Detailed information for compound 265326

Basic information

Technical information
  • TDR Targets ID: 265326
  • Name: 8-chloro-3-cyclohexylimino-N,5-diphenylphenaz in-2-amine
  • MW: 479.015 | Formula: C30H27ClN4
  • H donors: 1 H acceptors: 0 LogP: 7.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)nc1c(n2c2ccccc2)c/c(=N\C2CCCCC2)/c(c1)Nc1ccccc1
  • InChi: 1S/C30H27ClN4/c31-21-16-17-29-27(18-21)34-28-19-25(32-22-10-4-1-5-11-22)26(33-23-12-6-2-7-13-23)20-30(28)35(29)24-14-8-3-9-15-24/h1,3-5,8-11,14-20,23,32H,2,6-7,12-13H2/b33-26+
  • InChiKey: KPLQKLZCORLFAQ-MHTZHOPKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-chloro-3-cyclohexylimino-N,5-diphenyl-phenazin-2-amine
  • 8-chloro-3-cyclohexylimino-N,5-diphenyl-2-phenazinamine
  • (8-chloro-3-cyclohexylimino-5-phenyl-phenazin-2-yl)-phenyl-amine
  • B1912

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi NADH-ubiquinone oxidoreductase 19 kDa subunit 0.0096 0.0706 0.1663
Schistosoma mansoni hypothetical protein 0.015 0.1542 0.1524
Echinococcus multilocularis NADH:ubiquinone oxidoreductase 0.0191 0.2176 0.216
Loa Loa (eye worm) acyl carrier protein 0.0052 0.0033 0.0078
Schistosoma mansoni hypothetical protein 0.0151 0.1556 0.1539
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) iron sulfur 0.0055 0.0074 0.0054
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 2 0.0071 0.0315 0.0295
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0191 0.2176 0.216
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0101 0.0788 0.0892
Brugia malayi NADH-ubiquinone oxidoreductase 18 kDa subunit, mitochondrial precursor 0.0155 0.1617 0.381
Brugia malayi NADH-ubiquinone oxidoreductase subunit B14.5b 0.0135 0.1305 0.3074
Schistosoma mansoni hypothetical protein 0.0109 0.0917 0.0898
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0252 0.2903
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0211 0.0497
Leishmania major hypothetical protein, conserved 0.0088 0.0578 0.7219
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0101 0.0788 0.188
Leishmania major hypothetical protein, conserved 0.0078 0.0426 0.5208
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0319 1
Schistosoma mansoni NADH-plastoquinone oxidoreductase 0.0055 0.0074 0.0054
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0252 0.0595
Echinococcus granulosus NADH ubiquinone oxidoreductase subunit 10 0.0135 0.1305 0.1287
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Loa Loa (eye worm) NADH Ubiquinone oxidoreductase Fe-S protein family member 0.0151 0.1556 0.3666
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit B 0.0055 0.0074 0.0103
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 23 kDa subunit 0.0082 0.0494 0.1165
Loa Loa (eye worm) NADH:ubiquinone oxidoreductase 17.2 kDa subunit family protein 0.0214 0.2532 0.5965
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0821 0.0802
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0821 0.0802
Schistosoma mansoni hypothetical protein 0.0096 0.0706 0.0687
Schistosoma mansoni lipoxygenase 0.0058 0.0127 0.0106
Schistosoma mansoni hypothetical protein 0.025 0.31 0.3085
Wolbachia endosymbiont of Brugia malayi monovalent cation/H+ antiporter subunit C 0.01 0.0766 0.1825
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0082 0.0494 0.0475
Loa Loa (eye worm) NADH dehydrogenase subunit 5 0.0093 0.0667 0.1572
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0222 0.2653 0.2637
Brugia malayi hypothetical protein 0.0058 0.0127 0.0298
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0126 0.117 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0319 0.0625
Brugia malayi hypothetical protein 0.0324 0.4245 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0127 0.0106
Schistosoma mansoni hypothetical protein 0.0324 0.4245 0.4233
Loa Loa (eye worm) hypothetical protein 0.0121 0.1095 0.2579
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0088 0.0578 0.1357
Echinococcus granulosus expressed conserved protein 0.0338 0.445 0.4439
Brugia malayi NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial 0.0071 0.0315 0.0742
Loa Loa (eye worm) deoxynucleoside kinase 0.0222 0.2653 0.6249
Schistosoma mansoni hypothetical protein 0.0179 0.1992 0.1975
Echinococcus granulosus acyl carrier protein mitochondrial 0.0052 0.0033 0.0012
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 beta 0.0289 0.3701 0.3688
Loa Loa (eye worm) hypothetical protein 0.0074 0.0368 0.0868
