Detailed view for PF3D7_1438000

Basic information

TDR Targets ID: 2691
Plasmodium falciparum, eukaryotic translation initiation factor eIF2A, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4 | Length (AA): 661 | MW (Da): 76833 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08662   Eukaryotic translation initiation factor eIF2A

Gene Ontology

Mouse over links to read term descriptions.
GO:0003743   translation initiation factor activity  
GO:0006413   translational initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
299 562 1crz (A) 160 407 11.00 0.00000016 0.63 0.49 -0.12
10 189 4u5a (C) 47 239 17.00 0.18 0.01 0.420315 -0.54
230 566 4nox (A) 249 638 17.00 0 1 0.563834 0.49
254 564 3wj9 (A) 102 410 31.00 0 1 0.721499 0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128129)

Species Accession Gene Product
Arabidopsis thaliana AT1G73180   eukaryotic translation initiation factor eIF2A-like protein
Babesia bovis BBOV_IV009900   conserved hypothetical protein
Brugia malayi Bm1_53410   Hypothetical 71.3 kDa protein in SCM4-MUP1 intergenic region
Brugia malayi Bm1_02635   LOC398445 protein
Candida albicans CaO19.2930   signaling protein,mating, glycosylation
Candida albicans CaO19.10447   signaling protein,mating, glycosylation
Caenorhabditis elegans CELE_E04D5.1   Protein E04D5.1, isoform B
Cryptosporidium hominis Chro.70110   hypothetical protein
Cryptosporidium parvum cgd7_880   eIF-3A like translation initiation factor that has a WD40 repeat-containing beta propeller
Dictyostelium discoideum DDB_G0284267   eukaryotic translation initiation factor 2A
Drosophila melanogaster Dmel_CG7414   CG7414 gene product from transcript CG7414-RC
Echinococcus granulosus EgrG_000525500   eukaryotic translation initiation factor 2A
Entamoeba histolytica EHI_200070   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000525500   eukaryotic translation initiation factor 2A
Homo sapiens 83939   eukaryotic translation initiation factor 2A, 65kDa
Leishmania braziliensis LbrM.16.0680   hypothetical protein, conserved
Leishmania donovani LdBPK_160690.1   eukaryotic translation initiation factor eIF2A, putative
Leishmania infantum LinJ.16.0690   hypothetical protein, conserved
Leishmania major LmjF.16.0690   hypothetical protein, conserved
Leishmania mexicana LmxM.16.0690   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04420   hypothetical protein
Loa Loa (eye worm) LOAG_04419   hypothetical protein
Mus musculus ENSMUSG00000027810   eukaryotic translation initiation factor 2A
Neospora caninum NCLIV_027770   hypothetical protein
Oryza sativa 4329922   Os02g0606100
Onchocerca volvulus OVOC1836   Eukaryotic translation initiation factor 2A homolog
Plasmodium berghei PBANKA_0610800   eukaryotic initiation factor 2a, putative
Plasmodium falciparum PF3D7_1438000   eukaryotic translation initiation factor eIF2A, putative
Plasmodium knowlesi PKNH_0424700   eukaryotic initiation factor 2a, putative
Plasmodium knowlesi PKNH_0838000   eukaryotic translation initiation factor eIF2A, putative
Plasmodium vivax PVX_084645   hypothetical protein, conserved
Plasmodium yoelii PY02477   unknown protein
Saccharomyces cerevisiae YGR054W   hypothetical protein
Schistosoma japonicum Sjp_0204810   Eukaryotic translation initiation factor 2A, putative
Schistosoma mansoni Smp_175840   nuclease-related
Schmidtea mediterranea mk4.007504.00  
Trypanosoma brucei gambiense Tbg972.5.4830   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.3450   eukaryotic translation initiation factor eIF2A, putative
Trypanosoma congolense TcIL3000_5_3910   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511647.60   eukaryotic translation initiation factor eIF2A, putative
Trypanosoma cruzi TcCLB.503529.20   eukaryotic translation initiation factor eIF2A, putative
Toxoplasma gondii TGME49_258740   eukaryotic initiation factor-2A, putative
Theileria parva TP01_0707   hypothetical protein
Trichomonas vaginalis TVAG_139050   conserved hypothetical protein

Essentiality

PF3D7_1438000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.3450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.3450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.3450 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3450 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_E04D5.1 Caenorhabditis elegans embryonic lethal wormbase
TGME49_258740 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1438000 (Plasmodium falciparum), eukaryotic translation initiation factor eIF2A, putative
Title for this comment
Comment