Detailed view for Smp_118850

Basic information

TDR Targets ID: 287706
Schistosoma mansoni, rho gtpase activating protein
Source Database / ID:  GeneDB

pI: 8.4548 | Length (AA): 400 | MW (Da): 44993 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00620   RhoGAP domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 90 2mqa (A) 17 95 11.00 0 0.01 0.4314 -1.52
103 249 5a51 (A) 32 189 20.00 0 0.82 0.5119 0.3
106 248 4rj9 (A) 7 159 20.00 0 0.68 0.5079 0
312 392 1xa6 (A) 289 350 40.00 0.38 0.13 0.2239 0.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133498)

Species Accession Gene Product
Brugia malayi Bm1_10165   Synapse defective protein 1
Brugia malayi Bm1_27485   Synapse defective protein 1
Caenorhabditis elegans CELE_F35D2.5   Protein SYD-1, isoform C
Dictyostelium discoideum DDB_G0291840   C2 calcium/lipid-binding region-containing protein
Drosophila melanogaster Dmel_CG1976   Rho GTPase activating protein at 100F
Echinococcus granulosus EgrG_000441500   rho GTPase activating protein
Echinococcus multilocularis EmuJ_000441500   rho GTPase activating protein
Homo sapiens ENSG00000105137   synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Loa Loa (eye worm) LOAG_13623   hypothetical protein
Loa Loa (eye worm) LOAG_15887   hypothetical protein
Loa Loa (eye worm) LOAG_12716   hypothetical protein
Loa Loa (eye worm) LOAG_14059   synapse defective protein 1
Loa Loa (eye worm) LOAG_12714   hypothetical protein
Mus musculus ENSMUSG00000032714   synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Schistosoma japonicum Sjp_0099190   Rho GTPase-activating protein 100F, putative
Schistosoma mansoni Smp_118850   rho gtpase activating protein
Schmidtea mediterranea mk4.011452.00   Rho GTPase-activating protein syd-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0109 0.4866 0.4866
0.0072 0.2639 0.2639
0.005 0.2612 0.2612
0.0125 0.3893 0.9758
0.0018 0.5 0.5
0.0107 0.5 0.5
0.0057 0.3491 0.3491
0.0058 0.5 0.5
0.0071 0.2549 0.2498
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_118850 (Schistosoma mansoni), rho gtpase activating protein
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