Detailed view for Smp_132850.1

Basic information

TDR Targets ID: 285646
Schistosoma mansoni, acetyltransferase-related
Source Database / ID:  GeneDB

pI: 8.695 | Length (AA): 427 | MW (Da): 49152 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01553   Acyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016746   transferase activity, transferring acyl groups  
GO:0008415   acyltransferase activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
66 211 5kym (A) 42 188 26.00 0.0088 0.62 0.51192 0.25
320 424 5g4p (A) 10 112 14.00 0 0.08 0.398202 -0.32
324 421 5x9a (A) 13 107 13.00 0.00061 0.09 0.349808 -0.29
329 421 1s1e (A) 45 135 12.00 0.00000016 0.05 0.316099 -0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128553)

Species Accession Gene Product
Arabidopsis thaliana AT2G45670   calcineurin B subunit-related protein
Drosophila melanogaster Dmel_CG32699   CG32699 gene product from transcript CG32699-RB
Echinococcus granulosus EgrG_000607800   acetyltransferase
Echinococcus multilocularis EmuJ_000607800   acetyltransferase
Giardia lamblia GL50803_15987   Hypothetical protein
Homo sapiens ENSG00000087253   lysophosphatidylcholine acyltransferase 2
Homo sapiens ENSG00000153395   lysophosphatidylcholine acyltransferase 1
Leishmania braziliensis LbrM.29.2380   hypothetical protein, conserved
Leishmania donovani LdBPK_292520.1   acyltransferase, putative
Leishmania infantum LinJ.29.2520   hypothetical protein, conserved
Leishmania major LmjF.29.2410   hypothetical protein, conserved
Leishmania mexicana LmxM.08_29.2410   hypothetical protein, conserved
Mus musculus ENSMUSG00000033192   lysophosphatidylcholine acyltransferase 2
Mus musculus ENSMUSG00000021608   lysophosphatidylcholine acyltransferase 1
Mus musculus ENSMUSG00000033794   lysophosphatidylcholine acyltransferase 2B
Oryza sativa 4342043   Os06g0712300
Schistosoma japonicum Sjp_0311620   ko:K00680 LPCAT1, lysophosphatidylcholine acyltransferase 1 [EC:2.3.1.-], putative
Schistosoma japonicum Sjp_0044650   Lysophosphatidylcholine acyltransferase 2-B, putative
Schistosoma mansoni Smp_132850.2   acetyltransferase-related
Schistosoma mansoni Smp_132850.1   acetyltransferase-related
Schmidtea mediterranea mk4.036568.00   1-acylglycerophosphocholine O-acyltransferase 1
Schmidtea mediterranea mk4.018457.00   1-acylglycerophosphocholine O-acyltransferase 1
Schmidtea mediterranea mk4.010284.00   1-acylglycerophosphocholine O-acyltransferase 1
Schmidtea mediterranea mk4.019659.00   1-acylglycerophosphocholine O-acyltransferase 1
Trypanosoma brucei gambiense Tbg972.10.4820   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.3.3520   acyltransferase, putative
Trypanosoma brucei Tb927.3.3360   acyltransferase, putative
Trypanosoma brucei Tb927.10.3880   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_3220   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_42470   acyltransferase, putative
Trypanosoma cruzi TcCLB.508153.230   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506957.130   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510323.80   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511001.80   hypothetical protein, conserved
Trichomonas vaginalis TVAG_375220   conserved hypothetical protein
Trichomonas vaginalis TVAG_060530   conserved hypothetical protein
Trichomonas vaginalis TVAG_271700   conserved hypothetical protein
Trichomonas vaginalis TVAG_454210   1-acylglycerophosphocholine O-acyltransferase, putative
Trichomonas vaginalis TVAG_120530   1-acyl-sn-glycerol-3-phosphate acyltransferase eta, putative
Trichomonas vaginalis TVAG_221660   conserved hypothetical protein
Trichomonas vaginalis TVAG_282750   conserved hypothetical protein

Essentiality

Smp_132850.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.3360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.3360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.3360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.3360 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.3880 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.3880 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.3880 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.3880 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0006 0.5 0.5
0.0006 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_132850.1 (Schistosoma mansoni), acetyltransferase-related
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