Brugia malayi Melibiase family protein 0.0069 0.0288 0.0679
Schistosoma mansoni hypothetical protein 0.0078 0.0426 0.0406
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0319 1
Schistosoma mansoni hypothetical protein 0.0289 0.3701 0.3688
Echinococcus multilocularis RUN 0.0058 0.0127 0.0106
Loa Loa (eye worm) hypothetical protein 0.0071 0.0315 0.0742
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) 0.0105 0.0843 0.1036
Echinococcus multilocularis microtubule associated protein 2 0.0696 1 1
Mycobacterium ulcerans NADH dehydrogenase subunit N 0.0105 0.0843 0.0956
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0101 0.0788 1
Leishmania major hypothetical protein, conserved 0.0069 0.029 0.3402
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0288 0.0268
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) 0.0121 0.1095 0.1359
Loa Loa (eye worm) hypothetical protein 0.0126 0.117 0.2757
Mycobacterium ulcerans NADH dehydrogenase subunit I 0.0082 0.0494 0.0545
Loa Loa (eye worm) hypothetical protein 0.0058 0.0127 0.0298
Schistosoma mansoni hypothetical protein 0.0179 0.1992 0.1975
Echinococcus multilocularis expressed protein 0.0088 0.0578 0.0559
Echinococcus multilocularis expressed conserved protein 0.0078 0.0426 0.0406
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) 0.0126 0.117 0.1456
Brugia malayi NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial precursor 0.0071 0.0315 0.0742
Echinococcus granulosus Complex 1 LYR protein 0.0179 0.1992 0.1975
Loa Loa (eye worm) hypothetical protein 0.0167 0.1808 0.4258
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0071 0.0315 0.3734
Echinococcus granulosus NADH dehydrogenase subunit 4 0.0128 0.1201 0.1182
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0821 0.0802
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0288 0.0268
Echinococcus multilocularis NADH ubiquinone oxidoreductase, subunit 10 0.0135 0.1305 0.1287
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase subunit B 0.0135 0.1305 0.3074
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 18 kDa subunit 0.0155 0.1617 0.381
Echinococcus granulosus Pfam-B_14860 domain containing protein 0.0135 0.1305 0.1287
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0074 0.0368 0.0348
Onchocerca volvulus 0.0167 0.1808 0.4174
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0211 0.019
Echinococcus granulosus NADH dehydrogenase ubiquinone Fe S protein 1 0.0094 0.0671 0.0651
Schistosoma mansoni hypothetical protein 0.0058 0.0127 0.0106
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0252 0.0232
Loa Loa (eye worm) hypothetical protein 0.0233 0.2831 0.6669
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0821 0.0802
Echinococcus granulosus RUN 0.0058 0.0127 0.0106
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0101 0.0788 0.0769
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0127 1
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0082 0.0494 0.0475
Schistosoma mansoni hypothetical protein 0.0167 0.1808 0.1791
Brugia malayi Probable NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrialprecursor 0.0071 0.0315 0.0742
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.015 0.1542 0.1931
Loa Loa (eye worm) hypothetical protein 0.0121 0.1095 0.2579
Trichomonas vaginalis NADH dehydrogenase 24 kDa subunit, putative 0.0071 0.0315 0.054
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0101 0.0788 0.0769
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase Fe-S protein 7 0.0055 0.0074 0.0175
Brugia malayi RH49308p 0.0171 0.1868 0.44
Onchocerca volvulus 0.0192 0.2192 0.5092
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain A 0.0147 0.1505 0.3665
Loa Loa (eye worm) hypothetical protein 0.0088 0.0578 0.1362
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0101 0.0788 1
Brugia malayi NADH-ubiquinone oxidoreductase B12 subunit 0.025 0.31 0.7301
Brugia malayi RNA binding protein 0.0064 0.0211 0.0497
Brugia malayi NADH:ubiquinone oxidoreductase 17.2 kD subunit family protein 0.0214 0.2532 0.5965
Schistosoma mansoni hypothetical protein 0.0135 0.1305 0.1287
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase Fe-S subunit 0.0055 0.0072 0.0096
Echinococcus multilocularis NADH dehydrogenase 0.0116 0.102 0.1001
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 beta 0.015 0.1546 0.1528
Echinococcus multilocularis thymidine kinase 0.0071 0.0319 0.0299
