Detailed view for Smp_176270

Basic information

TDR Targets ID: 286134
Schistosoma mansoni, syntaxin
Source Database / ID:  GeneDB

pI: 8.0138 | Length (AA): 403 | MW (Da): 45098 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05739   SNARE domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0016192   vesicle-mediated transport  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
117 355 4jeh (B) 31 245 16.00 0 0.76 0.636152 -0.44
166 355 4jeh (B) 38 245 25.00 0.058 0.46 0.705064 -0.56
303 363 3b5n (B) 191 251 30.00 0 0.01 0.358465 0.27
312 348 5buz (C) 189 225 38.00 0.97 0.05 0.399411 0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127926)

Species Accession Gene Product
Arabidopsis thaliana AT3G24350   syntaxin-32
Babesia bovis BBOV_III006380   conserved hypothetical protein
Brugia malayi Bm1_28080   Syntaxin F55A11.2
Candida albicans CaO19.13460   similar to syntaxin required in ER to Golgi transport
Candida albicans CaO19.6039   similar to syntaxin required in ER to Golgi transport
Caenorhabditis elegans CELE_F55A11.2   Protein SYX-5
Cryptosporidium hominis Chro.10317   syntaxin 5
Cryptosporidium parvum cgd1_2830   syntaxin 5A ortholog, possible transmembrane domain or GPI at C-terminus
Dictyostelium discoideum DDB_G0277565   t-SNARE family protein
Drosophila melanogaster Dmel_CG4214   Syntaxin 5
Echinococcus granulosus EgrG_000057500   syntaxin 5
Echinococcus granulosus EgrG_000086800   syntaxin 5
Entamoeba histolytica EHI_181290   syntaxin, putative
Entamoeba histolytica EHI_080870   syntaxin, putative
Echinococcus multilocularis EmuJ_000057500   syntaxin 5
Echinococcus multilocularis EmuJ_000086800   syntaxin 5
Homo sapiens ENSG00000162236   syntaxin 5
Leishmania braziliensis LbrM.32.0120   Qa-SNARE protein
Leishmania donovani LdBPK_320070.1   Qa-SNARE protein
Leishmania infantum LinJ.32.0070   Qa-SNARE protein
Leishmania major LmjF.32.0070   Qa-SNARE protein
Leishmania mexicana LmxM.31.0070   syntaxin 5, putative
Loa Loa (eye worm) LOAG_09126   hypothetical protein
Loa Loa (eye worm) LOAG_10241   hypothetical protein
Mus musculus ENSMUSG00000010110   syntaxin 5A
Neospora caninum NCLIV_046380   syntaxin, putative
Plasmodium berghei PBANKA_1346800   Qa-SNARE protein, putative
Plasmodium falciparum PF3D7_1332000   syntaxin, Qa-SNARE family
Plasmodium knowlesi PKNH_1268600   syntaxin 5, putative
Plasmodium vivax PVX_082530   syntaxin 5, putative
Plasmodium yoelii PY07410   syntaxin 5
Plasmodium yoelii PY07007   syntaxin 5
Saccharomyces cerevisiae YLR026C   Sed5p
Schistosoma japonicum Sjp_0043560   ko:K08490 syntaxin 5, putative
Schistosoma mansoni Smp_176270   syntaxin
Schmidtea mediterranea mk4.033554.00   Putative syntaxin-5
Schmidtea mediterranea mk4.001564.04   Putative syntaxin-5
Schmidtea mediterranea mk4.000182.06   Putative syntaxin
Trypanosoma brucei gambiense Tbg972.10.16590   syntaxin 5, putative
Trypanosoma brucei Tb927.10.14200   syntaxin 5
Trypanosoma cruzi TcCLB.511283.40   syntaxin 5, putative
Trypanosoma cruzi TcCLB.506525.40   syntaxin 5, putative
Toxoplasma gondii TGME49_226600   syntaxin 5, putative
Theileria parva TP02_0324   syntaxin 5, putative
Trichomonas vaginalis TVAG_318380   syntaxin, putative
Trichomonas vaginalis TVAG_182300   syntaxin-5, putative

Essentiality

Smp_176270 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14200 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.14200 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14200 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14200 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F55A11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F55A11.2 Caenorhabditis elegans larval arrest wormbase
CELE_F55A11.2 Caenorhabditis elegans larval lethal wormbase
CELE_F55A11.2 Caenorhabditis elegans slow growth wormbase
CELE_F55A11.2 Caenorhabditis elegans sterile wormbase
YLR026C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1346800 Plasmodium berghei Essential plasmo
TGME49_226600 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_176270 (Schistosoma mansoni), syntaxin
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