Detailed view for Smp_010940.3

Basic information

TDR Targets ID: 283705
Schistosoma mansoni, phosphoprotein
Source Database / ID:  GeneDB

pI: 3.7166 | Length (AA): 299 | MW (Da): 32772 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14580   Leucine-rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128510)

Species Accession Gene Product
Arabidopsis thaliana AT3G50690   leucine-rich repeat (LRR) family protein
Babesia bovis BBOV_IV005960   conserved hypothetical protein
Brugia malayi Bm1_26065   Leucine Rich Repeat family protein
Caenorhabditis elegans CELE_T19H12.2   Protein T19H12.2
Caenorhabditis elegans CELE_F33H2.3   Protein F33H2.3
Cryptosporidium hominis Chro.10112   hypothetical protein
Cryptosporidium parvum cgd1_930   U2 snrnp-specific A protein
Dictyostelium discoideum DDB_G0281091   hypothetical protein
Drosophila melanogaster Dmel_CG5784   CG5784 gene product from transcript CG5784-RB
Echinococcus granulosus EgrG_001104800   Acidic leucine rich nuclear phosphoprotein
Echinococcus multilocularis EmuJ_001104800   Acidic leucine rich nuclear phosphoprotein
Homo sapiens ENSG00000143401   acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Homo sapiens ENSG00000140350   acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Homo sapiens ENSG00000136938   acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
Loa Loa (eye worm) LOAG_02507   leucine Rich Repeat family protein
Mus musculus ENSMUSG00000015749   acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Mus musculus ENSMUSG00000032249   acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Mus musculus ENSMUSG00000028333   acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
Neospora caninum NCLIV_035310   inhibitor-1 of protein phosphatase type 2A, putative
Oryza sativa 4333677   Os03g0668900
Plasmodium berghei PBANKA_1016700   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1427900   conserved protein, unknown function
Plasmodium knowlesi PKNH_1330800   hypothetical protein, conserved in Apicomplexan species
Plasmodium vivax PVX_085145   hypothetical protein, conserved
Plasmodium yoelii PY06840   similar to RIKEN cDNA 2810018A15 gene, putative
Schistosoma japonicum Sjp_0042580   Acidic leucine-rich nuclear phosphoprotein 32-related protein, putative
Schistosoma mansoni Smp_010940.3   phosphoprotein
Schistosoma mansoni Smp_010940.4   phosphoprotein
Schistosoma mansoni Smp_010940.1   phosphoprotein
Schmidtea mediterranea mk4.000277.04   Acidic leucine-rich nuclear phosphoprotein 32 family member A
Schmidtea mediterranea mk4.015876.00   Acidic leucine-rich nuclear phosphoprotein 32 family member A
Schmidtea mediterranea mk4.003640.01   Acidic leucine-rich nuclear phosphoprotein 32 family member A
Schmidtea mediterranea mk4.003493.01   Acidic leucine-rich nuclear phosphoprotein 32 family member A
Toxoplasma gondii TGME49_271810   lanp, putative
Theileria parva TP01_0399   hypothetical protein, conserved

Essentiality

Smp_010940.3 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T19H12.2 Caenorhabditis elegans embryonic lethal wormbase
TGME49_271810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_010940.3 (Schistosoma mansoni), phosphoprotein
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