Mycobacterium ulcerans NADH dehydrogenase subunit B 0.0055 0.0074 0.0049
Loa Loa (eye worm) NADH dehydrogenase 1 beta subcomplex subunit 7 0.015 0.1546 0.3641
Schistosoma mansoni thymidine kinase 0.0071 0.0319 0.0299
Brugia malayi hypothetical protein 0.0093 0.0667 0.1572
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0222 0.2653 0.2637
Trypanosoma brucei Protein of unknown function (DUF498/DUF598), putative 0.0088 0.0578 0.7219
Schistosoma mansoni hypothetical protein 0.0116 0.102 0.1001
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) 0.0082 0.0497 0.0594
Brugia malayi ETC complex I subunit conserved region family protein 0.0155 0.1617 0.381
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0426 0.5208
Brugia malayi hypothetical protein 0.0121 0.1095 0.2579
Loa Loa (eye worm) hypothetical protein 0.0171 0.1868 0.44
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 19 kDa subunit 0.0096 0.0706 0.1663
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0821 0.0802
Trypanosoma cruzi NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 0.0055 0.0074 0.0546
Brugia malayi NADH-ubiquinone oxidoreductase 30 kDa subunit, mitochondrial precursor 0.0126 0.117 0.2757
Echinococcus multilocularis expressed conserved protein 0.0338 0.445 0.4439
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0319 1
Mycobacterium ulcerans NADH dehydrogenase subunit E 0.0071 0.0315 0.0333
Schistosoma mansoni hypothetical protein 0.0109 0.0917 0.0898
Echinococcus granulosus expressed conserved protein 0.0135 0.1305 0.1287
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K) 0.01 0.0766 0.0939
Echinococcus granulosus NADH dehydrogenase 0.0116 0.102 0.1001
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0252 0.2903
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0821 1
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain M 0.0128 0.1201 0.2907
Mycobacterium ulcerans NADH dehydrogenase subunit A 0.0147 0.1505 0.1739
Schistosoma mansoni hypothetical protein 0.0233 0.2831 0.2816
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0052 0.0033 0.0012
Echinococcus multilocularis expressed conserved protein 0.0135 0.1305 0.1287
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0319 0.0625
Schistosoma mansoni rab6-interacting 0.0058 0.0127 0.0106
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0101 0.0788 1
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 alpha 0.0233 0.2831 0.2816
Echinococcus granulosus NADH dehydrogenase (ubiquinone) 1 alpha 0.0096 0.0706 0.0687
Echinococcus granulosus NADH dehydrogenase ubiquinone iron sulfur 0.0126 0.117 0.1152
Schistosoma mansoni hypothetical protein 0.0338 0.445 0.4439
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0101 0.0788 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0211 0.019
Echinococcus granulosus geminin 0.0338 0.4461 0.445
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 beta 0.015 0.1546 0.1528
Echinococcus granulosus tar DNA binding protein 0.0064 0.0211 0.019
Echinococcus granulosus NADH dehydrogenase 0.025 0.31 0.3085
Brugia malayi Probable NADH-ubiquinone oxidoreductase B18 subunit, putative 0.015 0.1546 0.3641
Schistosoma mansoni polycystin 1-related 0.0058 0.0127 0.0106
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0236 0.2872 0.2857
Brugia malayi hypothetical protein 0.0135 0.1305 0.3074
Brugia malayi NADH-ubiquinone oxidoreductase subunit B17.2 0.0191 0.2176 0.5126
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0319 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0127 0.0106
Schistosoma mansoni loxhd1 0.0058 0.0127 0.0106
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0101 0.0788 1
Brugia malayi NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor 0.0094 0.0671 0.158
Echinococcus multilocularis geminin 0.0338 0.4461 0.445
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0211 0.019
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0052 0.0033 0.0078
Brugia malayi NADH dehydrogenase I, A subunit 0.0147 0.1505 0.3546
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) 0.0096 0.0706 0.0861
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0101 0.0788 0.0967
Brugia malayi hypothetical protein 0.0088 0.0578 0.1362
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain K 0.01 0.0766 0.1825
Loa Loa (eye worm) hypothetical protein 0.0192 0.2192 0.5163
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0252 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0211 0.019
