Detailed view for PF3D7_1441400

Basic information

TDR Targets ID: 2724
Plasmodium falciparum, FACT complex subunit SSRP1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.3135 | Length (AA): 506 | MW (Da): 58787 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03531   Structure-specific recognition protein (SSRP1)
PF08512   Histone chaperone Rttp106-like
PF17292   POB3-like N-terminal PH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0005634   nucleus  
GO:0003697   single-stranded DNA binding  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
209 441 2gcl (A) 237 474 33.00 0 1 1.05 -2.11
204 440 4pq0 (A) 232 473 33.00 0 1 0.978579 -1.38
212 441 4ifs (A) 197 427 36.00 0 1 1.05435 -1.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, late schizont, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_127386)

Species Accession Gene Product
Arabidopsis thaliana AT3G28730   FACT complex subunit SSRP1
Babesia bovis BBOV_III003170   structure specific recognition protein, putative
Brugia malayi Bm1_18530   structure-specific recognition protein 1
Candida albicans CaO19.9133   similar to S. cerevisiae POB3 (YML069W) DNA Polymerase binding protein and RNA Pol II transcriptional elongation regulator invol
Candida albicans CaO19.1560   similar to S. cerevisiaePOB3 (YML069W) DNA Polymerase binding protein and RNA Pol II transcriptional elongation regulator involv
Caenorhabditis elegans CELE_C32F10.5   Protein HMG-3
Caenorhabditis elegans CELE_T20B12.8   Protein HMG-4
Cryptosporidium hominis Chro.70588   structure specific recognition protein
Cryptosporidium parvum cgd7_5280   structure-specific recognition protein 1 (SSRP1) (recombination signal sequence recognition protein)
Dictyostelium discoideum DDB_G0290331   FACT complex subunit SSRP1
Drosophila melanogaster Dmel_CG4817   Structure specific recognition protein
Echinococcus granulosus EgrG_000894800   fact complex subunit ssrp1
Entamoeba histolytica EHI_082500   structure specific recognition protein, putative
Echinococcus multilocularis EmuJ_000894800   fact complex subunit ssrp1
Homo sapiens ENSG00000149136   structure specific recognition protein 1
Leishmania braziliensis LbrM.32.0280   hypothetical protein, conserved
Leishmania donovani LdBPK_320220.1   Histone chaperone Rttp106-like, putative
Leishmania infantum LinJ.32.0220   hypothetical protein, conserved
Leishmania major LmjF.32.0210   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0210   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04347   structure-specific recognition protein 1
Mus musculus ENSMUSG00000027067   structure specific recognition protein 1
Neospora caninum NCLIV_026040   structure specific recognition protein I, putative
Oryza sativa 4325652   Os01g0184900
Oryza sativa 4337994   Os05g0182600
Onchocerca volvulus OVOC7702   FACT complex subunit SSRP1 homolog
Plasmodium berghei PBANKA_1305300   FACT complex subunit SSRP1, putative
Plasmodium falciparum PF3D7_1441400   FACT complex subunit SSRP1, putative
Plasmodium knowlesi PKNH_1240900   FACT complex subunit SSRP1, putative
Plasmodium vivax PVX_118420   FACT complex subunit SSRP1, putative
Plasmodium yoelii PY06541   structure-specific recognition protein 1
Plasmodium yoelii PY06012   putative structure specific recognition protein
Saccharomyces cerevisiae YML069W   FACT complex subunit POB3
Schistosoma japonicum Sjp_0035580   ko:K09272 structure-specific recognition protein 1, putative
Schistosoma mansoni Smp_148930   structure specific recognition protein
Trypanosoma brucei gambiense Tbg972.10.17490   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.14390   Histone chaperone Rttp106-like, putative
Trypanosoma congolense TcIL3000_10_12240   Histone chaperone Rttp106-like, putative
Trypanosoma cruzi TcCLB.511283.220   Histone chaperone Rttp106-like, putative
Toxoplasma gondii TGME49_261460   transcriptional elongation factor FACT80
Theileria parva TP04_0129   structure specific recognition protein, putative
Trichomonas vaginalis TVAG_192570   structure-specific recognition protein, putative

Essentiality

PF3D7_1441400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14390 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.14390 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14390 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14390 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C32F10.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C32F10.5 Caenorhabditis elegans larval arrest wormbase
CELE_C32F10.5 Caenorhabditis elegans larval lethal wormbase
CELE_C32F10.5 Caenorhabditis elegans slow growth wormbase
CELE_C32F10.5 Caenorhabditis elegans sterile wormbase
CELE_T20B12.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_T20B12.8 Caenorhabditis elegans larval arrest wormbase
CELE_T20B12.8 Caenorhabditis elegans larval lethal wormbase
CELE_T20B12.8 Caenorhabditis elegans slow growth wormbase
YML069W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1305300 Plasmodium berghei Essential plasmo
TGME49_261460 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1441400 (Plasmodium falciparum), FACT complex subunit SSRP1, putative
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