Detailed view for Smp_062250.2

Basic information

TDR Targets ID: 324206
Schistosoma mansoni, myosin light chain
Source Database / ID:  GeneDB

pI: 4.1504 | Length (AA): 146 | MW (Da): 16584 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13405   EF-hand domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 146 4djc (A) 1 148 39.00 0.000000000083 1 1.5466 -0.81
1 146 5w1a (B) 1 149 35.00 0 1 1.4484 -0.67
4 146 3ox6 (A) 19 166 32.00 0.00000000021 1 1.46975 -1.23
4 76 5z1q (A) 21 95 29.00 0 1 1.0564 -2.28
83 146 5i0i (I) 83 146 51.00 0 0.92 0.857756 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130101)

Species Accession Gene Product
Brugia malayi Bm1_21060   myosin
Caenorhabditis elegans CELE_T12D8.6   Protein MLC-5
Drosophila melanogaster Dmel_CG3201   Myosin light chain cytoplasmic
Echinococcus granulosus EgrG_000612300   myosin essential light chain striated adductor
Echinococcus multilocularis EmuJ_000573900   myosin 2 essential light chain
Echinococcus multilocularis EmuJ_000612300   myosin essential light chain striated adductor
Homo sapiens ENSG00000092841   myosin, light chain 6, alkali, smooth muscle and non-muscle
Homo sapiens ENSG00000168530   myosin, light chain 1, alkali
Homo sapiens ENSG00000196465   myosin, light chain 6B, alkali, smooth muscle and non-muscle
Loa Loa (eye worm) LOAG_08242   myosin
Mus musculus 102635661   myosin light polypeptide 6-like
Mus musculus ENSMUSG00000039824   myosin, light polypeptide 6B
Mus musculus 102643184   myosin light polypeptide 6-like
Mus musculus ENSMUSG00000090841   myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Mus musculus ENSMUSG00000061816   myosin, light polypeptide 1
Schistosoma japonicum Sjp_0059810   IPR002048,Calcium-binding EF-hand,domain-containing
Schistosoma japonicum Sjp_0120030   Myosin-2 essential light chain, putative
Schistosoma mansoni Smp_062250.2   myosin light chain
Schmidtea mediterranea mk4.000857.04   Myosin-2 essential light chain

Essentiality

Smp_062250.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T12D8.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.2966 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_062250.2 (Schistosoma mansoni), myosin light chain
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