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 2 0.0071 0.0315 0.0295
Echinococcus granulosus NADH dehydrogenase ubiquinone iron sulfur 0.0055 0.0074 0.0054
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0071 0.0315 0.3734
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0557 0.7844 1
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0222 0.2653 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.2872 0.6765
Echinococcus granulosus NADH dehydrogenase ubiquinone iron sulfur 0.0155 0.1617 0.16
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0599 0.8498 1
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 beta 0.0289 0.3701 0.3688
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 beta 0.0236 0.2872 0.2857
Brugia malayi Deoxynucleoside kinase family protein 0.0222 0.2653 0.6249
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0127 0.0106
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0821 0.0802
Onchocerca volvulus 0.0236 0.2872 0.6718
Schistosoma mansoni hypothetical protein 0.0088 0.0578 0.0559
Echinococcus granulosus NADH dehydrogenase ubiquinone Fe S protein 2 0.0071 0.0315 0.0295
Onchocerca volvulus 0.0058 0.0127 0.0156
Schistosoma mansoni hypothetical protein 0.0372 0.498 0.4969
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Schistosoma mansoni microtubule-associated protein tau 0.0696 1 1
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0071 0.0315 0.0295
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0599 0.8498 1
Echinococcus granulosus NADH:ubiquinone oxidoreductase 0.0191 0.2176 0.216
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0821 0.0802
Schistosoma mansoni hypothetical protein 0.0338 0.4461 0.445
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0252 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0211 0.019
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) iron sulfur 0.0126 0.117 0.1152
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) Fe S protein 2 0.0071 0.0315 0.0295
Schistosoma mansoni hormone-regulated proliferation-associated 20 kDa protein short form 0.0372 0.498 0.4969
Schistosoma mansoni hypothetical protein 0.015 0.1546 0.1528
Loa Loa (eye worm) NADH dehydrogenase subunit 3 0.0052 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0071 0.0315 0.0742
Mycobacterium ulcerans NADH dehydrogenase subunit D 0.0071 0.0315 0.0333
Onchocerca volvulus 0.0093 0.0667 0.1449
Treponema pallidum acyl carrier protein 0.0052 0.0033 0.5
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit G 0.0094 0.0671 0.1588
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 0.0071 0.0315 0.3734
Onchocerca volvulus 0.0058 0.0127 0.0156
Echinococcus multilocularis expressed conserved protein 0.0135 0.1305 0.1287
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0101 0.0788 1
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain C 0.0126 0.117 0.2831
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0252 0.2903
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit I 0.0082 0.0494 0.1148
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0211 0.019
Brugia malayi hypothetical protein 0.0058 0.0127 0.0298
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0288 0.0679
Echinococcus granulosus thymidine kinase 0.0071 0.0319 0.0299
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0164 0.1756 0.1739
Echinococcus granulosus NADH dehydrogenase ubiquinone 1 beta 0.0151 0.1555 0.1537
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain N 0.0105 0.0843 0.2016
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0101 0.0788 0.1857
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 24 kDa subunit 0.0071 0.0315 0.0742
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0127 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0319 0.0625
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase B12 subunit 0.025 0.31 0.7301
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0222 0.2653 0.2637
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0101 0.0788 1
Mycobacterium tuberculosis Possible formate hydrogenase HycE (FHL) 0.0081 0.0472 0.0561
Loa Loa (eye worm) hypothetical protein 0.0324 0.4245 1
Brugia malayi NADH-ubiquinone oxidoreductase 15 kDa subunit 0.0109 0.0917 0.2161
Echinococcus multilocularis Complex 1 LYR protein 0.0179 0.1992 0.1975
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 alpha 0.0233 0.2831 0.2816
