pI: 10.3046 |
Length (AA): 135 |
MW (Da): 16226 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
79 | 111 | 1srk (A) | 2 | 34 | 18.00 | 0 | 0.19 | 0.4 | -0.08 |
68 | 106 | 4f6m (A) | 533 | 571 | 26.00 | 0.039 | 0.13 | 0.603789 | -0.5 |
70 | 134 | 1zr9 (A) | 28 | 91 | 42.00 | 0 | 0.74 | 0.909382 | 0.48 |
84 | 123 | 2ee8 (A) | 17 | 47 | 32.00 | 0.17 | 0.06 | 0.249196 | 0.75 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 24 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 40 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_128822)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G36930 | C2H2-type zinc finger-containing protein |
Babesia bovis | BBOV_II001440 | hypothetical protein |
Brugia malayi | Bm1_39315 | Zinc finger, C2H2 type family protein |
Candida albicans | CaO19.10451 | similar to protein that copurifies with nuclear pore complex |
Candida albicans | CaO19.2934 | similar to protein that copurifies with nuclear pore complex |
Caenorhabditis elegans | CELE_Y56A3A.18 | Protein Y56A3A.18 |
Dictyostelium discoideum | DDB_G0275351 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3224 | CG3224 gene product from transcript CG3224-RA |
Echinococcus granulosus | EgrG_000777500 | zinc finger C2H2 type |
Entamoeba histolytica | EHI_017720 | zinc finger protein, putative |
Echinococcus multilocularis | EmuJ_000777500 | zinc finger, C2H2 type |
Giardia lamblia | GL50803_16877 | Zinc finger domain |
Homo sapiens | 51042 | zinc finger protein 593 |
Loa Loa (eye worm) | LOAG_11000 | zinc finger protein |
Mus musculus | ENSMUSG00000028840 | zinc finger protein 593 |
Neospora caninum | NCLIV_046700 | zinc finger protein, putative |
Oryza sativa | 4346346 | Os08g0564500 |
Onchocerca volvulus | OVOC4965 | Zinc finger protein 593 homolog |
Plasmodium berghei | PBANKA_1327800 | zinc finger protein, putative |
Plasmodium falciparum | PF3D7_1464400 | zinc finger protein, putative |
Plasmodium knowlesi | PKNH_1217100 | zinc finger protein, putative |
Plasmodium vivax | PVX_117245 | hypothetical protein, conserved |
Saccharomyces cerevisiae | YLR074C | Bud20p |
Schistosoma japonicum | Sjp_0054090 | Bud site selection protein 20, putative |
Schistosoma mansoni | Smp_070130 | zinc finger protein |
Schmidtea mediterranea | mk4.000134.13 | Zinc finger protein 593 |
Toxoplasma gondii | TGME49_226240 | bud site selection protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y56A3A.18 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y56A3A.18 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y56A3A.18 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_226240 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.