2A-related protein phosphatase |
Candida albicans | CaO19.5200 | calcineurin-like phosphoesterase similar to S. cerevisiae SIT4 (YDL047W) type 2A-related protein phosphatase |
Caenorhabditis elegans | CELE_C34C12.3 | Protein PPH-6 |
Dictyostelium discoideum | DDB_G0272118 | protein phosphatase 6 catalytic subunit |
Drosophila melanogaster | Dmel_CG12217 | Protein phosphatase V |
Echinococcus granulosus | EgrG_000763800 | serine:threonine protein phosphatase 6 catalytic |
Entamoeba histolytica | EHI_147500 | serine/threonine-protein phosphatase ppe1, putative |
Echinococcus multilocularis | EmuJ_000763800 | serine:threonine protein phosphatase 6 catalytic |
Homo sapiens | ENSG00000119414 | protein phosphatase 6, catalytic subunit |
Mus musculus | 67857 | protein phosphatase 6, catalytic subunit |
Neospora caninum | NCLIV_069860 | Serine/threonine protein phosphatase (EC 3.1.3.16), related |
Oryza sativa | 4325641 | Os01g0691700 |
Plasmodium berghei | PBANKA_0412100 | serine/threonine protein phosphatase 6 |
Plasmodium falciparum | PF3D7_0314400 | serine/threonine protein phosphatase 6, putative |
Plasmodium knowlesi | PKNH_0827700 | serine/threonine protein phosphatase 6, putative |
Plasmodium vivax | PVX_119815 | serine/threonine protein phosphatase 6, putative |
Plasmodium yoelii | PY02284 | Serine/threonine protein phosphatase |
Saccharomyces cerevisiae | YDL047W | type 2A-related serine/threonine-protein phosphatase SIT4 |
Schistosoma japonicum | Sjp_0028950 | Serine/threonine-protein phosphatase 6, putative |
Schistosoma mansoni | Smp_023150 | serine/threonine specific protein phosphatase |
Schmidtea mediterranea | mk4.009019.00 | Serine/threonine-protein phosphatase PP2A |
Schmidtea mediterranea | mk4.003114.00 | Serine/threonine-protein phosphatase 6 catalytic subunit |
Schmidtea mediterranea | mk4.002937.03 | Serine/threonine-protein phosphatase 6 catalytic subunit |
Toxoplasma gondii | TGME49_301010 | serine/threonine protein phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_301010 this record | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3
6 literature references were collected for this gene.