pI: 5.8446 |
Length (AA): 1275 |
MW (Da): 149319 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 21 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 247 | 1npe (A) | 913 | 1162 | 6.00 | 0 | 0.31 | -0.07 | -0.55 |
792 | 1134 | 1p22 (A) | 199 | 545 | 17.00 | 0 | 1 | 0.43 | -0.1 |
77 | 191 | 4wjs (A) | 157 | 268 | 29.00 | 0.00064 | 1 | 0.494196 | -0.63 |
106 | 198 | 4u1e (I) | 7 | 89 | 34.00 | 0.0012 | 0.97 | 0.421941 | -0.41 |
581 | 1010 | 2ymu (A) | 110 | 542 | 21.00 | 0.00034 | 1 | 0.397255 | 1.21 |
848 | 1113 | 4wju (A) | 142 | 406 | 20.00 | 0 | 0.78 | 0.302727 | 0.66 |
855 | 1004 | 3ow8 (A) | 153 | 302 | 27.00 | 0 | 0.71 | 0.468747 | -0.38 |
5 | 112 | 4buj (C) | 221 | 336 | 19.00 | 0.042 | 0.42 | 0.212912 | 0 |
13 | 191 | 3v7d (B) | 468 | 660 | 28.00 | 0.00023 | 0.92 | 0.327608 | 0.14 |
24 | 247 | 4yvd (A) | 209 | 423 | 21.00 | 0.000047 | 1 | 0.262655 | 0.42 |
30 | 231 | 4lg9 (A) | 279 | 468 | 26.00 | 0.0000052 | 1 | 0.425521 | 0.12 |
84 | 198 | 3vl1 (A) | 111 | 215 | 33.00 | 0.00032 | 0.83 | 0.404764 | -0.02 |
851 | 1035 | 4j73 (A) | 89 | 272 | 21.00 | 0.1 | 0.97 | 0.341281 | 0.4 |
859 | 1064 | 3sfz (A) | 615 | 828 | 22.00 | 0.000011 | 0.92 | 0.414636 | 0.18 |
859 | 1019 | 2ymu (A) | 385 | 542 | 23.00 | 0.00079 | 0.96 | 0.467589 | -0.36 |
862 | 1020 | 4j0w (A) | 149 | 320 | 26.00 | 0.00055 | 0.83 | 0.392032 | 0.15 |
864 | 1014 | 3odt (A) | 103 | 248 | 29.00 | 0.057 | 1 | 0.465801 | -0.08 |
893 | 1026 | 4ery (A) | 37 | 172 | 30.00 | 0.00000077 | 0.79 | 0.458561 | 0.05 |
899 | 1012 | 3frx (A) | 63 | 181 | 27.00 | 0.012 | 0.61 | 0.404985 | 0.05 |
970 | 1097 | 1erj (A) | 470 | 605 | 10.00 | 0.0000065 | 0.06 | 0.0894885 | 0.93 |
983 | 1215 | 2aq5 (A) | 79 | 317 | 13.00 | 0.0081 | 0.1 | 0.112264 | 1.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 32 hs, Oocyst, Sporozoite, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, Male Gametocyte. | Otto TD PlasmoDB Lasonder E |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127984)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G21540 | transducin/WD40 domain-containing protein |
Babesia bovis | BBOV_III011180 | WD domain, G-beta repeat containing protein |
Brugia malayi | Bm1_05345 | WD-repeat protein 3 |
Candida albicans | CaO19.5106 | DOM34-interacting protein |
Candida albicans | CaO19.12572 | DOM34-interacting protein |
Caenorhabditis elegans | CELE_F13H8.2 | Protein F13H8.2 |
Cryptosporidium hominis | Chro.80172 | WD repeat-containing protein 3 |
Cryptosporidium parvum | cgd8_1450 | 11x WD40 repeats containing protein of plant origin |
Dictyostelium discoideum | DDB_G0282623 | U3 small nucleolar ribonucleoprotein |
Drosophila melanogaster | Dmel_CG8064 | CG8064 gene product from transcript CG8064-RA |
Echinococcus granulosus | EgrG_000694000 | WD repeat containing protein 3 |
Entamoeba histolytica | EHI_067830 | WD domain containing protein |
Echinococcus multilocularis | EmuJ_000694000 | WD repeat containing protein 3 |
Giardia lamblia | GL50803_16264 | WD-40 repeat protein |
Homo sapiens | 10885 | WD repeat domain 3 |
Leishmania braziliensis | LbrM.14.0550 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_140580.1 | WD domain, G-beta repeat, putative |
Leishmania infantum | LinJ.14.0580 | hypothetical protein, conserved |
Leishmania major | LmjF.14.0570 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.14.0570 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05321 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15938 | hypothetical protein |
Mus musculus | ENSMUSG00000033285 | WD repeat domain 3 |
Neospora caninum | NCLIV_032360 | WD-40 repeat protein, putative |
Oryza sativa | 4331644 | Os03g0151700 |
Onchocerca volvulus | OVOC11408 |
|
Plasmodium berghei | PBANKA_1311800 | U3 small nucleolar RNA-associated protein 12, putative |
Plasmodium falciparum | PF3D7_1448000 | U3 small nucleolar RNA-associated protein 12, putative |
Plasmodium knowlesi | PKNH_1234100 | U3 small nucleolar RNA-associated protein 12, putative |
Plasmodium vivax | PVX_118095 | WD domain, G-beta repeat domain containing protein |
Plasmodium yoelii | PY01106 | hypothetical protein |
Saccharomyces cerevisiae | YLR129W | Dip2p |
Schistosoma japonicum | Sjp_0311180 | WD repeat-containing protein 3 homolog, putative |
Schistosoma japonicum | Sjp_0012000 | WD repeat-containing protein 3, putative |
Schistosoma japonicum | Sjp_0100790 | WD repeat-containing protein 3, putative |
Schistosoma japonicum | Sjp_0011980 | WD repeat-containing protein 3, putative |
Schistosoma mansoni | Smp_136010 | hypothetical protein |
Schmidtea mediterranea | mk4.000597.05 | |
Schmidtea mediterranea | mk4.000597.06 | |
Trypanosoma brucei gambiense | Tbg972.7.4750 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.4220 | WD domain, G-beta repeat/Dip2/Utp12 Family, putative |
Trypanosoma congolense | TcIL3000_7_3400 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511245.50 | WD domain, G-beta repeat/Dip2/Utp12 Family, putative |
Trypanosoma cruzi | TcCLB.506661.110 | WD domain, G-beta repeat/Dip2/Utp12 Family, putative |
Toxoplasma gondii | TGME49_232380 | WD domain, G-beta repeat-containing protein |
Theileria parva | TP02_0738 | hypothetical protein |
Trichomonas vaginalis | TVAG_342320 | WD repeat containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4220 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4220 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4220 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.4220 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F13H8.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F13H8.2 | Caenorhabditis elegans | sterile | wormbase |
YLR129W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_232380 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.