Detailed view for Smp_007730.1

Basic information

TDR Targets ID: 284150
Schistosoma mansoni, ER lumen protein retaining receptor
Source Database / ID:  GeneDB

pI: 9.2382 | Length (AA): 212 | MW (Da): 24528 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00810   ER lumen protein retaining receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0046923   ER retention sequence binding  
GO:0006621   protein retention in ER lumen  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127279)

Species Accession Gene Product
Arabidopsis thaliana AT3G25040   ER retention receptor ERD2b
Arabidopsis thaliana AT1G29330   ER lumen protein retaining receptor
Babesia bovis BBOV_III009160   ER lumen protein retaining receptor
Brugia malayi Bm1_37730   ER lumen protein retaining receptor
Brugia malayi Bm1_52975   ER lumen protein retaining receptor
Candida albicans CaO19.10270   receptor for ER-retention signal
Candida albicans CaO19.2756   receptor for ER-retention signal
Caenorhabditis elegans CELE_C28H8.4   Protein C28H8.4
Caenorhabditis elegans CELE_F09B9.3   Protein ERD-2
Cryptosporidium hominis Chro.80131   endoplasmic reticulum retention receptor
Cryptosporidium parvum cgd8_1110   ER/lumen protein retaining receptor (KDEL receptor), signal peptide plus 4 or more transmembrane domains
Dictyostelium discoideum DDB_G0272124   ER lumen protein retaining receptor
Drosophila melanogaster Dmel_CG5183   KDEL receptor
Echinococcus granulosus EgrG_001117400   ER lumen protein retaining receptor
Echinococcus granulosus EgrG_000131100   ER lumen protein retaining receptor
Entamoeba histolytica EHI_170470   ER lumen protein retaining receptor
Echinococcus multilocularis EmuJ_000131100   ER lumen protein retaining receptor
Echinococcus multilocularis EmuJ_001117400   ER lumen protein retaining receptor
Giardia lamblia GL50803_4502   ER lumen protein retaining receptor
Homo sapiens ENSG00000136240   KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Homo sapiens ENSG00000105438   KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Leishmania braziliensis LbrM.28.0650   ER lumen retaining receptor-like protein
Leishmania donovani LdBPK_280670.1   ER lumen retaining receptor-like protein
Leishmania infantum LinJ.28.0670   ER lumen retaining receptor-like protein
Leishmania major LmjF.28.0630   ER lumen retaining receptor-like protein
Leishmania mexicana LmxM.28.0630   ER lumen retaining receptor-like protein
Loa Loa (eye worm) LOAG_04271   ER lumen protein retaining receptor
Loa Loa (eye worm) LOAG_01978   ER lumen protein retaining receptor
Mus musculus ENSMUSG00000079111   KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Mus musculus ENSMUSG00000002778   KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Neospora caninum NCLIV_068650   endoplasmic reticulum retention receptor, putative
Neospora caninum NCLIV_029080   hypothetical protein
Oryza sativa 4350496   Os11g0473000
Oryza sativa 4339403   Os05g0529300
Oryza sativa 4335613   Os04g0376700
Plasmodium berghei PBANKA_1130200   ER lumen protein retaining receptor, putative
Plasmodium falciparum PF3D7_1353600   ER lumen protein retaining receptor
Plasmodium knowlesi PKNH_1118100   ER lumen protein retaining receptor, putative
Plasmodium vivax PVX_114670   ER lumen protein retaining receptor, putative
Plasmodium yoelii PY05552   er lumen protein retaining receptor-related
Saccharomyces cerevisiae YBL040C   Erd2p
Schistosoma japonicum Sjp_0205660   ER lumen protein retaining receptor, putative
Schistosoma japonicum Sjp_0305510   ER lumen protein retaining receptor 2, putative
Schistosoma mansoni Smp_154160   ER lumen protein retaining receptor
Schistosoma mansoni Smp_007730.3   ER lumen protein retaining receptor
Schistosoma mansoni Smp_007730.2   ER lumen protein retaining receptor
Schistosoma mansoni Smp_007730.1   ER lumen protein retaining receptor
Schmidtea mediterranea mk4.001258.01   ER lumen protein retaining receptor
Schmidtea mediterranea mk4.003522.01   ER lumen protein-retaining receptor 3
Schmidtea mediterranea mk4.001328.00   ER lumen protein-retaining receptor
Trypanosoma brucei gambiense Tbg972.11.9300   ER lumen retaining receptor protein, putative
Trypanosoma brucei Tb927.11.8140   ER lumen retaining receptor protein, putative
Trypanosoma congolense TcIL3000.11.8670   ER lumen retaining receptor protein, putative
Trypanosoma cruzi TcCLB.508815.160   ER lumen retaining receptor protein, putative
Toxoplasma gondii TGME49_256000   endoplasmic reticulum retention receptor
Toxoplasma gondii TGME49_276910   endoplasmic reticulum lumen protein retaining receptor (ERD2) family protein
Theileria parva TP04_0824   ER lumen protein retaining receptor, putative
Trichomonas vaginalis TVAG_242900   er lumen protein retaining receptor, putative
Trichomonas vaginalis TVAG_040450   er lumen protein retaining receptor, putative

Essentiality

Smp_007730.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0410 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.0410 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.0410 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0410 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F09B9.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C28H8.4 Caenorhabditis elegans embryonic lethal wormbase
YBL040C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1130200 Plasmodium berghei Essential plasmo
TGME49_276910 Toxoplasma gondii Probably essential sidik
TGME49_256000 Toxoplasma gondii Probably essential sidik
TGME49_276910 Toxoplasma gondii Probably non-essential sidik
TGME49_256000 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_007730.1 (Schistosoma mansoni), ER lumen protein retaining receptor
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