Detailed view for PF3D7_1455600

Basic information

TDR Targets ID: 2860
Plasmodium falciparum, ferlin, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.0724 | Length (AA): 1904 | MW (Da): 224721 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 130 2fk9 (A) 9 136 14.00 0.0000000000016 0.6 0.07 -0.35
3 134 1gmi (A) 5 135 15.00 0 0.79 0.12 -0.33
1441 1569 1tjx (A) 270 405 19.00 0 0.45 0.06 -0.25
4 129 4ihb (A) 0 122 20.00 0.81 0.95 0.287176 0.1
5 105 3n5a (A) 282 384 30.00 0.27 0.36 0.173046 0.92
664 845 4u5a (A) 48 240 22.00 0.15 0.05 0.236588 -0.2
1149 1267 3ik2 (A) 378 495 34.00 0.59 0.09 0.0914 1.15
1685 1784 1rh8 (A) 4654 4757 23.00 0.99 0.21 0.165521 0.14
2 111 2d8k (A) 24 134 20.00 0.032 0.41 0.0981615 1.05
3 50 4rj9 (A) 6 53 29.00 0.11 0.08 0.0847177 2.03
171 303 2uzp (A) 157 292 13.00 0.33 0.43 0.103297 -0.19
1165 1274 3ik2 (A) 388 495 32.00 0.69 0.01 0.103061 0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_141266)

Species Accession Gene Product
Babesia bovis BBOV_II003690   hypothetical protein
Cryptosporidium hominis Chro.20248   heat shock protein DNAJ pfj4
Cryptosporidium parvum cgd2_2320   conserved hypothetical protein
Neospora caninum NCLIV_026570   hypothetical protein
Plasmodium berghei PBANKA_1319300   ferlin, putative
Plasmodium falciparum PF3D7_1455600   ferlin, putative
Plasmodium knowlesi PKNH_1226200   ferlin, putative
Plasmodium vivax PVX_117685   ferlin, putative
Plasmodium yoelii PY05745   similar to Plasmodium berghei heat shock related protein, encoded by GenBank Accession Number L04508, and Trypanosoma cruzi heat
Theileria parva TP04_0212   hypothetical protein
Theileria parva TP04_0211   ferlin, putative

Essentiality

PF3D7_1455600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1319300 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0071 0.2549 0
0.0018 0.5 0.5
0.0125 0.3893 1
0.0107 0.5 0.5
0.0109 0.4866 0.5
0.0058 0.5 0.5
0.005 0.2612 0
0.0072 0.2639 0
0.0057 0.3491 0.5
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1455600 (Plasmodium falciparum), ferlin, putative
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