Detailed view for Smp_163030

Basic information

TDR Targets ID: 282826
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 9.3133 | Length (AA): 528 | MW (Da): 57641 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01798   snoRNA binding domain, fibrillarin
PF09785   Prp31 C terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046540   U4/U6 x U5 tri-snRNP complex  
GO:0000398   nuclear mRNA splicing, via spliceosome  
GO:0000244   assembly of spliceosomal tri-snRNP  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 352 5gip (A) 35 376 25.00 0 1 0.942879 0.22
103 352 2ozb (B) 85 333 67.00 0 1 1.27888 -0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128306)

Species Accession Gene Product
Arabidopsis thaliana AT1G60170   protein EMBRYO DEFECTIVE 1220
Babesia bovis BBOV_II006320   pre-mRNA processing ribonucleoprotein binding region-containing protein
Brugia malayi Bm1_29095   SnoRNA binding domain containing protein
Candida albicans CaO19.82   similar to N terminus of S. cerevisiae U4/U6 snRNP 61kd protein PRP31 (YGR091W)
Candida albicans CaO19.1296   similar to C terminus of S. cerevisiae U4/U6 snRNP 61kd protein PRP31 (YGR091W)
Candida albicans CaO19.8876   similar to C terminus of U4/U6 snRNP 61kd protein
Caenorhabditis elegans CELE_Y110A7A.8   Protein PRP-31
Cryptosporidium hominis Chro.40029   snoRNA binding domain
Cryptosporidium parvum cgd4_150   pre-mRNA splicing protein; Prp31p--like
Dictyostelium discoideum DDB_G0289595   pre-mRNA processing factor 31
Drosophila melanogaster Dmel_CG6876   CG6876 gene product from transcript CG6876-RA
Echinococcus granulosus EgrG_001076000   U4:U6 small nuclear ribonucleoprotein Prp31
Entamoeba histolytica EHI_147490   pre-mRNA splicing factor, putative
Echinococcus multilocularis EmuJ_001076000   U4:U6 small nuclear ribonucleoprotein Prp31
Homo sapiens ENSG00000105618   pre-mRNA processing factor 31
Leishmania braziliensis LbrM.33.0140   trans-splicing factor, putative
Leishmania donovani LdBPK_330140.1   trans-splicing factor, putative
Leishmania infantum LinJ.33.0140   trans-splicing factor, putative
Leishmania major LmjF.33.0130   trans-splicing factor, putative
Leishmania mexicana LmxM.32.0130   trans-splicing factor, putative
Loa Loa (eye worm) LOAG_08730   serologically defined breast cancer antigen NY-BR-99
Mus musculus ENSMUSG00000008373   PRP31 pre-mRNA processing factor 31 homolog (yeast)
Neospora caninum NCLIV_018700   SnoRNA binding domain, related
Oryza sativa 4336619   Os04g0555400
Oryza sativa 4342372   Os07g0141600
Plasmodium berghei PBANKA_1006700   U4/U6 small nuclear ribonucleoprotein PRP31, putative
Plasmodium falciparum PF3D7_0409100   U4/U6 small nuclear ribonucleoprotein PRP31, putative
Plasmodium knowlesi PKNH_0003100   U4/U6 small nuclear ribonucleoprotein PRP31, putative
Plasmodium knowlesi PKNH_0307100   U4/U6 small nuclear ribonucleoprotein PRP31, putative
Plasmodium vivax PVX_000790   U4/U6 small nuclear ribonucleoprotein PRP31, putative
Plasmodium yoelii PY04097   Putative snoRNA binding domain, putative
Saccharomyces cerevisiae YGR091W   Prp31p
Schistosoma japonicum Sjp_0046230   U4/U6 small nuclear ribonucleoprotein Prp31, putative
Schistosoma mansoni Smp_163030   hypothetical protein
Schmidtea mediterranea mk4.014945.00   U4/U6 small nuclear ribonucleoprotein Prp31
Schmidtea mediterranea mk4.035350.00  
Trypanosoma brucei gambiense Tbg972.10.12970   trans-splicing factor, putative
Trypanosoma brucei Tb927.10.10700   splicing factor Prp31
Trypanosoma congolense TcIL3000_10_9000   trans-splicing factor, putative
Trypanosoma cruzi TcCLB.504625.10   trans-splicing factor, putative
Trypanosoma cruzi TcCLB.503583.40   trans-splicing factor, putative
Toxoplasma gondii TGME49_244100   snoRNA binding domain-containing protein
Theileria parva TP02_0595   hypothetical protein, conserved
Trichomonas vaginalis TVAG_224350   prp31, putative

Essentiality

Smp_163030 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.10700 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.10700 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.10700 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.10700 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y110A7A.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y110A7A.8 Caenorhabditis elegans sterile wormbase
YGR091W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1006700 Plasmodium berghei Essential plasmo
TGME49_244100 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_163030 (Schistosoma mansoni), hypothetical protein
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