Detailed view for PF3D7_1435000

Basic information

TDR Targets ID: 2662
Plasmodium falciparum, cytochrome c oxidase assembly protein COX15, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.4326 | Length (AA): 430 | MW (Da): 50425 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02628   Cytochrome oxidase assembly protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0006784   heme a biosynthetic process  
GO:0003674   molecular_function  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0055114   oxidation reduction  
GO:0008535   respiratory chain complex IV assembly  
GO:0006461   protein complex assembly  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 32 hs, merozoite, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late ring, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, sporozoite, early ring, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128426)

Species Accession Gene Product
Arabidopsis thaliana AT5G56090   cytochrome c oxidase assembly protein COX15
Babesia bovis BBOV_III002290   cytochrome c oxidase assembly protein, putative
Brugia malayi Bm1_07665   Cytochrome oxidase assembly protein
Candida albicans CaO19.3656   cytochrome oxidase assembly
Candida albicans CaO19.11140   cytochrome oxidase assembly
Caenorhabditis elegans CELE_T06D8.5   Protein T06D8.5
Dictyostelium discoideum DDB_G0281549   cytochrome c oxidase assembly protein
Drosophila melanogaster Dmel_CG3803   CG3803 gene product from transcript CG3803-RA
Echinococcus granulosus EgrG_000451100   cytochrome c oxidase subunit XV assembly
Echinococcus multilocularis EmuJ_000451100   cytochrome c oxidase subunit XV assembly
Homo sapiens 1355   cytochrome c oxidase assembly homolog 15 (yeast)
Leishmania braziliensis LbrM.28.2890   cytochrome oxidase assembly protein-like protein
Leishmania donovani LdBPK_282880.1   cytochrome oxidase assembly protein-like protein
Leishmania infantum LinJ.28.2880   cytochrome oxidase assembly protein-like protein
Leishmania major LmjF.28.2680   cytochrome oxidase assembly protein-like protein
Leishmania mexicana LmxM.28.2680   cytochrome oxidase assembly protein-like protein
Loa Loa (eye worm) LOAG_08709   hypothetical protein
Mus musculus ENSMUSG00000040018   cytochrome c oxidase assembly protein 15
Neospora caninum NCLIV_045250   cytochrome C oxidase assembly factor COX15, putative
Oryza sativa 4345926   Os08g0496000
Plasmodium berghei PBANKA_1009800   cytochrome c oxidase assembly protein COX15, putative
Plasmodium falciparum PF3D7_1435000   cytochrome c oxidase assembly protein COX15, putative
Plasmodium knowlesi PKNH_0421600   cytochrome c oxidase assembly protein COX15, putative
Plasmodium vivax PVX_084785   cytochrome c oxidase assembly protein, putative
Plasmodium yoelii PY02555   cytochrome c oxidase assembly protein
Saccharomyces cerevisiae YER141W   Cox15p
Schistosoma japonicum Sjp_0302460   ko:K02259 cytochrome c oxidase subunit XV assembly protein, putative
Schistosoma mansoni Smp_147510   cytochrome C oxidase assembly protein cox15
Schmidtea mediterranea mk4.002473.04   Cytochrome c oxidase assembly protein COX15 homolog
Schmidtea mediterranea mk4.012403.00   Cytochrome c oxidase assembly protein COX15 homolog
Trypanosoma brucei gambiense Tbg972.11.13410   cytochrome oxidase assembly protein, putative
Trypanosoma brucei Tb927.11.11950   cytochrome oxidase assembly protein, putative
Trypanosoma congolense TcIL3000.11.12610   cytochrome oxidase assembly protein, putative
Trypanosoma cruzi TcCLB.511211.70   cytochrome c oxidase assembly protein
Toxoplasma gondii TGME49_228180   cytochrome C oxidase assembly factor COX15, putative
Theileria parva TP03_0594   cytochrome c oxidase assembly protein, putative
Wolbachia endosymbiont of Brugia malayi Wbm0456   hypothetical protein

Essentiality

PF3D7_1435000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.3780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.3780 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.3780 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T06D8.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_T06D8.5 Caenorhabditis elegans slow growth wormbase
PBANKA_1009800 Plasmodium berghei Essential plasmo
TGME49_228180 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Cytochrome Oxidase (1.9.3.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

39 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1435000 (Plasmodium falciparum), cytochrome c oxidase assembly protein COX15, putative
Title for this comment
Comment