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase B22 subunit 0.0179 0.1992 0.4692
Brugia malayi TAR-binding protein 0.0064 0.0211 0.0497
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain J 0.0121 0.1095 0.2643
Echinococcus granulosus NADH dehydrogenase ubiquinone iron sulfur 0.0082 0.0494 0.0475
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase chain L 0.0312 0.405 1
Schistosoma mansoni hypothetical protein 0.0233 0.2831 0.2816
Trypanosoma cruzi Complex 1 protein (LYR family), putative 0.0069 0.029 0.3402
Schistosoma mansoni hypothetical protein 0.0192 0.2192 0.2176
Echinococcus multilocularis thymidine kinase 0.0071 0.0319 0.0299
Onchocerca volvulus 0.0121 0.1095 0.247
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0127 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0252 0.0595
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit D 0.0071 0.0315 0.0702
Echinococcus multilocularis Aminotransferase class V pyridoxal phosphate binding site 0.0372 0.498 0.4969
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase subunit 0.0191 0.2176 0.5335
Schistosoma mansoni hypothetical protein 0.0179 0.1992 0.1975
Brugia malayi GH05862p 0.0192 0.2192 0.5163
Mycobacterium ulcerans NADH dehydrogenase subunit M 0.0128 0.1201 0.138
Entamoeba histolytica hypothetical protein 0.0071 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0426 0.1005
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0236 0.2872 0.2857
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0071 0.0315 0.0295
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.015 0.1542 0.3755
Trypanosoma brucei NADH-ubiquinone oxidoreductase B14 subunit 0.0069 0.029 0.3402
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0101 0.0788 0.0769
Brugia malayi NADH-ubiquinone oxidoreductase ASHI subunit, mitochondrial precursor 0.0236 0.2872 0.6765
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0127 0.0298
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0426 0.5208
Onchocerca volvulus NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 homolog 0.015 0.1546 0.3547
Trypanosoma brucei NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 0.0055 0.0074 0.0546
Echinococcus multilocularis hypothetical protein 0.0096 0.0706 0.0687
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0127 0.0106
Brugia malayi hypothetical protein 0.0233 0.2831 0.6669
Echinococcus granulosus NADH dehydrogenase iron sulfur protein 6 0.0151 0.1556 0.1539
Echinococcus granulosus thymidine kinase 0.0071 0.0319 0.0299
Onchocerca volvulus NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 homolog 0.0096 0.0706 0.1541
Loa Loa (eye worm) hypothetical protein 0.0121 0.1095 0.2579
Onchocerca volvulus NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 homolog 0.0178 0.1974 0.4572
Mycobacterium ulcerans NADH dehydrogenase subunit C 0.0126 0.117 0.1344
Schistosoma mansoni rab6-interacting 0.0058 0.0127 0.0106
Brugia malayi NADH-ubiquinone oxidoreductase B8 subunit 0.0116 0.102 0.2403
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0094 0.0671 0.0651
Trypanosoma cruzi Complex 1 protein (LYR family), putative 0.0069 0.029 0.3402
Schistosoma mansoni hypothetical protein 0.0338 0.4461 0.445
Onchocerca volvulus Putative NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial 0.0121 0.1095 0.247
Echinococcus granulosus expressed conserved protein 0.0078 0.0426 0.0406
Onchocerca volvulus 0.0214 0.2532 0.5906
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0101 0.0788 0.1857
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0426 0.5208
Onchocerca volvulus NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 homolog 0.0324 0.4245 1
Trypanosoma cruzi Protein of unknown function (DUF498/DUF598), putative 0.0088 0.0578 0.7219
Brugia malayi NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial precursor 0.0082 0.0494 0.1165
Echinococcus granulosus Aminotransferase class V pyridoxal phosphate binding site 0.0372 0.498 0.4969
Brugia malayi NADH-ubiquinone oxidoreductase B22 subunit 0.0178 0.1974 0.465
Brugia malayi Probable complex I intermediate-associated protein 30, mitochondrialprecursor. 0.0202 0.2354 0.5545
Brugia malayi Doublecortin family protein 0.0058 0.0127 0.0298
Echinococcus multilocularis transfer RNA-Ile 0.0071 0.0319 0.0299
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0071 0.0315 0.3734
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 beta 0.0236 0.2872 0.2857
