Detailed view for Smp_155120

Basic information

TDR Targets ID: 282834
Schistosoma mansoni, synaptic ras gtpase activating protein syngap
Source Database / ID:  GeneDB

pI: 8.4885 | Length (AA): 1524 | MW (Da): 171448 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00616   GTPase-activator protein for Ras-like GTPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005096   GTPase activator activity  
GO:0043087   regulation of GTPase activity  
GO:0007165   signal transduction  
GO:0051056   regulation of small GTPase mediated signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
494 849 3bxj (A) 238 674 37.00 0 1 0.528196 0.05
533 893 5cjp (E) 879 1244 18.00 0 1 0.191777 0.48
534 879 1wer (A) 718 1025 25.00 0 1 0.357934 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129873)

Species Accession Gene Product
Caenorhabditis elegans CELE_ZK899.8   Protein GAP-2, isoform A
Caenorhabditis elegans CELE_ZK899.8a   Protein GAP-2, isoform B
Drosophila melanogaster Dmel_CG42684   CG42684 gene product from transcript CG42684-RB
Echinococcus granulosus EgrG_000774500   synaptic ras gtpase activating protein syngap
Echinococcus multilocularis EmuJ_000774500   synaptic ras gtpase activating protein syngap
Homo sapiens ENSG00000136848   DAB2 interacting protein
Homo sapiens 9462   RAS protein activator like 2
Homo sapiens ENSG00000197283   synaptic Ras GTPase activating protein 1
Loa Loa (eye worm) LOAG_03908   hypothetical protein
Loa Loa (eye worm) LOAG_13081   hypothetical protein
Mus musculus ENSMUSG00000026883   disabled 2 interacting protein
Mus musculus ENSMUSG00000067629   synaptic Ras GTPase activating protein 1 homolog (rat)
Mus musculus ENSMUSG00000070565   RAS protein activator like 2
Schistosoma japonicum Sjp_0037470   Ras GTPase-activating protein gap-2, putative
Schistosoma mansoni Smp_155120   synaptic ras gtpase activating protein syngap
Schmidtea mediterranea mk4.006388.00   Ras GTPase-activating protein gap-2
Schmidtea mediterranea mk4.000267.10   Ras GTPase-activating protein gap-2
Schmidtea mediterranea mk4.000800.07   Ras GTPase-activating protein gap-2
Schmidtea mediterranea mk4.026312.00   Ras GTPase-activating protein gap-2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0018 0.5 0.5
0.0125 0.3893 0.9758
0.0121 1 1
0.0071 0.2549 0.2498
0.0058 0.5 0.5
0.0057 0.3491 0.3491
0.0107 0.5 0.5
0.0072 0.2639 0.2639
0.0109 0.4866 0.4866
0.005 0.2612 0.2612

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_155120 (Schistosoma mansoni), synaptic ras gtpase activating protein syngap
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