Detailed view for PVX_088235

Basic information

TDR Targets ID: 265558
Plasmodium vivax, ferlin, putative
Source Database / ID:  PlasmoDB 

pI: 6.0466 | Length (AA): 1696 | MW (Da): 190800 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
205 326 1gmi (A) 3 131 11.00 0.000000031 0.11 0.12 -0.69
646 771 1rsy () 143 264 21.00 0.000000000033 0.11 0.22 -0.22
1314 1464 1wfj (A) 2 130 15.00 0.00000000081 0.89 0.1 0.15
1470 1601 1w15 (A) 288 420 23.00 0 0.83 0.34 -0.33
7 129 1tjx (A) 285 403 27.00 0 0.76 0.225124 0.52
25 127 5cch (F) 295 401 35.00 0.12 0.63 0.160531 1.13
234 327 4rj9 (A) 28 128 33.00 0.89 0.47 0.122225 0.6
276 415 4url (A) 95 253 28.00 0.41 0.57 0.189347 1.4
649 776 2enp (A) 16 146 16.00 0 0.24 0.0370717 0.61
658 787 4icw (A) 7 132 18.00 0 0.23 0.241251 -0.15
986 1019 3bog (C) 3 69 56.00 0.015 0.01 0.430847 1.4
1474 1577 2b3r (A) 1385 1489 17.00 0 0.95 0.264921 -0.09
1493 1601 1tjx (A) 296 405 16.00 0.5 0.07 0.104669 0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 18 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_137859)

Species Accession Gene Product
Babesia bovis BBOV_II005690   C2 domain containing protein
Cryptosporidium hominis Chro.80338   hypothetical protein
Cryptosporidium parvum cgd8_2910   ferlin-like type II membrane associated protein with 5 C2 domains, transmembrane domain or GPI anchor at C-terminus
Neospora caninum NCLIV_053770   C2 domain-containing protein, putative
Plasmodium berghei PBANKA_1224400   ferlin, putative
Plasmodium falciparum PF3D7_0806300   ferlin, putative
Plasmodium knowlesi PKNH_0112600   ferlin, putative
Plasmodium vivax PVX_088235   ferlin, putative
Plasmodium yoelii PY04695   hypothetical protein
Toxoplasma gondii TGME49_309420   ferlin family protein
Theileria parva TP02_0522   hypothetical protein

Essentiality

PVX_088235 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1224400 Plasmodium berghei Essential plasmo
TGME49_309420 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0107 0.5 0.5
0.0125 0.3893 1
0.0109 0.4866 0.5
0.0058 0.5 0.5
0.0071 0.2549 0
0.0018 0.5 0.5
0.005 0.2612 0
0.0072 0.2639 0
0.0057 0.3491 0.5
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_088235 (Plasmodium vivax), ferlin, putative
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