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0071 0.0319 0.0299
Brugia malayi hypothetical protein 0.0121 0.1095 0.2579
Mycobacterium ulcerans NADH dehydrogenase subunit L 0.0148 0.1516 0.1751
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0252 0.2903
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0319 0.0625
Trypanosoma cruzi NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial precursor 0.0055 0.0074 0.0546
Onchocerca volvulus 0.0233 0.2831 0.662
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0164 0.1756 0.1739
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.015 0.1542 0.1782
Loa Loa (eye worm) RNA binding protein 0.0064 0.0211 0.0497
Brugia malayi Probable NADH-ubiquinone oxidoreductase 13 kDa-A subunit,mitochondrial precursor 0.0151 0.1556 0.3666
Onchocerca volvulus NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 homolog 0.0116 0.102 0.2292
Brugia malayi Probable NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrialprecursor 0.0055 0.0074 0.0175
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0211 0.0497
Echinococcus granulosus NADH dehydrogenase subunit 1 0.015 0.1542 0.1524
Leishmania major NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial precursor 0.0055 0.0074 0.0546
Loa Loa (eye worm) hypothetical protein 0.0135 0.1305 0.3074
Chlamydia trachomatis acyl carrier protein 0.0052 0.0033 0.5
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) Fe S protein 1 0.0094 0.0671 0.0651
Brugia malayi NADH dehydrogenase subunit 3 0.0052 0.0021 0.0049
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) iron sulfur 0.0082 0.0494 0.0475
Loa Loa (eye worm) complex I intermediate-associated protein 30 0.0202 0.2354 0.5545
Wolbachia endosymbiont of Brugia malayi NADH:ubiquinone oxidoreductase 18 kDa subunit 0.0155 0.1617 0.3944
Schistosoma mansoni lipoxygenase 0.0164 0.1756 0.1739
Echinococcus multilocularis NADH dehydrogenase 0.025 0.31 0.3085
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 15 kDa subunit 0.0109 0.0917 0.2161
Mycobacterium ulcerans NADH dehydrogenase subunit J 0.0121 0.1095 0.1254
Schistosoma mansoni hypothetical protein 0.0155 0.1617 0.16
Schistosoma mansoni acyl carrier protein 0.0052 0.0033 0.0012
Echinococcus multilocularis NADH dehydrogenase iron sulfur protein 6 0.0151 0.1556 0.1539
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) 0.0071 0.0315 0.0361
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 30 kDa subunit 0.0126 0.117 0.2757
Trypanosoma cruzi Protein of unknown function (DUF498/DUF598), putative 0.0088 0.0578 0.7219
Leishmania major hypothetical protein, conserved 0.0055 0.0072 0.0509
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0127 0.0106
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) iron sulfur 0.0155 0.1617 0.16
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I) 0.006 0.0155 0.0156
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) 1 beta 0.0151 0.1555 0.1537
Onchocerca volvulus Putative NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 0.0071 0.0315 0.0607
Onchocerca volvulus 0.0151 0.1555 0.3569
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit E 0.0071 0.0315 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0319 0.0625
Mycobacterium ulcerans NADH dehydrogenase subunit K 0.01 0.0766 0.0866
Loa Loa (eye worm) hypothetical protein 0.0058 0.0127 0.0298
Brugia malayi NADH-ubiquinone oxidoreductase AGGG subunit homolog, mitochondrialprecursor 0.0121 0.1095 0.2579
Echinococcus granulosus expressed protein 0.0088 0.0578 0.0559
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase B8 subunit 0.0116 0.102 0.2403
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0211 0.0497
Brugia malayi GRIM-19 protein 0.0167 0.1808 0.4258

Activities

Activity type Activity value Assay description Source Reference
Concentration (functional) = 0.6 ug ml-1 100% inhibition of growth of rifampicin resistant Mycobacterium smegmatis 607 strain in vitro ChEMBL. 3279207
Concentration (functional) = 3 ug ml-1 Concentration for 100% inhibition of growth of dapsone sensitive Mycobacterium smegmatis 607 strain in vitro ChEMBL. 3279207
Concentration (functional) = 20 ug ml-1 100% inhibition of growth of clofazimine resistant Mycobacterium smegmatis 607 strain in vitro ChEMBL. 3279207

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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