Detailed view for Smp_046100

Basic information

TDR Targets ID: 287619
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 10.3965 | Length (AA): 125 | MW (Da): 14280 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07225   NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008137   NADH dehydrogenase (ubiquinone) activity  
GO:0005739   mitochondrion  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133634)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG12859   CG12859 gene product from transcript CG12859-RA
Echinococcus granulosus EgrG_000687800   NADH dehydrogenase ubiquinone 1 beta
Echinococcus multilocularis EmuJ_000687800   NADH dehydrogenase (ubiquinone) 1 beta
Homo sapiens ENSG00000065518   NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
Mus musculus 68194   NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
Mus musculus 100042503   predicted gene 3873
Schistosoma japonicum Sjp_0206330   IPR009866,NADH-ubiquinone oxidoreductase, subunit NDUFB4,domain-containing
Schistosoma japonicum Sjp_0317980   expressed protein
Schistosoma mansoni Smp_046100   hypothetical protein
Schmidtea mediterranea mk4.001473.02  
Schmidtea mediterranea mk4.003711.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0647 0.3929 0.3897
0.0611 0.3911 0.3895
0.0624 0.3908 0.3883
0.0292 0.3724 0.3688
0.0346 0.3724 0.3688
0.0292 0.3724 0.3688
0.0295 0.2912 0.3125
0.0581 0.4742 0.7718
0.0278 0.2898 0.2951
0.0299 0.2961 0.2976
0.0598 0.3869 0.3869
0.058 0.4499 0.7542
0.0288 0.3068 0.3708
0.0632 0.3876 0.3876
0.0618 0.3881 0.3881
0.0289 0.3701 0.3688
0.0598 0.367 0.3871
0.0289 0.3701 0.3688
0.0619 0.4488 0.751
0.0298 0.3724 0.3688
0.0598 0.367 0.3871
0.0588 0.3678 0.3661
0.0587 0.4523 0.7559
0.061 0.3799 0.3799
0.0593 0.4537 0.757
0.0346 0.4342 0.7422
0.0298 0.3724 0.3688
0.0581 0.4742 0.7718
0.0286 0.2838 0.2928
0.0585 0.4508 0.6058
0.0278 0.2867 0.3806
0.028 0.3088 0.3659
0.0594 0.453 0.7565
0.0606 0.4498 0.751
0.0577 0.4486 0.751
0.0585 0.3551 0.375
0.0299 0.3111 0.7496
0.028 0.3789 0.3779

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_046100 (Schistosoma mansoni), hypothetical protein
Title for this comment
Comment